STRINGSTRING
STAT3 STAT3 IRF4 IRF4 IL15 IL15 STAT6 STAT6 GLI3 GLI3 ZAP70 ZAP70 CD74 CD74 SRF SRF CD3G CD3G BRAF BRAF ENSOCUP00000033540 ENSOCUP00000033540 IL6R IL6R THEMIS THEMIS BCL2 BCL2 ITPKB ITPKB CD3D CD3D ENSOCUP00000042001 ENSOCUP00000042001 ATG5 ATG5 SLAMF6 SLAMF6 TOX TOX CD4 CD4 CD28 CD28 G1U0P1_RABIT G1U0P1_RABIT BATF BATF G1TP12_RABIT G1TP12_RABIT CCR7 CCR7 IL6 IL6 GATA3 GATA3 SYK SYK SHH SHH MTOR MTOR TBX21 TBX21 PTPRC PTPRC CARD11 CARD11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STAT3Signal transducer and activator of transcription. (770 aa)
IRF4Interferon regulatory factor 4. (451 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
GLI3GLI family zinc finger 3. (1575 aa)
ZAP70Tyrosine-protein kinase. (623 aa)
CD74CD74 molecule. (375 aa)
SRFSerum response factor. (685 aa)
CD3GIGc2 domain-containing protein. (182 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (767 aa)
ENSOCUP00000033540Ig-like domain-containing protein. (203 aa)
IL6RInterleukin 6 receptor. (569 aa)
THEMISThymocyte selection associated. (634 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (924 aa)
CD3DIg_4 domain-containing protein. (177 aa)
ENSOCUP00000042001Ig-like domain-containing protein. (185 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (245 aa)
SLAMF6Ig-like domain-containing protein. (387 aa)
TOXThymocyte selection associated high mobility group box. (564 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
G1U0P1_RABITUncharacterized protein. (209 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
G1TP12_RABITUncharacterized protein. (166 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
GATA3GATA binding protein 3. (444 aa)
SYKTyrosine-protein kinase. (630 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
TBX21T-box transcription factor 21. (520 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
CARD11Caspase recruitment domain family member 11. (1044 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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