STRINGSTRING
G1SV95_RABIT G1SV95_RABIT WNT5A WNT5A FGF2 FGF2 NAGLU NAGLU FOXI1 FOXI1 PHOX2B PHOX2B TSHR TSHR NOX3 NOX3 CLRN2 CLRN2 SLC9A3R1 SLC9A3R1 PDGFRB PDGFRB RPGRIP1L RPGRIP1L REST REST TBX18 TBX18 STOX1 STOX1 PTK7 PTK7 JAG1 JAG1 LIN7A LIN7A PTPN11 PTPN11 WHRN WHRN TGFB2 TGFB2 PJVK PJVK HESX1 HESX1 WDPCP WDPCP CALB1 CALB1 ZEB1 ZEB1 GLI3 GLI3 G1SRF3_RABIT G1SRF3_RABIT DVL2 DVL2 CLDN7 CLDN7 LOC100344381 LOC100344381 LRIG1 LRIG1 FREM2 FREM2 IFT20 IFT20 FGF10 FGF10 DLX6 DLX6 PLPPR4 PLPPR4 EYA1 EYA1 FZD6 FZD6 TMC1 TMC1 SPRY2 SPRY2 CHD7 CHD7 GJB2 GJB2 SLC26A5 SLC26A5 FRZB FRZB BMP4 BMP4 TGFB3 TGFB3 LHFPL5 LHFPL5 AHI1 AHI1 OC90 OC90 PRRX1 PRRX1 PAX2 PAX2 GABRA5 GABRA5 GBX2 GBX2 ATOH1 ATOH1 CLRN1 CLRN1 G1T5T5_RABIT G1T5T5_RABIT COL2A1 COL2A1 HPCA HPCA INSIG1 INSIG1 CDKN1B CDKN1B MAPKAPK2 MAPKAPK2 SIX1 SIX1 TBX1 TBX1 TBX3 TBX3 USH2A USH2A CEP290 CEP290 SLC44A4 SLC44A4 TTC8 TTC8 LRIG3 LRIG3 GRXCR2 GRXCR2 KCNQ4 KCNQ4 LRP10 LRP10 SHH SHH ADGRV1 ADGRV1 MYO3A MYO3A PLS1 PLS1 GATA3 GATA3 TSKU TSKU NTN1 NTN1 OTX1 OTX1 SOD1 SOD1 GJB6 GJB6 MYO3B MYO3B HPCAL1 HPCAL1 MYO7A MYO7A POU4F3 POU4F3 KCNK3 KCNK3 TIFAB TIFAB ATP6V1B1 ATP6V1B1 C1QTNF5 C1QTNF5 EYA4 EYA4 G1TT13_RABIT G1TT13_RABIT HOXA1 HOXA1 GRXCR1 GRXCR1 CHRNA9 CHRNA9 G1TV27_RABIT G1TV27_RABIT OTOP1 OTOP1 TCAP TCAP HES1 HES1 BLOC1S5 BLOC1S5 ATG4B ATG4B TBX2 TBX2 MAFB MAFB MYO6 MYO6 G1U373_RABIT G1U373_RABIT ROR1 ROR1 WNT1 WNT1 FZD3 FZD3 OTOL1 OTOL1 PTPRQ PTPRQ BMPER BMPER ANP32B ANP32B BCR BCR MPV17 MPV17 HEY2 HEY2 SEC24B SEC24B TTC39C TTC39C ENSOCUP00000031477 ENSOCUP00000031477 LOC103345451 LOC103345451 SOBP SOBP IFT27 IFT27 GRHL3 GRHL3 RIPOR2 RIPOR2 SDC4 SDC4 COL11A1 COL11A1 SLC4A7 SLC4A7 MCM2 MCM2 ENSOCUP00000033288 ENSOCUP00000033288 USH1C USH1C ENSOCUP00000033989 ENSOCUP00000033989 TRIP11 TRIP11 FGFR2 FGFR2 SLC17A8 SLC17A8 ENSOCUP00000034581 ENSOCUP00000034581 KCNK2 KCNK2 ENSOCUP00000036498 ENSOCUP00000036498 DLX5 DLX5 LGR5 LGR5 ENSOCUP00000037329 ENSOCUP00000037329 ADAM10 ADAM10 CCM2 CCM2 ENSOCUP00000038760 ENSOCUP00000038760 CYTL1 CYTL1 PDZD7 PDZD7 HMX3 HMX3 KCNQ1 KCNQ1 TFAP2A TFAP2A GABRB2 GABRB2 DUOX2 DUOX2 PROX1 PROX1 ESRRB ESRRB DLL1 DLL1 ENSOCUP00000041840 ENSOCUP00000041840 IFT88 IFT88 LRRC1 LRRC1 CECR2 CECR2 MKS1 MKS1 ATG5 ATG5 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000044611 ENSOCUP00000044611 C1QB C1QB TRIOBP TRIOBP GSDME GSDME CDH23 CDH23 HPN HPN ENSOCUP00000045925 ENSOCUP00000045925 ITGA8 ITGA8 ENSOCUP00000047323 ENSOCUP00000047323 PAX8 PAX8 ENSOCUP00000048239 ENSOCUP00000048239 SLITRK6 SLITRK6 HOXA13 HOXA13 TMIE TMIE PCDH15 PCDH15
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (743 aa)
FOXI1Forkhead box I1. (375 aa)
PHOX2BHomeobox domain-containing protein. (178 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
NOX3NADPH oxidase 3. (568 aa)
CLRN2Clarin 2. (232 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatoz [...] (356 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
RPGRIP1LRPGRIP1 like. (1269 aa)
RESTRE1 silencing transcription factor. (930 aa)
TBX18T-box transcription factor 18. (612 aa)
STOX1Storkhead box 1. (977 aa)
PTK7Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (978 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
WHRNWhirlin. (1087 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PJVKPejvakin. (382 aa)
HESX1Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. (189 aa)
WDPCPWD repeat containing planar cell polarity effector. (603 aa)
CALB1Cerebellar calbindin. (261 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
GLI3GLI family zinc finger 3. (1575 aa)
G1SRF3_RABITPDZ domain-containing protein. (632 aa)
