STRINGSTRING
PSMD10 PSMD10 PBK PBK FBXO5 FBXO5 WNT5A WNT5A CDCA5 CDCA5 STRA8 STRA8 PDGFRB PDGFRB PPP1R10 PPP1R10 NRM NRM RAD51C RAD51C PKD2 PKD2 KIF20B KIF20B RAD21 RAD21 ANAPC5 ANAPC5 SLF2 SLF2 CDK1 CDK1 STOX1 STOX1 LRP6 LRP6 NUSAP1 NUSAP1 FEN1 FEN1 GPSM2 GPSM2 SLC6A4 SLC6A4 MEPCE MEPCE TTL TTL NKX3-1 NKX3-1 SLF1 SLF1 E2F8 E2F8 PTPN11 PTPN11 RPS6KB1 RPS6KB1 CDC6 CDC6 E2F7 E2F7 PLK4 PLK4 STAT5B STAT5B USP19 USP19 TGFB2 TGFB2 MAD2L1BP MAD2L1BP CEP120 CEP120 HYAL1 HYAL1 SMC2 SMC2 LGMN LGMN RRM2 RRM2 NR2E1 NR2E1 DDX11 DDX11 PIWIL2 PIWIL2 SRPK2 SRPK2 NCAPG NCAPG INCENP INCENP BCL2L11 BCL2L11 CCNT1 CCNT1 DYRK3 DYRK3 ATRX ATRX CCNK CCNK USP2 USP2 SASS6 SASS6 RHNO1 RHNO1 MAD2L1 MAD2L1 CDC23 CDC23 CDC25C CDC25C CDC16 CDC16 G1SV95_RABIT G1SV95_RABIT FGF10 FGF10 IL1A IL1A KMT2E KMT2E WNT10B WNT10B PCID2 PCID2 CUL4A CUL4A ADAM17 ADAM17 EGFR EGFR APP APP TAS1R2 TAS1R2 INO80 INO80 SVIL SVIL PLRG1 PLRG1 AURKC AURKC DDR2 DDR2 THOC1 THOC1 SMPD3 SMPD3 DRD2 DRD2 LSM11 LSM11 YTHDC2 YTHDC2 TPR TPR MEIOC MEIOC CDK4 CDK4 NSFL1C NSFL1C PKD1 PKD1 TMOD3 TMOD3 G1T4I8_RABIT G1T4I8_RABIT PLCG2 PLCG2 SMC5 SMC5 RRM1 RRM1 EDN1 EDN1 PKP4 PKP4 STIL STIL CDC25B CDC25B PRKCE PRKCE SPAG5 SPAG5 CDKN1B CDKN1B MNAT1 MNAT1 ANAPC7 ANAPC7 TBX3 TBX3 IGF1R IGF1R MAPRE3 MAPRE3 G1T8C0_RABIT G1T8C0_RABIT MAP3K20 MAP3K20 CCND2 CCND2 RACGAP1 RACGAP1 PSRC1 PSRC1 CSPP1 CSPP1 CKS1B CKS1B EREG EREG CDC73 CDC73 CIT CIT ADAMTS1 ADAMTS1 EGF EGF PHIP PHIP KIF14 KIF14 GIPC2 GIPC2 G1TCH5_RABIT G1TCH5_RABIT BRCA2 BRCA2 TAL1 TAL1 EIF4EBP1 EIF4EBP1 MAPK15 MAPK15 CHEK2 CHEK2 CDT1 CDT1 SOX15 SOX15 LOC103347509 LOC103347509 RANBP1 RANBP1 RARA RARA PRDM7 PRDM7 ANXA1 ANXA1 RAD51C-2 RAD51C-2 PPP1R35 PPP1R35 TRIM32 TRIM32 G1TLX8_RABIT G1TLX8_RABIT CXCR5 CXCR5 GEN1 GEN1 ANAPC11 ANAPC11 G1TRH9_RABIT G1TRH9_RABIT CCNY CCNY ZBED6 ZBED6 LOC100343361 LOC100343361 G1TTM1_RABIT G1TTM1_RABIT WNT4 WNT4 INS INS CDC27 CDC27 MED1 MED1 KIF3B KIF3B ATAD5 ATAD5 GLI1 GLI1 IGF1 IGF1 AIF1 AIF1 IL1B IL1B G1TXW1_RABIT G1TXW1_RABIT PAGR1 PAGR1 HES1 HES1 ROCK2 ROCK2 TBX2 TBX2 NPM2 NPM2 MAP10 MAP10 CDC7 CDC7 CENPV CENPV G1U1H6_RABIT G1U1H6_RABIT PHB2 PHB2 ECT2 ECT2 G1U373_RABIT G1U373_RABIT STAT5A STAT5A CD28 CD28 OOEP OOEP NUMA1 NUMA1 XRCC3 XRCC3 DDX39B DDX39B PRKCA PRKCA DRD3 DRD3 OVOL1 OVOL1 CDC42-2 CDC42-2 ANKRD17 ANKRD17 NCAPG2 NCAPG2 DBF4B DBF4B POLDIP2 POLDIP2 CRNN CRNN PRAP1 PRAP1 LOC100338666 LOC100338666 MACROH2A1 MACROH2A1 RAB11B RAB11B ENSOCUP00000027928 ENSOCUP00000027928 PDGFB PDGFB ENSOCUP00000028034 ENSOCUP00000028034 WIZ WIZ SHB SHB SPHK1 SPHK1 UBXN2B UBXN2B ENSOCUP00000030830 ENSOCUP00000030830 EPGN EPGN CUL3 CUL3 MAD1L1 MAD1L1 STXBP4 STXBP4 THOC5 THOC5 LOC103345451 LOC103345451 HSF1 HSF1 PAF1 PAF1 RAD51B RAD51B SPDYC SPDYC NCAPH2 NCAPH2 ENSOCUP00000033208 ENSOCUP00000033208 CCNT2 CCNT2 ENSOCUP00000033989 ENSOCUP00000033989 SIN3A SIN3A SMOC2 SMOC2 FGFR2 FGFR2 BIRC5 BIRC5 NDC80 NDC80 ENSOCUP00000035983 ENSOCUP00000035983 PLCB1 PLCB1 CEP295 CEP295 ENSOCUP00000037105 ENSOCUP00000037105 ENSOCUP00000037329 ENSOCUP00000037329 RDX RDX ENSOCUP00000037977 ENSOCUP00000037977 RRM2B RRM2B KAT5 KAT5 RUNDC3B RUNDC3B CCND3 CCND3 CDC14B CDC14B ENSOCUP00000038717 ENSOCUP00000038717 BTC BTC ENSOCUP00000039146 ENSOCUP00000039146 NCAPH NCAPH CKS2 CKS2 DTL DTL CPSF3 CPSF3 SIRT2 SIRT2 ENSOCUP00000039970 ENSOCUP00000039970 FOSL1 FOSL1 CUL4B CUL4B SMC4 SMC4 NSMCE2 NSMCE2 RB1 RB1 DYNC1LI1 DYNC1LI1 PROX1 PROX1 MTBP MTBP EZH2 EZH2 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000042026 ENSOCUP00000042026 CDC14A CDC14A