STRINGSTRING
TGFBR2 TGFBR2 ENSOCUP00000031222 ENSOCUP00000031222 FLVCR1 FLVCR1 ENSOCUP00000031395 ENSOCUP00000031395 NDST1 NDST1 SOX6 SOX6 LOC103345451 LOC103345451 ENSOCUP00000032400 ENSOCUP00000032400 COL11A1 COL11A1 TIPARP TIPARP THRA THRA CTNNB1 CTNNB1 EXT2 EXT2 FGF18 FGF18 TRIP11 TRIP11 FGFR2 FGFR2 NAB2 NAB2 FOXN3 FOXN3 HOXC4 HOXC4 ENSOCUP00000035026 ENSOCUP00000035026 CYP26B1 CYP26B1 PAX1 PAX1 TGFBR1 TGFBR1 ENSOCUP00000036322 ENSOCUP00000036322 BMPR2 BMPR2 DLX5 DLX5 OTOR OTOR ENSOCUP00000037329 ENSOCUP00000037329 COL13A1 COL13A1 TFAP2A TFAP2A SOX5 SOX5 SPEF2 SPEF2 TULP3 TULP3 INPPL1 INPPL1 PDGFRA PDGFRA TBXT TBXT RARB RARB ZFAND5 ZFAND5 HOXC11 HOXC11 HOXB1 HOXB1 FGF6 FGF6 HOXD4 HOXD4 MMP13 MMP13 WWOX WWOX MTHFD1L MTHFD1L SETD2 SETD2 ANKRD11 ANKRD11 IRX5 IRX5 BMP6 BMP6 GLG1 GLG1 TRPV4 TRPV4 ALPL ALPL COL27A1 COL27A1 WDR19 WDR19 HOXC8 HOXC8 GRHL2 GRHL2 RAB23 RAB23 HYAL2 HYAL2 ANXA6 ANXA6 PEX7 PEX7 WDR48 WDR48 PRKRA PRKRA HYAL1 HYAL1 STC1 STC1 NIPBL NIPBL OSR1 OSR1 ZEB1 ZEB1 GLI3 GLI3 G1SSE9_RABIT G1SSE9_RABIT ALX4 ALX4 MATN1 MATN1 ENSOCUP00000041840 ENSOCUP00000041840 RARG RARG ENSOCUP00000042043 ENSOCUP00000042043 BMPR1B BMPR1B ENSOCUP00000044284 ENSOCUP00000044284 PPARGC1B PPARGC1B TMEM107 TMEM107 PLEKHA1 PLEKHA1 WNT9B WNT9B RDH10 RDH10 G1SV95_RABIT G1SV95_RABIT NAB1 NAB1 ATG9B ATG9B NODAL NODAL P2RX7 P2RX7 FGR FGR HOXD10 HOXD10 NKX3-2 NKX3-2 EYA1 EYA1 WNT10B WNT10B ALX3 ALX3 WDR60 WDR60 THBS3 THBS3 DSCAML1 DSCAML1 CER1 CER1 FREM1 FREM1 TBX4 TBX4 BMP4 BMP4 MMP16 MMP16 SMAD2 SMAD2 TGFB3 TGFB3 HOXB6 HOXB6 SMPD3 SMPD3 ATF2 ATF2 MEF2D MEF2D PRRX1 PRRX1 PAX5 PAX5 TBX15 TBX15 CDX1 CDX1 PKD1 PKD1 COL2A1 COL2A1 INSIG1 INSIG1 HOXD11 HOXD11 SIX1 SIX1 NLE1 NLE1 NPPC NPPC TBX1 TBX1 PSEN1 PSEN1 IFT80 IFT80 COL3A1 COL3A1 ATG9A ATG9A HOXA11 HOXA11 HOXA7 HOXA7 EXT1 EXT1 HOXA2 HOXA2 PAPPA2 PAPPA2 ZMPSTE24 ZMPSTE24 SFRP4 SFRP4 PHOSPHO1 PHOSPHO1 G1TBJ9_RABIT G1TBJ9_RABIT COL11A2 COL11A2 LOC100346323 LOC100346323 MEGF8 MEGF8 DSPP DSPP HOXB2 HOXB2 HOXA3 HOXA3 SOX11 SOX11 LTF LTF HOXB5 HOXB5 HOXB8 HOXB8 RARA RARA HOXB3 HOXB3 SCUBE2 SCUBE2 TCF15 TCF15 FGF4 FGF4 CSRNP1 CSRNP1 BARX2 BARX2 TIFAB TIFAB HOXD9 HOXD9 OSR2 OSR2 IFT140 IFT140 SLC39A1 SLC39A1 HOXA1 HOXA1 HOXD3 HOXD3 HOXC9 HOXC9 GSC GSC SERPINH1 SERPINH1 G1TVI4_RABIT G1TVI4_RABIT RYK RYK ENSOCUP00000045925 ENSOCUP00000045925 ANKRD12 ANKRD12 SIX2 SIX2 BMP7 BMP7 PCGF2 PCGF2 RFLNB RFLNB HAS2 HAS2 G1U106_RABIT G1U106_RABIT TMEM119 TMEM119 AXIN2 AXIN2 MEF2C MEF2C MED12 MED12 CITED2 CITED2 MDFI MDFI HHIP HHIP MYF5 MYF5 HOXA5 HOXA5 G1U373_RABIT G1U373_RABIT ACTN3 ACTN3 IHH IHH HOXB9 HOXB9 DHRS3 DHRS3 CHSY1 CHSY1 SMAD3 SMAD3 SHOX2 SHOX2 ENSOCUP00000028861 ENSOCUP00000028861 IMPAD1 IMPAD1 ENSOCUP00000029917 ENSOCUP00000029917 ARID5B ARID5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSOCUP00000031222ANK_REP_REGION domain-containing protein. (421 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (552 aa)
ENSOCUP00000031395Uncharacterized protein; Belongs to the serpin family. (216 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (929 aa)
SOX6SRY-box transcription factor 6. (855 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
COL11A1Collagen type XI alpha 1 chain. (1857 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (685 aa)
THRAThyroid hormone receptor alpha. (452 aa)
CTNNB1Catenin beta 1. (741 aa)
EXT2Exostosin glycosyltransferase 2. (1147 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
TRIP11Thyroid hormone receptor interactor 11. (1982 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
NAB2NGFI-A binding protein 2. (545 aa)