DVL2Dishevelled segment polarity protein 2. (783 aa)
CLDN7Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
LOC100344381Uncharacterized protein. (450 aa)
LRIG1Leucine rich repeats and immunoglobulin like domains 1. (1154 aa)
FREM2FRAS1 related extracellular matrix 2. (2846 aa)
IFT20Intraflagellar transport 20. (158 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
DLX6Distal-less homeobox 6. (164 aa)
PLPPR4Phospholipid phosphatase related 4. (762 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
TMC1Transmembrane channel-like protein. (760 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
SLC26A5Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (744 aa)
FRZBFrizzled related protein. (318 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (219 aa)
AHI1Abelson helper integration site 1. (1188 aa)
OC90Uncharacterized protein. (489 aa)
PRRX1Paired related homeobox 1. (278 aa)
PAX2Paired box 2. (448 aa)
GABRA5Gamma-aminobutyric acid type A receptor alpha5 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (463 aa)
GBX2Gastrulation brain homeobox 2. (344 aa)
ATOH1Atonal bHLH transcription factor 1. (359 aa)
CLRN1Clarin 1. (232 aa)
G1T5T5_RABITUncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (188 aa)
COL2A1Fibrillar collagen NC1 domain-containing protein. (1487 aa)
HPCAHippocalcin. (193 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (292 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Stress-activated serine/threonine-protein kinase involved in cytokine production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, CEP131, ELAVL1, HNRNPA0, HSP27/HSPB1, KRT1 [...] (379 aa)
SIX1SIX homeobox 1. (284 aa)
TBX1Uncharacterized protein. (440 aa)
TBX3Uncharacterized protein. (242 aa)
USH2AUncharacterized protein. (1543 aa)
CEP290Centrosomal protein 290. (2432 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (830 aa)
TTC8Tetratricopeptide repeat domain 8. (515 aa)
LRIG3Leucine rich repeats and immunoglobulin like domains 3. (1110 aa)
GRXCR2Glutaredoxin and cysteine rich domain containing 2. (247 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (629 aa)
LRP10LDL receptor related protein 10. (713 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
ADGRV1Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6298 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1582 aa)
PLS1Plastin 1. (630 aa)
GATA3GATA binding protein 3. (444 aa)
TSKUTsukushi, small leucine rich proteoglycan. (399 aa)
NTN1Netrin 1. (533 aa)
OTX1Orthodenticle homeobox 1. (324 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1320 aa)
HPCAL1Hippocalcin like 1. (193 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2148 aa)
POU4F3POU domain protein. (166 aa)
KCNK3Potassium channel subfamily K member. (347 aa)
TIFABUncharacterized protein. (288 aa)
ATP6V1B1Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (512 aa)
C1QTNF5C1q and TNF related 5. (243 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
G1TT13_RABITBZIP domain-containing protein. (136 aa)
HOXA1Homeobox A1 isoform a (Predicted). (337 aa)
GRXCR1Glutaredoxin and cysteine rich domain containing 1. (290 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
G1TV27_RABITUncharacterized protein. (258 aa)
OTOP1Otopetrin 1. (556 aa)
TCAPTitin-cap. (179 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
BLOC1S5Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). (187 aa)
ATG4BCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (388 aa)
TBX2T-box transcription factor 2. (662 aa)
MAFBMAF bZIP transcription factor B. (307 aa)