INSR INSR ZBED6CL ZBED6CL ENSOCUP00000043082 ENSOCUP00000043082 TGM1 TGM1 KIF23 KIF23 RCC2 RCC2 ENSOCUP00000044284 ENSOCUP00000044284 HNRNPU HNRNPU FAM178B FAM178B ENSOCUP00000045925 ENSOCUP00000045925 ENSOCUP00000047247 ENSOCUP00000047247 ENSOCUP00000047323 ENSOCUP00000047323 CDC25A CDC25A CDC42 CDC42 ENSOCUP00000047968 ENSOCUP00000047968 CITED2 CITED2 FBXO42 FBXO42 ENSOCUP00000048431 ENSOCUP00000048431 LFNG LFNG MECP2 MECP2 HOXA13 HOXA13 ENSOCUP00000049162 ENSOCUP00000049162 KLHL18 KLHL18 C12H6orf89 C12H6orf89 PKN2 PKN2 ENSOCUP00000049983 ENSOCUP00000049983
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMD10ANK_REP_REGION domain-containing protein. (226 aa)
PBKPDZ binding kinase. (322 aa)
FBXO5F-box protein 5. (444 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
CDCA5Cell division cycle associated 5. (301 aa)
STRA8Stimulated by retinoic acid 8. (366 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
PPP1R10Protein phosphatase 1 regulatory subunit 10. (820 aa)
NRMNurim. (307 aa)
RAD51CRECA_2 domain-containing protein. (371 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (994 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1758 aa)
RAD21RAD21 cohesin complex component. (630 aa)
ANAPC5Anaphase promoting complex subunit 5. (755 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1167 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
STOX1Storkhead box 1. (977 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
NUSAP1Uncharacterized protein. (431 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
GPSM2Uncharacterized protein. (684 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (777 aa)
MEPCEMethylphosphate capping enzyme. (668 aa)
TTLTubulin tyrosine ligase. (377 aa)
NKX3-1NK3 homeobox 1. (159 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1015 aa)
E2F8E2F transcription factor 8. (867 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] (490 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
E2F7E2F transcription factor 7. (959 aa)
PLK4Polo like kinase 4. (969 aa)
STAT5BSignal transducer and activator of transcription. (786 aa)
USP19Ubiquitin specific peptidase 19. (1379 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAD2L1BPMAD2L1 binding protein. (274 aa)
CEP120Centrosomal protein 120. (979 aa)
HYAL1Hyaluronidase. (497 aa)
SMC2Structural maintenance of chromosomes 2. (1126 aa)
LGMNLegumain. (435 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (367 aa)
NR2E1Uncharacterized protein. (475 aa)
DDX11Helicase ATP-binding domain-containing protein. (330 aa)
PIWIL2Piwi like RNA-mediated gene silencing 2; Belongs to the argonaute family. (971 aa)
SRPK2SRSF protein kinase 2. (739 aa)
NCAPGNon-SMC condensin I complex subunit G. (1014 aa)
INCENPInner centromere protein. (904 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (194 aa)
CCNT1Cyclin T1; Belongs to the cyclin family. (1010 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
ATRXATRX chromatin remodeler. (2472 aa)
CCNKCyclin K; Belongs to the cyclin family. (559 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (607 aa)
SASS6SAS-6 centriolar assembly protein. (657 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa)
MAD2L1Mitotic arrest deficient 2 like 1. (205 aa)
CDC23Cell division cycle 23. (597 aa)
CDC25CCell division cycle 25C. (483 aa)
CDC16Cell division cycle 16. (560 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
KMT2ELysine methyltransferase 2E. (1475 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PCID2PCI domain containing 2. (486 aa)