FOXN3Forkhead box N3. (498 aa)
HOXC4Homeobox C4. (264 aa)
ENSOCUP00000035026Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (299 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (709 aa)
PAX1Paired box 1. (431 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
ENSOCUP00000036322A20-type domain-containing protein. (114 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
DLX5Distal-less homeobox 5. (313 aa)
OTOROtoraplin. (177 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
COL13A1Uncharacterized protein. (472 aa)
TFAP2ATranscription factor AP-2 alpha. (732 aa)
SOX5SRY-box transcription factor 5. (779 aa)
SPEF2Sperm flagellar 2. (2112 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (614 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1362 aa)
PDGFRAProtein kinase domain-containing protein. (773 aa)
TBXTT-box transcription factor T. (365 aa)
RARBRetinoic acid receptor beta. (448 aa)
ZFAND5Zinc finger AN1-type containing 5. (213 aa)
HOXC11Homeobox C11. (303 aa)
HOXB1Homeobox B1. (300 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HOXD4Homeobox D4. (242 aa)
MMP13Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (471 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (979 aa)
SETD2Uncharacterized protein. (625 aa)
ANKRD11Uncharacterized protein. (1815 aa)
IRX5Iroquois homeobox 5. (439 aa)
BMP6Bone morphogenetic protein 6. (411 aa)
GLG1Golgi glycoprotein 1. (1225 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (679 aa)
ALPLAlkaline phosphatase. (558 aa)
COL27A1LAM_G_DOMAIN domain-containing protein. (1333 aa)
WDR19WD repeat domain 19. (1342 aa)
HOXC8Homeobox C8. (242 aa)
GRHL2Grainyhead like transcription factor 2. (728 aa)
RAB23RAB23, member RAS oncogene family. (248 aa)
HYAL2Hyaluronidase. (475 aa)
ANXA6Annexin. (913 aa)
PEX7Peroxisomal biogenesis factor 7. (323 aa)
WDR48WD repeat domain 48. (867 aa)
PRKRAProtein activator of interferon induced protein kinase EIF2AK2. (312 aa)
HYAL1Hyaluronidase. (497 aa)
STC1Stanniocalcin 1. (247 aa)
NIPBLNipped-B protein. (2580 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
GLI3GLI family zinc finger 3. (1575 aa)
G1SSE9_RABITUncharacterized protein. (296 aa)
ALX4ALX homeobox 4. (397 aa)
MATN1Matrilin 1. (724 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RARGUncharacterized protein. (415 aa)
ENSOCUP00000042043Ig-like domain-containing protein. (212 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
PPARGC1BPPARG coactivator 1 beta. (1125 aa)
TMEM107Transmembrane protein 107. (140 aa)
PLEKHA1Pleckstrin homology domain containing A1. (405 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (431 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
NAB1NGFI-A binding protein 1. (486 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (923 aa)
NODALNodal growth differentiation factor. (348 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
FGRTyrosine-protein kinase. (527 aa)
HOXD10Homeobox domain-containing protein. (410 aa)
NKX3-2NK3 homeobox 2. (333 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
ALX3ALX homeobox 3. (343 aa)
WDR60WD repeat domain 60. (1070 aa)
THBS3Thrombospondin 3. (911 aa)
DSCAML1DS cell adhesion molecule like 1. (2112 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
TBX4T-box transcription factor 4. (550 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
HOXB6Homeobox B6. (224 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (657 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
MEF2DMyocyte enhancer factor 2D. (517 aa)
PRRX1Paired related homeobox 1. (278 aa)
PAX5Paired box 5. (371 aa)
