13 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	G1SCF2_RABIT	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (175 aa)
	NEDD8	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity). (81 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (537 aa)
	DCUN1D5	DCN1-like protein. (237 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)
	DCUN1D4	DCN1-like protein. (285 aa)
	DCUN1D1	DCN1-like protein. (345 aa)
	TRIM40	Tripartite motif containing 40. (229 aa)
	UBE2M	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (457 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	UBE2F	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (220 aa)
	ENSOCUP00000034885	Uncharacterized protein. (128 aa)
	DCUN1D2	DCN1-like protein. (250 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCUN1D1	DCUN1D3	ENSOCUP00000010659	ENSOCUP00000016804	DCN1-like protein.	DCN1-like protein.	0.554
DCUN1D1	DCUN1D4	ENSOCUP00000010659	ENSOCUP00000010634	DCN1-like protein.	DCN1-like protein.	0.532
DCUN1D1	DCUN1D5	ENSOCUP00000010659	ENSOCUP00000005629	DCN1-like protein.	DCN1-like protein.	0.487
DCUN1D1	ENSOCUP00000034885	ENSOCUP00000010659	ENSOCUP00000034885	DCN1-like protein.	Uncharacterized protein.	0.741
DCUN1D1	G1SCF2_RABIT	ENSOCUP00000010659	ENSOCUP00000000017	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.741
DCUN1D1	NAE1	ENSOCUP00000010659	ENSOCUP00000000498	DCN1-like protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.678
DCUN1D1	NEDD8	ENSOCUP00000010659	ENSOCUP00000002526	DCN1-like protein.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.886
DCUN1D1	UBA3	ENSOCUP00000010659	ENSOCUP00000007065	DCN1-like protein.	Ubiquitin like modifier activating enzyme 3.	0.793
DCUN1D1	UBE2F	ENSOCUP00000010659	ENSOCUP00000033984	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.788
DCUN1D1	UBE2M	ENSOCUP00000010659	ENSOCUP00000014290	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.967
DCUN1D2	DCUN1D3	ENSOCUP00000046591	ENSOCUP00000016804	DCN1-like protein.	DCN1-like protein.	0.588
DCUN1D2	DCUN1D4	ENSOCUP00000046591	ENSOCUP00000010634	DCN1-like protein.	DCN1-like protein.	0.538
DCUN1D2	DCUN1D5	ENSOCUP00000046591	ENSOCUP00000005629	DCN1-like protein.	DCN1-like protein.	0.551
DCUN1D2	ENSOCUP00000034885	ENSOCUP00000046591	ENSOCUP00000034885	DCN1-like protein.	Uncharacterized protein.	0.726
DCUN1D2	G1SCF2_RABIT	ENSOCUP00000046591	ENSOCUP00000000017	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.726
DCUN1D2	NAE1	ENSOCUP00000046591	ENSOCUP00000000498	DCN1-like protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.644
DCUN1D2	NEDD8	ENSOCUP00000046591	ENSOCUP00000002526	DCN1-like protein.	NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).	0.925
DCUN1D2	UBA3	ENSOCUP00000046591	ENSOCUP00000007065	DCN1-like protein.	Ubiquitin like modifier activating enzyme 3.	0.869
DCUN1D2	UBE2F	ENSOCUP00000046591	ENSOCUP00000033984	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.899
DCUN1D2	UBE2M	ENSOCUP00000046591	ENSOCUP00000014290	DCN1-like protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.826