(41 nodes) Response to antibiotic network (Oryctolagus cuniculus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	RSRC1	Arginine and serine rich coiled-coil 1. (333 aa)
	ENSOCUP00000031750	Uncharacterized protein. (60 aa)
	CIITA	Class II major histocompatibility complex transactivator. (1175 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (614 aa)
	ZC3H8	Zinc finger CCCH-type containing 8. (355 aa)
	ENSOCUP00000035480	ANK_REP_REGION domain-containing protein. (132 aa)
	HSP90AA1	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...] (759 aa)
	ACTR2	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (425 aa)
	ALPL	Alkaline phosphatase. (558 aa)
	CBL	Cbl proto-oncogene. (837 aa)
	HYAL2	Hyaluronidase. (475 aa)
	HYAL1	Hyaluronidase. (497 aa)
	JAK1	Tyrosine-protein kinase. (1151 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1211 aa)
	KDM5B	Lysine demethylase 5B. (1537 aa)
	GJB2	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
	RPL23	Uncharacterized protein; Belongs to the universal ribosomal protein uL14 family. (140 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (198 aa)
	ATP7A	ATPase copper transporting alpha. (1499 aa)
	PLA2G4A	Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). (748 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
	AOC3	Amine oxidase; Belongs to the copper/topaquinone oxidase family. (763 aa)
	ENSOCUP00000045545	ANK_REP_REGION domain-containing protein. (123 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (466 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	UROS	HEM4 domain-containing protein. (481 aa)
	CYB5R4	Cytochrome b5 reductase 4. (520 aa)
	U3KM51_RABIT	Uncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (794 aa)
	HYAL3	Hyaluronidase. (492 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
	G1U940_RABIT	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
	SLC1A3	Amino acid transporter. (542 aa)
	G1TLX8_RABIT	RING-type domain-containing protein. (248 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
	LOC100341783	Uncharacterized protein; Belongs to the universal ribosomal protein uL14 family. (140 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (848 aa)
	VKORC1	Vitamin K epoxide reductase complex subunit 1. (162 aa)
	AOC1	Amine oxidase. (757 aa)
	LOC100350716	Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (808 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	PLA2G4F	Phospholipase A2. (897 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP9	G1TLX8_RABIT	ENSOCUP00000047129	ENSOCUP00000017982	Caspase 9; Belongs to the peptidase C14A family.	RING-type domain-containing protein.	0.419
CASP9	G1U940_RABIT	ENSOCUP00000047129	ENSOCUP00000025959	Caspase 9; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.591
CASP9	JAK1	ENSOCUP00000047129	ENSOCUP00000005398	Caspase 9; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.467
CASP9	JAK2	ENSOCUP00000047129	ENSOCUP00000014491	Caspase 9; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.594
CASP9	TP53	ENSOCUP00000047129	ENSOCUP00000000989	Caspase 9; Belongs to the peptidase C14A family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.709
CBL	JAK1	ENSOCUP00000004160	ENSOCUP00000005398	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.534
CBL	JAK2	ENSOCUP00000004160	ENSOCUP00000014491	Cbl proto-oncogene.	Tyrosine-protein kinase.	0.601
CDKN1B	G1TLX8_RABIT	ENSOCUP00000012008	ENSOCUP00000017982	Cyclin dependent kinase inhibitor 1B.	RING-type domain-containing protein.	0.435
CDKN1B	G1U940_RABIT	ENSOCUP00000012008	ENSOCUP00000025959	Cyclin dependent kinase inhibitor 1B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.680
CDKN1B	JAK1	ENSOCUP00000012008	ENSOCUP00000005398	Cyclin dependent kinase inhibitor 1B.	Tyrosine-protein kinase.	0.474
CDKN1B	JAK2	ENSOCUP00000012008	ENSOCUP00000014491	Cyclin dependent kinase inhibitor 1B.	Tyrosine-protein kinase.	0.469
CDKN1B	TP53	ENSOCUP00000012008	ENSOCUP00000000989	Cyclin dependent kinase inhibitor 1B.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.983
CIITA	JAK1	ENSOCUP00000029574	ENSOCUP00000005398	Class II major histocompatibility complex transactivator.	Tyrosine-protein kinase.	0.400
EHMT2	EZH2	ENSOCUP00000006046	ENSOCUP00000041806	Euchromatic histone lysine methyltransferase 2.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.510
EHMT2	G1U940_RABIT	ENSOCUP00000006046	ENSOCUP00000025959	Euchromatic histone lysine methyltransferase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.516
EHMT2	KDM1A	ENSOCUP00000006046	ENSOCUP00000001013	Euchromatic histone lysine methyltransferase 2.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.674
EHMT2	KDM5B	ENSOCUP00000006046	ENSOCUP00000006924	Euchromatic histone lysine methyltransferase 2.	Lysine demethylase 5B.	0.506
EHMT2	TP53	ENSOCUP00000006046	ENSOCUP00000000989	Euchromatic histone lysine methyltransferase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.517
ENSOCUP00000035480	G1U940_RABIT	ENSOCUP00000035480	ENSOCUP00000025959	ANK_REP_REGION domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.516
ENSOCUP00000035480	KDM1A	ENSOCUP00000035480	ENSOCUP00000001013	ANK_REP_REGION domain-containing protein.	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family.	0.500