STRINGSTRING
PIK3CB PIK3CB KDR KDR HLX HLX KDF1 KDF1 BAX BAX CD109 CD109 ZEB1 ZEB1 PROK2 PROK2 IFT52 IFT52 TNF TNF XBP1 XBP1 EAF2 EAF2 CLEC12B CLEC12B STAT6 STAT6 KRT2 KRT2 G1SV95_RABIT G1SV95_RABIT FGF10 FGF10 NF1 NF1 EYA1 EYA1 SDR16C5 SDR16C5 HSF4 HSF4 CCN3 CCN3 APOA1 APOA1 COL8A2 COL8A2 BMP4 BMP4 PURA PURA FSHR FSHR C12H6orf89 C12H6orf89 MTSS1 MTSS1 TP63 TP63 MEF2C MEF2C ENSOCUP00000046773 ENSOCUP00000046773 ENSOCUP00000045925 ENSOCUP00000045925 LIMS2 LIMS2 ENSOCUP00000044284 ENSOCUP00000044284 FAP FAP EFNB2 EFNB2 KLK8 KLK8 LOXL3 LOXL3 ENSOCUP00000041840 ENSOCUP00000041840 PROX1 PROX1 RB1 RB1 ENSOCUP00000040918 ENSOCUP00000040918 RPS6KA1 RPS6KA1 IFT57 IFT57 EHF EHF FGF7 FGF7 ENSOCUP00000037329 ENSOCUP00000037329 LOXL4 LOXL4 LGR5 LGR5 SCARB1 SCARB1 BMPR2 BMPR2 LOC100357982 LOC100357982 NOTCH2 NOTCH2 TGFBR1 TGFBR1 FGFR2 FGFR2 TRIM24 TRIM24 WDR77 WDR77 CD34 CD34 CYP7B1 CYP7B1 NOX5 NOX5 LOC103345451 LOC103345451 SAV1 SAV1 VSTM4 VSTM4 PPARD PPARD SMO SMO BAK1 BAK1 BMPER BMPER OVOL1 OVOL1 G1U7N5_RABIT G1U7N5_RABIT AGAP2 AGAP2 IGFBP5 IGFBP5 COL8A1 COL8A1 PHB2 PHB2 WNT16 WNT16 G1U0P1_RABIT G1U0P1_RABIT LOC100357467 LOC100357467 TBX2 TBX2 MED1 MED1 BCL2L2 BCL2L2 ID2 ID2 SIDT2 SIDT2 NKX6-1 NKX6-1 FERMT1 FERMT1 IL6 IL6 CEBPB CEBPB FSHB FSHB EPHA2 EPHA2 TNFSF11 TNFSF11 FLCN FLCN TEK TEK BMPR1A BMPR1A SHH SHH ACVR2A ACVR2A AREG AREG EREG EREG WNT2 WNT2 BTRC BTRC NKX2-8 NKX2-8 IFT80 IFT80 FGL1 FGL1 PSEN1 PSEN1 CAV1 CAV1 CAV2 CAV2 NCSTN NCSTN FGF1 FGF1 CDKN1B CDKN1B ST8SIA1 ST8SIA1 PROK1 PROK1 DRD2 DRD2 NKX2-5 NKX2-5 SERPINF1 SERPINF1 WNT5A WNT5A FGF2 FGF2 PHOX2B PHOX2B ESRP2 ESRP2 IFT74 IFT74 THAP1 THAP1 FABP7 FABP7 LIPA LIPA GPC3 GPC3 DACH1 DACH1 CALCA CALCA IGFBP4 IGFBP4 PTCH1 PTCH1 STK4 STK4 IQGAP3 IQGAP3 ITGB1BP1 ITGB1BP1 A4GNT A4GNT IRF6 IRF6 LGR4 LGR4 NKX3-1 NKX3-1 NKX2-6 NKX2-6 IFT172 IFT172 STK3 STK3 FST FST ESR1 ESR1 PDX1 PDX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
HLXH2.0 like homeobox. (682 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
CD109CD109 molecule. (1318 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
PROK2Prokineticin 2. (106 aa)
IFT52Intraflagellar transport 52. (752 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
XBP1X-box binding protein 1. (208 aa)
EAF2ELL associated factor 2. (263 aa)
CLEC12BC-type lectin domain family 12 member B. (276 aa)
STAT6Signal transducer and activator of transcription. (842 aa)
KRT2Keratin 2; Belongs to the intermediate filament family. (624 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
NF1Neurofibromin 1. (2841 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
HSF4Heat shock transcription factor 4. (491 aa)
CCN3Cellular communication network factor 3. (357 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (266 aa)
COL8A2Collagen type VIII alpha 2 chain. (705 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
PURAPurine rich element binding protein A. (460 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (703 aa)
C12H6orf89Uncharacterized protein. (311 aa)
MTSS1MTSS I-BAR domain containing 1. (892 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSOCUP00000046773Protein kinase domain-containing protein. (249 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
LIMS2LIM zinc finger domain containing 2. (439 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
FAPFibroblast activation protein alpha; Belongs to the peptidase S9B family. (766 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (332 aa)
KLK8Kallikrein related peptidase 8; Belongs to the peptidase S1 family. (285 aa)
LOXL3Lysyl oxidase like 3. (935 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
PROX1Prospero homeobox 1. (737 aa)
RB1RB transcriptional corepressor 1. (943 aa)
ENSOCUP00000040918Protein kinase domain-containing protein. (81 aa)
RPS6KA1Ribosomal protein S6 kinase. (813 aa)
IFT57Intraflagellar transport 57. (452 aa)