MYO6Myosin VI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1285 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (918 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (603 aa)
OTOL1Otolin 1. (482 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2300 aa)
BMPERBMP binding endothelial regulator. (685 aa)
ANP32BAcidic nuclear phosphoprotein 32 family member B. (321 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
MPV17Uncharacterized protein; Belongs to the peroxisomal membrane protein PXMP2/4 family. (274 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1229 aa)
TTC39CTetratricopeptide repeat domain 39C. (539 aa)
ENSOCUP00000031477Uncharacterized protein. (147 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SOBPSine oculis binding protein homolog. (583 aa)
IFT27Uncharacterized protein. (408 aa)
GRHL3Grainyhead like transcription factor 3. (619 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1110 aa)
SDC4Syndecan 4. (197 aa)
COL11A1Collagen type XI alpha 1 chain. (1857 aa)
SLC4A7Anion exchange protein. (1249 aa)
MCM2DNA helicase; Belongs to the MCM family. (902 aa)
ENSOCUP00000033288Uncharacterized protein. (125 aa)
USH1CUSH1 protein network component harmonin. (899 aa)
ENSOCUP00000033989Uncharacterized protein. (133 aa)
TRIP11Thyroid hormone receptor interactor 11. (1982 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
SLC17A8Solute carrier family 17 member 8. (610 aa)
ENSOCUP00000034581Uncharacterized protein. (151 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (469 aa)
ENSOCUP00000036498Uncharacterized protein. (1526 aa)
DLX5Distal-less homeobox 5. (313 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (1006 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
CCM2CCM2 scaffold protein. (423 aa)
ENSOCUP00000038760Uncharacterized protein. (91 aa)
CYTL1Uncharacterized protein. (195 aa)
PDZD7Uncharacterized protein. (507 aa)
HMX3H6 family homeobox 3. (340 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity). Associates with KCNE beta subunits that modulates current kinetics (By similarity). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac r [...] (695 aa)
TFAP2ATranscription factor AP-2 alpha. (732 aa)
GABRB2Gamma-aminobutyric acid type A receptor beta2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (512 aa)
DUOX2Dual oxidase 2. (1545 aa)
PROX1Prospero homeobox 1. (737 aa)
ESRRBEstrogen related receptor beta. (454 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (754 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
IFT88Intraflagellar transport 88. (827 aa)
LRRC1Leucine rich repeat containing 1. (458 aa)
CECR2CECR2 histone acetyl-lysine reader. (1315 aa)
MKS1MKS transition zone complex subunit 1. (667 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (245 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000044611Uncharacterized protein. (1515 aa)
C1QBComplement C1q B chain. (289 aa)
TRIOBPPH domain-containing protein. (904 aa)
GSDMEGasdermin E. (565 aa)
CDH23Cadherin related 23. (3330 aa)
HPNHepsin; Belongs to the peptidase S1 family. (579 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa)
ENSOCUP00000047323Fork-head domain-containing protein. (261 aa)
PAX8Paired box 8. (467 aa)
ENSOCUP00000048239Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (634 aa)
SLITRK6SLIT and NTRK like family member 6. (809 aa)
HOXA13Homeobox A13. (222 aa)
TMIETransmembrane inner ear. (170 aa)
PCDH15Protocadherin related 15. (1928 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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