STRINGSTRING
NODAL NODAL NKX3-2 NKX3-2 ADA ADA VPS52 VPS52 BMP4 BMP4 SMAD2 SMAD2 TGFB3 TGFB3 SOX9 SOX9 KIT KIT CCDC39 CCDC39 FGFR2 FGFR2 CTNNB1 CTNNB1 LOC103345451 LOC103345451 CLDN18 CLDN18 SAV1 SAV1 TGFBR2 TGFBR2 BCL2 BCL2 ENSOCUP00000037329 ENSOCUP00000037329 RB1 RB1 HIF1A HIF1A ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000042043 ENSOCUP00000042043 ENSOCUP00000042867 ENSOCUP00000042867 ENSOCUP00000042987 ENSOCUP00000042987 OVOL2 OVOL2 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 GLI2 GLI2 TP63 TP63 HOXA13 HOXA13 CPS1 CPS1 AHI1 AHI1 KLF5 KLF5 SOX10 SOX10 EPHB3 EPHB3 SOX17 SOX17 PKD1 PKD1 NPHP3 NPHP3 COL3A1 COL3A1 DACT1 DACT1 EXT1 EXT1 G1TBJ9_RABIT G1TBJ9_RABIT SFRP2 SFRP2 SHH SHH ALDH1A2 ALDH1A2 PDGFC PDGFC TCF21 TCF21 EDNRB EDNRB MEGF8 MEGF8 ZIC3 ZIC3 HOXA5 HOXA5 MYOCD MYOCD ENSOCUP00000024205 ENSOCUP00000024205 IHH IHH PCSK5 PCSK5 HOXD13 HOXD13 COBL COBL SMO SMO SMAD3 SMAD3 FOXF1 FOXF1 CBFA2T2 CBFA2T2 CRKL CRKL RARB RARB OTC OTC WNT5A WNT5A PDGFRA PDGFRA SHOX2 SHOX2 PRDM1 PRDM1 YIPF6 YIPF6 ASS1 ASS1 ENSOCUP00000029917 ENSOCUP00000029917 SOX11 SOX11 DNAAF1 DNAAF1 CHD8 CHD8 C1GALT1 C1GALT1 CXCL8 CXCL8 FOXF2 FOXF2 STRA6 STRA6 ID2 ID2 MIXL1 MIXL1 SIX2 SIX2 CCDC103 CCDC103 HES1 HES1 WNT11 WNT11 TIGAR TIGAR GATA4 GATA4 SALL1 SALL1 PKDCC PKDCC LGR4 LGR4 NKX2-6 NKX2-6 IFT172 IFT172 PDX1 PDX1 CDX2 CDX2 TGFB2 TGFB2 HMGCS2 HMGCS2 NIPBL NIPBL HLX HLX GLI3 GLI3 TNF TNF ALX4 ALX4 TBX2 TBX2 LINS1 LINS1 CCKBR CCKBR IL6ST IL6ST EPB41L5 EPB41L5 G1SV95_RABIT G1SV95_RABIT FGF10 FGF10 TYMS TYMS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NODALNodal growth differentiation factor. (348 aa)
NKX3-2NK3 homeobox 2. (333 aa)
ADAAdenosine deaminase. (363 aa)
VPS52VPS52 subunit of GARP complex. (723 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
SOX9SRY-box transcription factor 9. (496 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
CCDC39Coiled-coil domain containing 39. (939 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
CTNNB1Catenin beta 1. (741 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
SAV1Salvador family WW domain containing protein 1. (392 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
RB1RB transcriptional corepressor 1. (943 aa)
HIF1AUncharacterized protein. (851 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000042043Ig-like domain-containing protein. (212 aa)
ENSOCUP00000042867Uncharacterized protein. (340 aa)
ENSOCUP00000042987Thymidylat_synt domain-containing protein. (98 aa)
OVOL2Ovo like zinc finger 2. (333 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
GLI2GLI family zinc finger 2. (1575 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
HOXA13Homeobox A13. (222 aa)
CPS1Carbamoyl-phosphate synthase 1. (1506 aa)
AHI1Abelson helper integration site 1. (1188 aa)
KLF5Uncharacterized protein. (457 aa)
SOX10SRY-box transcription factor 10. (466 aa)
EPHB3EPH receptor B3. (1075 aa)
SOX17HMG box domain-containing protein. (165 aa)
PKD1Uncharacterized protein. (2465 aa)
NPHP3TPR_REGION domain-containing protein. (1218 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (844 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
G1TBJ9_RABITUncharacterized protein. (276 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (590 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
TCF21Transcription factor 21. (179 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. (441 aa)
MEGF8Uncharacterized protein. (439 aa)
ZIC3Zic family member 3. (467 aa)
HOXA5Homeobox A5. (381 aa)
MYOCDMyocardin. (989 aa)
ENSOCUP00000024205annotation not available (363 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (1859 aa)
HOXD13Homeobox D13. (204 aa)
COBLCordon-bleu WH2 repeat protein. (1335 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
SMAD3SMAD family member 3. (230 aa)
FOXF1Forkhead box F1. (433 aa)
CBFA2T2CBFA2/RUNX1 partner transcriptional co-repressor 2. (630 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
RARBRetinoic acid receptor beta. (448 aa)
OTCOrnithine carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (360 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
SHOX2Short stature homeobox 2. (211 aa)
PRDM1PR/SET domain 1. (889 aa)
YIPF6Protein YIPF. (292 aa)
ASS1Uncharacterized protein. (251 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
SOX11Transcription factor SOX. (446 aa)
DNAAF1Dynein assembly factor 1, axonemal. (368 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2458 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (389 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FOXF2Forkhead box F2. (520 aa)
STRA6Stimulated by retinoic acid 6. (729 aa)
ID2Inhibitor of DNA binding 2. (109 aa)
MIXL1Mix paired-like homeobox. (234 aa)
SIX2SIX homeobox 2. (295 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (265 aa)
GATA4GATA binding protein 4. (444 aa)
SALL1Uncharacterized protein. (1234 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (372 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
NKX2-6NK2 homeobox 6. (294 aa)
IFT172Intraflagellar transport 172. (1749 aa)
PDX1Pancreatic and duodenal homeobox 1. (336 aa)
CDX2Caudal type homeobox 2. (314 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (534 aa)
NIPBLNipped-B protein. (2580 aa)
HLXH2.0 like homeobox. (682 aa)
GLI3GLI family zinc finger 3. (1575 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
ALX4ALX homeobox 4. (397 aa)
TBX2T-box transcription factor 2. (662 aa)
LINS1Lines homolog 1. (618 aa)
CCKBRGastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CCK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (454 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
EPB41L5Erythrocyte membrane protein band 4.1 like 5. (731 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
TYMSThymidylate synthetase. (310 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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