(16 nodes) Response to copper ion network (Oryctolagus cuniculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Your Input:
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
	PAM	Peptidylglycine alpha-amidating monooxygenase. (975 aa)
	PRNP	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...] (252 aa)
	CDK1	Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (297 aa)
	DAXX	Death domain associated protein. (740 aa)
	ATP7A	ATPase copper transporting alpha. (1499 aa)
	AOC1	Amine oxidase. (757 aa)
	TFRC	Transferrin receptor. (763 aa)
	MT4	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (677 aa)
	HSF1	Heat shock transcription factor 1. (680 aa)
	GHRHR	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa)
	PARK7	Parkinsonism associated deglycase. (231 aa)
	LOXL3	Lysyl oxidase like 3. (935 aa)
	ATP7B	ATPase copper transporting beta. (1465 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP7A	ATP7B	ENSOCUP00000012171	ENSOCUP00000043559	ATPase copper transporting alpha.	ATPase copper transporting beta.	0.905
ATP7A	MT4	ENSOCUP00000012171	ENSOCUP00000014837	ATPase copper transporting alpha.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.728
ATP7A	PAM	ENSOCUP00000012171	ENSOCUP00000001375	ATPase copper transporting alpha.	Peptidylglycine alpha-amidating monooxygenase.	0.661
ATP7A	TFRC	ENSOCUP00000012171	ENSOCUP00000014641	ATPase copper transporting alpha.	Transferrin receptor.	0.419
ATP7B	ATP7A	ENSOCUP00000043559	ENSOCUP00000012171	ATPase copper transporting beta.	ATPase copper transporting alpha.	0.905
ATP7B	MT4	ENSOCUP00000043559	ENSOCUP00000014837	ATPase copper transporting beta.	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	0.741
ATP7B	PAM	ENSOCUP00000043559	ENSOCUP00000001375	ATPase copper transporting beta.	Peptidylglycine alpha-amidating monooxygenase.	0.429
BACE1	PRNP	ENSOCUP00000025190	ENSOCUP00000001797	Beta-secretase 1; Belongs to the peptidase A1 family.	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...]	0.710
BACE1	TFRC	ENSOCUP00000025190	ENSOCUP00000014641	Beta-secretase 1; Belongs to the peptidase A1 family.	Transferrin receptor.	0.676
DAXX	PARK7	ENSOCUP00000009116	ENSOCUP00000039196	Death domain associated protein.	Parkinsonism associated deglycase.	0.929
MT4	ATP7A	ENSOCUP00000014837	ENSOCUP00000012171	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	ATPase copper transporting alpha.	0.728
MT4	ATP7B	ENSOCUP00000014837	ENSOCUP00000043559	Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals.	ATPase copper transporting beta.	0.741
NFE2L2	PARK7	ENSOCUP00000026975	ENSOCUP00000039196	Nuclear factor, erythroid 2 like 2.	Parkinsonism associated deglycase.	0.934
PAM	ATP7A	ENSOCUP00000001375	ENSOCUP00000012171	Peptidylglycine alpha-amidating monooxygenase.	ATPase copper transporting alpha.	0.661
PAM	ATP7B	ENSOCUP00000001375	ENSOCUP00000043559	Peptidylglycine alpha-amidating monooxygenase.	ATPase copper transporting beta.	0.429
PARK7	DAXX	ENSOCUP00000039196	ENSOCUP00000009116	Parkinsonism associated deglycase.	Death domain associated protein.	0.929
PARK7	NFE2L2	ENSOCUP00000039196	ENSOCUP00000026975	Parkinsonism associated deglycase.	Nuclear factor, erythroid 2 like 2.	0.934
PRNP	BACE1	ENSOCUP00000001797	ENSOCUP00000025190	Major prion protein; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan s [...]	Beta-secretase 1; Belongs to the peptidase A1 family.	0.710
TFRC	ATP7A	ENSOCUP00000014641	ENSOCUP00000012171	Transferrin receptor.	ATPase copper transporting alpha.	0.419
TFRC	BACE1	ENSOCUP00000014641	ENSOCUP00000025190	Transferrin receptor.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.676