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BMP6 BMP6 BMPR1A BMPR1A ACVR2A ACVR2A ADRB2 ADRB2 BMP2 BMP2 TGFB3 TGFB3 BMP4 BMP4 G1T067_RABIT G1T067_RABIT WNT10B WNT10B P2RX7 P2RX7 TENT5A TENT5A G1SV95_RABIT G1SV95_RABIT OSR1 OSR1 NIPBL NIPBL ALOX5 ALOX5 TGFB2 TGFB2 PTPN11 PTPN11 SMAD3 SMAD3 ACTN3 ACTN3 TMEM119 TMEM119 BMP7 BMP7 ATRAID ATRAID WNT4 WNT4 KL KL OSR2 OSR2 SCUBE2 SCUBE2 LTF LTF SOX11 SOX11 ADGRV1 ADGRV1 CCN1 CCN1 PKDCC PKDCC ACVR1 ACVR1 TACR1 TACR1 ANO6 ANO6 WNT5A WNT5A ZBTB16 ZBTB16 PTN PTN ISG15 ISG15 LOC103345451 LOC103345451 SLC8A1 SLC8A1 BMPR2 BMPR2 ENSOCUP00000037329 ENSOCUP00000037329 TFAP2A TFAP2A ENSOCUP00000041840 ENSOCUP00000041840 BMPR1B BMPR1B ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 MEF2C MEF2C ATP2B1 ATP2B1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP6Bone morphogenetic protein 6. (411 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
ADRB2Adrenoceptor beta 2. (437 aa)
BMP2Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
G1T067_RABITFam20C domain-containing protein. (543 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
TENT5ATerminal nucleotidyltransferase 5A. (446 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
NIPBLNipped-B protein. (2580 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
SMAD3SMAD family member 3. (230 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (900 aa)
TMEM119Transmembrane protein 119. (337 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (229 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
KLKlotho. (1005 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1024 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
SOX11Transcription factor SOX. (446 aa)
ADGRV1Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6298 aa)
CCN1Cellular communication network factor 1. (386 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (372 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
ANO6Anoctamin. (1003 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
ZBTB16Zinc finger and BTB domain containing 16. (762 aa)
PTNPleiotrophin. (242 aa)
ISG15ISG15 ubiquitin like modifier. (164 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
TFAP2ATranscription factor AP-2 alpha. (732 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ATP2B1Plasma membrane calcium-transporting ATPase 1; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis. Plays a role in blood pressure regulation through regulation of intracellular calcium concentration and nitric oxide production leading to regulation of vascular smooth muscle cells vasoconstriction. Positively regulates bone mineralization through absorption of calcium from the intestine. Plays dual roles in osteoclast differentiation and survival by regulating RANKL-ind [...] (1249 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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