STRINGSTRING
B2M B2M ROR2 ROR2 LTF LTF G1TGC0_RABIT G1TGC0_RABIT ACVR2A ACVR2A CDC73 CDC73 IL12B IL12B KLF10 KLF10 TFE3 TFE3 NFKBIA NFKBIA NEDD9 NEDD9 HOXA7 HOXA7 C1QC C1QC APCS APCS IL20 IL20 GPR68 GPR68 TNFAIP6 TNFAIP6 PITHD1 PITHD1 NCKAP1L NCKAP1L ANKRD54 ANKRD54 CALCA CALCA MITF MITF G1SGM6_RABIT G1SGM6_RABIT ACIN1 ACIN1 INHBA INHBA CD101 CD101 TCTA TCTA CTR9 CTR9 FAXDC2 FAXDC2 UBASH3B UBASH3B MTOR MTOR POU4F2 POU4F2 HCLS1 HCLS1 PRXL2A PRXL2A RIPK1 RIPK1 FSHR FSHR TNFRSF11B TNFRSF11B STAT3 STAT3 EIF6 EIF6 RNF41 RNF41 TMEM178A TMEM178A CSF3 CSF3 CUL4A CUL4A NF1 NF1 G1SV95_RABIT G1SV95_RABIT FBXW7 FBXW7 ABCB10 ABCB10 IL23A IL23A FOXP1 FOXP1 G1SSE7_RABIT G1SSE7_RABIT THPO THPO POU4F1 POU4F1 TNF TNF L3MBTL1 L3MBTL1 HSPA9 HSPA9 HMGB3 HMGB3 GPR171 GPR171 CREB1 CREB1 PIK3R1 PIK3R1 STAT5B STAT5B GAS2L1 GAS2L1 DCSTAMP DCSTAMP IL17A IL17A PLA2G3 PLA2G3 FBN1 FBN1 CD74 CD74 LIF LIF CCR1 CCR1 BRD1 BRD1 ZFP36 ZFP36 LYN LYN JAG1 JAG1 INPP5D INPP5D ITPKB ITPKB GABPA GABPA GPR137B GPR137B ENSOCUP00000037329 ENSOCUP00000037329 MEIS2 MEIS2 CDK6 CDK6 STAT1 STAT1 PTPN2 PTPN2 RB1 RB1 HIF1A HIF1A LEO1 LEO1 LOC100348748 LOC100348748 DLL1 DLL1 ENSOCUP00000041840 ENSOCUP00000041840 RARG RARG TESC TESC RCOR1 RCOR1 MPL MPL LOX LOX ENSOCUP00000044284 ENSOCUP00000044284 PPARGC1B PPARGC1B PPP3CA PPP3CA HAX1 HAX1 ENSOCUP00000045925 ENSOCUP00000045925 SMAP1 SMAP1 MEF2C MEF2C MEIS1 MEIS1 LEF1 LEF1 NOTCH2 NOTCH2 FES FES KITLG KITLG SCIN SCIN CTNNB1 CTNNB1 ENSOCUP00000032761 ENSOCUP00000032761 PAF1 PAF1 HSF1 HSF1 CSF3R CSF3R LRRC17 LRRC17 LOC103345451 LOC103345451 CLDN18 CLDN18 ENSOCUP00000029917 ENSOCUP00000029917 ENSOCUP00000029775 ENSOCUP00000029775 RAB7B RAB7B ISG15 ISG15 KAT7 KAT7 ZBTB16 ZBTB16 NMNAT3 NMNAT3 WDR61 WDR61 NDFIP1 NDFIP1 TRAF6 TRAF6 CSF1 CSF1 IL34 IL34 GATA1 GATA1 TRIB1 TRIB1 G1U7S6_RABIT G1U7S6_RABIT PRKCA PRKCA ETS1 ETS1 PTX4 PTX4 STAT5A STAT5A PRMT1 PRMT1 HOXA5 HOXA5 MAFB MAFB EVI2B EVI2B G1TXH1_RABIT G1TXH1_RABIT FOS FOS MED1 MED1 ADIPOQ ADIPOQ CTNNBIP1 CTNNBIP1 CASP10 CASP10 HOXA9 HOXA9 CNOT4 CNOT4 PTK2B PTK2B LDB1 LDB1 G1TLG4_RABIT G1TLG4_RABIT RASSF2 RASSF2 PIAS3 PIAS3 RARA RARA CEBPB CEBPB CIB1 CIB1 FSHB FSHB HOXB8 HOXB8 NINJ1 NINJ1 LOC100346323 LOC100346323 ACVR1B ACVR1B FAM210B FAM210B P4HTM P4HTM TAL1 TAL1 TNFSF11 TNFSF11 OCSTAMP OCSTAMP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
G1TGC0_RABITUncharacterized protein. (214 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
CDC73Cell division cycle 73. (728 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
KLF10Kruppel like factor 10. (529 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (569 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (828 aa)
HOXA7Homeobox domain-containing protein. (234 aa)
C1QCComplement C1q C chain. (308 aa)
APCSPentaxin. (223 aa)
IL20Interleukin 20. (187 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. (276 aa)
PITHD1PITH domain containing 1. (288 aa)
NCKAP1LNCK associated protein 1 like. (1181 aa)
ANKRD54ANK_REP_REGION domain-containing protein. (180 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
G1SGM6_RABITUncharacterized protein. (186 aa)
ACIN1Apoptotic chromatin condensation inducer 1. (1336 aa)
INHBAInhibin subunit beta A. (424 aa)
CD101CD101 molecule. (1023 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
FAXDC2Fatty acid hydroxylase domain containing 2; Belongs to the sterol desaturase family. (309 aa)
UBASH3BUbiquitin associated and SH3 domain containing B. (649 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2547 aa)
POU4F2POU domain protein. (392 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (487 aa)
PRXL2APeroxiredoxin like 2A. (229 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (670 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (703 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
RNF41Ring finger protein 41. (317 aa)
TMEM178ATransmembrane protein 178A. (297 aa)
CSF3Colony stimulating factor 3. (204 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
NF1Neurofibromin 1. (2841 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FBXW7F-box and WD repeat domain containing 7. (780 aa)
ABCB10ATP binding cassette subfamily B member 10. (661 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
FOXP1Fork-head domain-containing protein. (714 aa)
G1SSE7_RABITUncharacterized protein; Belongs to the peptidase C14A family. (306 aa)
THPOThrombopoietin. (348 aa)
POU4F1POU domain protein. (339 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
L3MBTL1Uncharacterized protein. (496 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