TBX15T-box transcription factor 15. (602 aa)
CDX1Caudal type homeobox 1. (266 aa)
PKD1Uncharacterized protein. (2465 aa)
COL2A1Fibrillar collagen NC1 domain-containing protein. (1487 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (292 aa)
HOXD11Homeobox domain-containing protein. (338 aa)
SIX1SIX homeobox 1. (284 aa)
NLE1Notchless homolog 1. (485 aa)
NPPCUncharacterized protein. (351 aa)
TBX1Uncharacterized protein. (440 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
IFT80Intraflagellar transport 80. (777 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
HOXA11Homeobox A11 (Predicted). (312 aa)
HOXA7Homeobox domain-containing protein. (234 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
HOXA2Homeobox domain-containing protein. (374 aa)
PAPPA2Pappalysin 2. (1669 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (267 aa)
G1TBJ9_RABITUncharacterized protein. (276 aa)
COL11A2Collagen type XI alpha 2 chain. (1656 aa)
LOC100346323Uncharacterized protein. (240 aa)
MEGF8Uncharacterized protein. (439 aa)
DSPPUncharacterized protein. (657 aa)
HOXB2Homeobox B2. (344 aa)
HOXA3Homeobox domain-containing protein. (440 aa)
SOX11Transcription factor SOX. (446 aa)
LTFLactotransferrin; Belongs to the transferrin family. (708 aa)
HOXB5Homeobox B5. (269 aa)
HOXB8Homeobox B8. (151 aa)
RARARetinoic acid receptor alpha. (462 aa)
HOXB3Homeobox B3. (434 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1024 aa)
TCF15Transcription factor 15. (199 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
CSRNP1Cysteine and serine rich nuclear protein 1. (540 aa)
BARX2BARX homeobox 2. (278 aa)
TIFABUncharacterized protein. (288 aa)
HOXD9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (248 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
IFT140Intraflagellar transport 140. (1460 aa)
SLC39A1Solute carrier family 39 member 1. (327 aa)
HOXA1Homeobox A1 isoform a (Predicted). (337 aa)
HOXD3Homeobox D3. (498 aa)
HOXC9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
GSCGoosecoid homeobox. (237 aa)
SERPINH1SERPIN domain-containing protein; Belongs to the serpin family. (201 aa)
G1TVI4_RABITNR LBD domain-containing protein. (321 aa)
RYKReceptor like tyrosine kinase. (553 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ANKRD12Ankyrin repeat domain 12. (2055 aa)
SIX2SIX homeobox 2. (295 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
PCGF2Polycomb group ring finger 2. (324 aa)
RFLNBRefilin B. (214 aa)
HAS2Uncharacterized protein. (556 aa)
G1U106_RABITUncharacterized protein. (312 aa)
TMEM119Transmembrane protein 119. (337 aa)
AXIN2Axin 2. (816 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MED12Mediator complex subunit 12. (2142 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
MDFIMyoD family inhibitor (Predicted). (246 aa)
HHIPHedgehog interacting protein. (700 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
HOXA5Homeobox A5. (381 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (900 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
DHRS3Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (311 aa)
CHSY1Hexosyltransferase. (751 aa)
SMAD3SMAD family member 3. (230 aa)
SHOX2Short stature homeobox 2. (211 aa)
ENSOCUP00000028861SERPIN domain-containing protein; Belongs to the serpin family. (321 aa)
IMPAD1Inositol monophosphatase domain containing 1. (368 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
ARID5BAT-rich interaction domain 5B. (1191 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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