CUL4ACullin 4A; Belongs to the cullin family. (759 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
TAS1R2Taste 1 receptor member 2. (836 aa)
INO80INO80 complex ATPase subunit. (1559 aa)
SVILSupervillin. (2121 aa)
PLRG1Pleiotropic regulator 1. (515 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (292 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (848 aa)
THOC1THO complex 1. (657 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (657 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
LSM11LSM11, U7 small nuclear RNA associated. (235 aa)
YTHDC2YTH domain containing 2. (1367 aa)
TPRTranslocated promoter region, nuclear basket protein. (2362 aa)
MEIOCMeiosis specific with coiled-coil domain. (1035 aa)
CDK4Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (392 aa)
NSFL1CNSFL1 cofactor. (373 aa)
PKD1Uncharacterized protein. (2465 aa)
TMOD3Uncharacterized protein. (352 aa)
G1T4I8_RABITUncharacterized protein. (1307 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
SMC5SMC_N domain-containing protein. (1144 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (745 aa)
EDN1Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. (202 aa)
PKP4Plakophilin 4. (1191 aa)
STILSTIL centriolar assembly protein. (1207 aa)
CDC25BCell division cycle 25B. (413 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
SPAG5Sperm associated antigen 5. (1177 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
ANAPC7Anaphase promoting complex subunit 7. (597 aa)
TBX3Uncharacterized protein. (242 aa)
IGF1RTyrosine-protein kinase receptor. (1464 aa)
MAPRE3Microtubule associated protein RP/EB family member 3. (281 aa)
G1T8C0_RABITUncharacterized protein. (311 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase 20. (875 aa)
CCND2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa)
RACGAP1Rac GTPase activating protein 1. (634 aa)
PSRC1Proline and serine rich coiled-coil 1. (363 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1216 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
EREGEpiregulin. (169 aa)
CDC73Cell division cycle 73. (728 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2070 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (887 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
PHIPPleckstrin homology domain interacting protein. (1742 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1633 aa)
GIPC2GIPC PDZ domain containing family member 2. (259 aa)
G1TCH5_RABITMOEP19 domain-containing protein. (146 aa)
BRCA2BRCA2 DNA repair associated. (3412 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (319 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
MAPK15Mitogen-activated protein kinase. (619 aa)
CHEK2Checkpoint kinase 2. (538 aa)
CDT1Chromatin licensing and DNA replication factor 1. (365 aa)
SOX15SRY-box transcription factor 15. (227 aa)
LOC103347509Uncharacterized protein. (314 aa)
RANBP1RAN binding protein 1. (266 aa)
RARARetinoic acid receptor alpha. (462 aa)
PRDM7KRAB-related domain-containing protein. (490 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (334 aa)
RAD51C-2RECA_2 domain-containing protein. (126 aa)
PPP1R35Protein phosphatase 1 regulatory subunit 35. (239 aa)
TRIM32Tripartite motif containing 32. (659 aa)
G1TLX8_RABITRING-type domain-containing protein. (248 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
GEN1GEN1 Holliday junction 5' flap endonuclease. (904 aa)
ANAPC11RING-type domain-containing protein. (84 aa)