HMGB3Uncharacterized protein. (270 aa)
GPR171G protein-coupled receptor 171; Belongs to the G-protein coupled receptor 1 family. (319 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
GAS2L1GAR domain-containing protein. (221 aa)
DCSTAMPDC_STAMP domain-containing protein. (283 aa)
IL17AInterleukin 17A. (153 aa)
PLA2G3Phospholipase A2 group III. (636 aa)
FBN1Fibrillin 1. (2831 aa)
CD74CD74 molecule. (375 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
CCR1Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
BRD1Bromodomain containing 1. (1090 aa)
ZFP36ZFP36 ring finger protein. (338 aa)
LYNTyrosine-protein kinase. (636 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (910 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (924 aa)
GABPAGA binding protein transcription factor subunit alpha. (560 aa)
GPR137BG protein-coupled receptor 137B. (393 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
MEIS2Meis homeobox 2. (477 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
RB1RB transcriptional corepressor 1. (943 aa)
HIF1AUncharacterized protein. (851 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (701 aa)
LOC100348748IGv domain-containing protein. (604 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RARGUncharacterized protein. (415 aa)
TESCTescalcin. (240 aa)
RCOR1REST corepressor 1. (386 aa)
MPLMPL proto-oncogene, thrombopoietin receptor. (635 aa)
LOXLysyl oxidase. (419 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
PPARGC1BPPARG coactivator 1 beta. (1125 aa)
PPP3CASerine/threonine-protein phosphatase. (695 aa)
HAX1Uncharacterized protein. (426 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
SMAP1Small ArfGAP 1. (489 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MEIS1Meis homeobox 1. (465 aa)
LEF1Lymphoid enhancer binding factor 1. (414 aa)
NOTCH2Notch receptor 2. (2481 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (857 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
SCINScinderin. (759 aa)
CTNNB1Catenin beta 1. (741 aa)
ENSOCUP00000032761Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (183 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (780 aa)
HSF1Heat shock transcription factor 1. (680 aa)
CSF3RColony stimulating factor 3 receptor. (1027 aa)
LRRC17Leucine rich repeat containing 17. (469 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
ENSOCUP00000029775DUF1279 domain-containing protein. (199 aa)
RAB7BUncharacterized protein. (280 aa)
ISG15ISG15 ubiquitin like modifier. (164 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (614 aa)
ZBTB16Zinc finger and BTB domain containing 16. (762 aa)
NMNAT3CTP_transf_like domain-containing protein. (363 aa)
WDR61WD repeat domain 61. (230 aa)
NDFIP1Nedd4 family interacting protein 1. (226 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (552 aa)
CSF1Colony stimulating factor 1. (535 aa)
IL34Interleukin 34. (200 aa)
GATA1GATA binding protein 1. (413 aa)
TRIB1Tribbles pseudokinase 1. (206 aa)
G1U7S6_RABITUncharacterized protein. (209 aa)
PRKCAProtein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (664 aa)
ETS1Uncharacterized protein. (533 aa)
PTX4Pentraxin 4. (432 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
HOXA5Homeobox A5. (381 aa)
MAFBMAF bZIP transcription factor B. (307 aa)
EVI2BEcotropic viral integration site 2B. (455 aa)
G1TXH1_RABITBTB domain-containing protein. (421 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
ADIPOQC1q domain-containing protein. (244 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
CASP10Caspase-10; Belongs to the peptidase C14A family. (469 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (276 aa)
CNOT4CCR4-NOT transcription complex subunit 4. (713 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
LDB1LIM domain binding 1. (410 aa)
G1TLG4_RABITUncharacterized protein. (197 aa)
RASSF2Ras association domain family member 2. (325 aa)
PIAS3Protein inhibitor of activated STAT 3. (520 aa)
RARARetinoic acid receptor alpha. (462 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
CIB1Uncharacterized protein. (143 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
HOXB8Homeobox B8. (151 aa)
NINJ1Ninjurin 1. (152 aa)
LOC100346323Uncharacterized protein. (240 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
FAM210BDUF1279 domain-containing protein. (195 aa)
P4HTMProlyl 4-hydroxylase, transmembrane. (484 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (319 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (481 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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