37 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TFAP2A	Transcription factor AP-2 alpha. (732 aa)
	PDGFRA	Protein kinase domain-containing protein. (773 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (979 aa)
	SETD2	Uncharacterized protein. (625 aa)
	IRX5	Iroquois homeobox 5. (439 aa)
	WDR19	WD repeat domain 19. (1342 aa)
	GRHL2	Grainyhead like transcription factor 2. (728 aa)
	NIPBL	Nipped-B protein. (2580 aa)
	GLI3	GLI family zinc finger 3. (1575 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	ALX3	ALX homeobox 3. (343 aa)
	BMP4	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
	MMP16	Matrix metallopeptidase 16. (607 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	PRRX1	Paired related homeobox 1. (278 aa)
	PAX5	Paired box 5. (371 aa)
	TBX15	T-box transcription factor 15. (602 aa)
	SIX1	SIX homeobox 1. (284 aa)
	TBX1	Uncharacterized protein. (440 aa)
	HOXA2	Homeobox domain-containing protein. (374 aa)
	LOC100346323	Uncharacterized protein. (240 aa)
	IFT140	Intraflagellar transport 140. (1460 aa)
	SLC39A1	Solute carrier family 39 member 1. (327 aa)
	HOXA1	Homeobox A1 isoform a (Predicted). (337 aa)
	SIX2	SIX homeobox 2. (295 aa)
	G1U373_RABIT	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
	SMAD3	SMAD family member 3. (230 aa)
	TGFBR2	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
	NDST1	N-deacetylase and N-sulfotransferase 1. (929 aa)
	FGFR2	Fibroblast growth factor receptor. (894 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (614 aa)
	ENSOCUP00000042043	Ig-like domain-containing protein. (212 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (431 aa)
	MED12	Mediator complex subunit 12. (2142 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	FGFR2	ENSOCUP00000009545	ENSOCUP00000034244	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Fibroblast growth factor receptor.	0.607
BMP4	G1U373_RABIT	ENSOCUP00000009545	ENSOCUP00000023832	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family.	0.464
BMP4	GLI3	ENSOCUP00000009545	ENSOCUP00000005676	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	GLI family zinc finger 3.	0.561
BMP4	PDGFRA	ENSOCUP00000009545	ENSOCUP00000000224	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Protein kinase domain-containing protein.	0.540
BMP4	SIX1	ENSOCUP00000009545	ENSOCUP00000012260	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	SIX homeobox 1.	0.538
BMP4	SIX2	ENSOCUP00000009545	ENSOCUP00000021355	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	SIX homeobox 2.	0.526
BMP4	SMAD2	ENSOCUP00000009545	ENSOCUP00000009717	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Mothers against decapentaplegic homolog.	0.869
BMP4	SMAD3	ENSOCUP00000009545	ENSOCUP00000027151	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	SMAD family member 3.	0.819
BMP4	TFAP2A	ENSOCUP00000009545	ENSOCUP00000040507	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Transcription factor AP-2 alpha.	0.434
BMP4	TGFBR1	ENSOCUP00000009545	ENSOCUP00000035624	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily.	0.816
BMP4	TGFBR2	ENSOCUP00000009545	ENSOCUP00000030537	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...]	0.643
ENSOCUP00000042043	FGFR2	ENSOCUP00000042043	ENSOCUP00000034244	Ig-like domain-containing protein.	Fibroblast growth factor receptor.	0.418
ENSOCUP00000042043	G1U373_RABIT	ENSOCUP00000042043	ENSOCUP00000023832	Ig-like domain-containing protein.	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family.	0.526
ENSOCUP00000042043	PDGFRA	ENSOCUP00000042043	ENSOCUP00000000224	Ig-like domain-containing protein.	Protein kinase domain-containing protein.	0.900
FGFR2	BMP4	ENSOCUP00000034244	ENSOCUP00000009545	Fibroblast growth factor receptor.	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	0.607
FGFR2	ENSOCUP00000042043	ENSOCUP00000034244	ENSOCUP00000042043	Fibroblast growth factor receptor.	Ig-like domain-containing protein.	0.418
FGFR2	G1U373_RABIT	ENSOCUP00000034244	ENSOCUP00000023832	Fibroblast growth factor receptor.	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family.	0.944
FGFR2	PDGFRA	ENSOCUP00000034244	ENSOCUP00000000224	Fibroblast growth factor receptor.	Protein kinase domain-containing protein.	0.627
G1U373_RABIT	BMP4	ENSOCUP00000023832	ENSOCUP00000009545	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity).	0.464
G1U373_RABIT	ENSOCUP00000042043	ENSOCUP00000023832	ENSOCUP00000042043	SRCR domain-containing protein; Belongs to the heparin-binding growth factors family.	Ig-like domain-containing protein.	0.526