G1TRH9_RABITUncharacterized protein. (116 aa)
CCNYCyclin Y; Belongs to the cyclin family. (363 aa)
ZBED6Zinc finger BED-type containing 6. (979 aa)
LOC100343361Uncharacterized protein. (254 aa)
G1TTM1_RABITBromo domain-containing protein. (95 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (487 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
CDC27Cell division cycle 27. (825 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
KIF3BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (951 aa)
ATAD5ATPase family AAA domain containing 5. (1846 aa)
GLI1GLI family zinc finger 1. (1103 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
G1TXW1_RABITCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
PAGR1PAXIP1 associated glutamate rich protein 1. (254 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1131 aa)
TBX2T-box transcription factor 2. (662 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (216 aa)
MAP10Microtubule associated protein 10. (832 aa)
CDC7Cell division cycle 7. (536 aa)
CENPVGFA domain-containing protein. (303 aa)
G1U1H6_RABITUncharacterized protein. (776 aa)
PHB2Prohibitin. (299 aa)
ECT2Epithelial cell transforming 2. (952 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
STAT5ASignal transducer and activator of transcription. (793 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
OOEPMOEP19 domain-containing protein. (218 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2116 aa)
XRCC3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (344 aa)
DDX39BDExD-box helicase 39B. (427 aa)
PRKCAProtein kinase C alpha type; Calcium-activated, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascades involving MAPK1/3 (ERK1/2) and RAP1GAP. Depending on the cell type, is involved in cell proliferation and cell growth arrest by positive and negative regul [...] (664 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
OVOL1Ovo like transcriptional repressor 1. (251 aa)
CDC42-2Uncharacterized protein. (222 aa)
ANKRD17Ankyrin repeat domain 17. (2493 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (1100 aa)
DBF4BDBF4 zinc finger B. (684 aa)
POLDIP2DNA polymerase delta interacting protein 2. (433 aa)
CRNNCornulin. (584 aa)
PRAP1Uncharacterized protein. (189 aa)
LOC100338666Nudix hydrolase domain-containing protein. (195 aa)
MACROH2A1H2A histone family member Y; Belongs to the histone H2A family. (418 aa)
RAB11BRas-related protein Rab-11A; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11A regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial c [...] (312 aa)
ENSOCUP00000027928Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (88 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
ENSOCUP00000028034ANK_REP_REGION domain-containing protein. (131 aa)
WIZUncharacterized protein. (1882 aa)
SHBSH2 domain-containing protein. (607 aa)
SPHK1Sphingosine kinase 1. (455 aa)
UBXN2BUBX domain protein 2B. (391 aa)
ENSOCUP00000030830Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (57 aa)
EPGNEpithelial mitogen. (188 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
MAD1L1Uncharacterized protein. (434 aa)
STXBP4Syntaxin binding protein 4. (555 aa)
THOC5THO complex 5. (748 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
HSF1Heat shock transcription factor 1. (680 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (780 aa)
RAD51BRAD51 paralog B. (350 aa)
SPDYCUncharacterized protein. (229 aa)
NCAPH2Non-SMC condensin II complex subunit H2. (691 aa)
