STRINGSTRING
RYR2 RYR2 POU4F1 POU4F1 ANKRD1 ANKRD1 ENG ENG ACTC1 ACTC1 TNNC1 TNNC1 G1SV95_RABIT G1SV95_RABIT CHD7 CHD7 BMP10 BMP10 TNNI1 TNNI1 DLL4 DLL4 LRP2 LRP2 HAND1 HAND1 DSP DSP EGLN1 EGLN1 TPM1 TPM1 TBX1 TBX1 COL3A1 COL3A1 S1PR1 S1PR1 TGFBR3 TGFBR3 WNT2 WNT2 G1TBJ9_RABIT G1TBJ9_RABIT BMPR1A BMPR1A TCF15 TCF15 SMAD7 SMAD7 TNNT2 TNNT2 G1TQE3_RABIT G1TQE3_RABIT ISL1 ISL1 MYL10 MYL10 GSC GSC MED1 MED1 SMTNL1 SMTNL1 TCAP TCAP MYF5 MYF5 SHOX2 SHOX2 HEY2 HEY2 MYL3 MYL3 TBX20 TBX20 ARID5B ARID5B PKP2 PKP2 ENSOCUP00000031621 ENSOCUP00000031621 LOC103345451 LOC103345451 COL11A1 COL11A1 ENSOCUP00000033859 ENSOCUP00000033859 NRG1 NRG1 FGFR2 FGFR2 TGFBR1 TGFBR1 ENSOCUP00000037329 ENSOCUP00000037329 PROX1 PROX1 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000044284 ENSOCUP00000044284 XIRP2 XIRP2 ENSOCUP00000045925 ENSOCUP00000045925 ADARB1 ADARB1 LIF LIF SMAD4 SMAD4 TGFB2 TGFB2 CNTF CNTF ZFPM2 ZFPM2 NKX2-5 NKX2-5 WNT5A WNT5A EDNRA EDNRA MYF6 MYF6 MYBPC3 MYBPC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYR2Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] (4965 aa)
POU4F1POU domain protein. (339 aa)
ANKRD1Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (319 aa)
ENGEndoglin. (758 aa)
ACTC1Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (161 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
BMP10Bone morphogenetic protein 10. (428 aa)
TNNI1Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (187 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
LRP2Uncharacterized protein. (2726 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (215 aa)
DSPDesmoplakin. (2814 aa)
EGLN1Uncharacterized protein. (457 aa)
TPM1Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
TBX1Uncharacterized protein. (440 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
S1PR1Uncharacterized protein. (356 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
G1TBJ9_RABITUncharacterized protein. (276 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TCF15Transcription factor 15. (199 aa)
SMAD7Mothers against decapentaplegic homolog. (549 aa)
TNNT2Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (341 aa)
G1TQE3_RABITFork-head domain-containing protein. (520 aa)
ISL1ISL LIM homeobox 1. (349 aa)
MYL10Myosin light chain 10. (167 aa)
GSCGoosecoid homeobox. (237 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
SMTNL1Smoothelin like 1. (459 aa)
TCAPTitin-cap. (179 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
SHOX2Short stature homeobox 2. (211 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
MYL3Myosin light chain 3. (327 aa)
TBX20T-box transcription factor 20. (460 aa)
ARID5BAT-rich interaction domain 5B. (1191 aa)
PKP2Plakophilin 2. (773 aa)
ENSOCUP00000031621Uncharacterized protein. (1225 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
COL11A1Collagen type XI alpha 1 chain. (1857 aa)
ENSOCUP00000033859Uncharacterized protein. (176 aa)
NRG1Neuregulin 1. (720 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
XIRP2Xin actin binding repeat containing 2. (3529 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ADARB1Adenosine deaminase RNA specific B1. (837 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (199 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1159 aa)
NKX2-5NK2 homeobox 5. (326 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
MYF6Myogenic factor 6. (242 aa)
MYBPC3Myosin binding protein C, cardiac. (1250 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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