EHFETS homologous factor. (333 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
LOXL4Lysyl oxidase like 4. (803 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (1006 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (614 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
LOC100357982BZIP domain-containing protein. (301 aa)
NOTCH2Notch receptor 2. (2481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
TRIM24Tripartite motif containing 24. (965 aa)
WDR77WD repeat domain 77. (424 aa)
CD34CD34 molecule. (415 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (588 aa)
NOX5NADPH oxidase 5. (1003 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SAV1Salvador family WW domain containing protein 1. (392 aa)
VSTM4V-set and transmembrane domain containing 4. (399 aa)
PPARDUncharacterized protein. (420 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (787 aa)
BAK1BCL2 antagonist/killer 1. (210 aa)
BMPERBMP binding endothelial regulator. (685 aa)
OVOL1Ovo like transcriptional repressor 1. (251 aa)
G1U7N5_RABITPID domain-containing protein. (200 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (836 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
COL8A1Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). (744 aa)
PHB2Prohibitin. (299 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
G1U0P1_RABITUncharacterized protein. (209 aa)
LOC100357467Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (335 aa)
TBX2T-box transcription factor 2. (662 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
BCL2L2BCL2 like 2. (193 aa)
ID2Inhibitor of DNA binding 2. (109 aa)
SIDT2SID1 transmembrane family member 2. (853 aa)
NKX6-1NK6 homeobox 1. (369 aa)
FERMT1Fermitin family member 1. (694 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
CEBPBCCAAT enhancer binding protein beta. (353 aa)
FSHBFollitropin subunit beta; Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. (129 aa)
EPHA2EPH receptor A2. (1031 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
FLCNFolliculin. (579 aa)
TEKTEK receptor tyrosine kinase. (1025 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
AREGAmphiregulin. (275 aa)
EREGEpiregulin. (169 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (623 aa)
NKX2-8NK2 homeobox 8. (236 aa)
IFT80Intraflagellar transport 80. (777 aa)
FGL1Fibrinogen like 1. (323 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
NCSTNNicastrin. (667 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
PROK1Prokineticin 1. (105 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
NKX2-5NK2 homeobox 5. (326 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
PHOX2BHomeobox domain-containing protein. (178 aa)
ESRP2Epithelial splicing regulatory protein 2. (719 aa)
IFT74Intraflagellar transport 74. (600 aa)
THAP1THAP domain containing 1. (213 aa)
FABP7Fatty acid binding protein 7; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (157 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (409 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
DACH1Dachshund family transcription factor 1. (590 aa)
CALCACalcitonin related polypeptide alpha. (140 aa)
IGFBP4Insulin like growth factor binding protein 4. (258 aa)
PTCH1Patched 1. (1321 aa)
STK4Uncharacterized protein. (487 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1720 aa)
ITGB1BP1PID domain-containing protein. (200 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (340 aa)
IRF6Interferon regulatory factor 6. (564 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (951 aa)
NKX3-1NK3 homeobox 1. (159 aa)
NKX2-6NK2 homeobox 6. (294 aa)
IFT172Intraflagellar transport 172. (1749 aa)
STK3Serine/threonine kinase 3. (491 aa)
FSTFollistatin. (310 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (598 aa)
PDX1Pancreatic and duodenal homeobox 1. (336 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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