ENSOCUP00000033208SMC_N domain-containing protein. (86 aa)
CCNT2Cyclin T2. (690 aa)
ENSOCUP00000033989Uncharacterized protein. (133 aa)
SIN3ASIN3 transcription regulator family member A. (1241 aa)
SMOC2Uncharacterized protein. (1119 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
BIRC5Uncharacterized protein. (164 aa)
NDC80NDC80 kinetochore complex component. (673 aa)
ENSOCUP00000035983Uncharacterized protein. (108 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1215 aa)
CEP295Centrosomal protein 295. (2459 aa)
ENSOCUP00000037105Uncharacterized protein. (78 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
RDXRadixin. (643 aa)
ENSOCUP00000037977ANK_REP_REGION domain-containing protein. (1153 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (391 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (620 aa)
RUNDC3BUncharacterized protein. (1064 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (287 aa)
CDC14BUncharacterized protein. (560 aa)
ENSOCUP00000038717Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (65 aa)
BTCBetacellulin. (212 aa)
ENSOCUP00000039146Uncharacterized protein. (151 aa)
NCAPHCondensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (734 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
DTLDenticleless E3 ubiquitin protein ligase homolog. (730 aa)
CPSF3Cleavage and polyadenylation specific factor 3. (809 aa)
SIRT2Sirtuin 2. (509 aa)
ENSOCUP00000039970Raptor_N domain-containing protein. (253 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (335 aa)
CUL4BCullin 4B; Belongs to the cullin family. (901 aa)
SMC4Structural maintenance of chromosomes protein. (1267 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (282 aa)
RB1RB transcriptional corepressor 1. (943 aa)
DYNC1LI1Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (586 aa)
PROX1Prospero homeobox 1. (737 aa)
MTBPMDM2 binding protein. (907 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000042026ANK_REP_REGION domain-containing protein. (555 aa)
CDC14ACell division cycle 14A. (625 aa)
INSRTyrosine-protein kinase receptor. (1377 aa)
ZBED6CLDimer_Tnp_hAT domain-containing protein. (1074 aa)
ENSOCUP00000043082Uncharacterized protein. (319 aa)
TGM1Protein-glutamine gamma-glutamyltransferase K; Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation (By similarity). (833 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (968 aa)
RCC2Regulator of chromosome condensation 2. (509 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (844 aa)
FAM178BUncharacterized protein. (460 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ENSOCUP00000047247ANK_REP_REGION domain-containing protein. (106 aa)
ENSOCUP00000047323Fork-head domain-containing protein. (261 aa)
CDC25ACell division cycle 25A. (491 aa)
CDC42Uncharacterized protein. (191 aa)
ENSOCUP00000047968Uncharacterized protein. (672 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
FBXO42F-box protein 42. (761 aa)
ENSOCUP00000048431Uncharacterized protein. (123 aa)
LFNGLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (403 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (485 aa)
HOXA13Homeobox A13. (222 aa)
ENSOCUP00000049162Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (793 aa)
KLHL18Kelch like family member 18. (555 aa)
C12H6orf89Uncharacterized protein. (311 aa)
PKN2Protein kinase N2. (996 aa)
ENSOCUP00000049983Uncharacterized protein. (319 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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