STRINGSTRING
IL26 IL26 SERPINF1 SERPINF1 MTSS1 MTSS1 MEF2C MEF2C CASK CASK ENSOCUP00000047273 ENSOCUP00000047273 ENSOCUP00000046773 ENSOCUP00000046773 ENSOCUP00000045925 ENSOCUP00000045925 HPN HPN RIDA RIDA LIMS2 LIMS2 DAB2 DAB2 ENSOCUP00000045056 ENSOCUP00000045056 ENSOCUP00000044284 ENSOCUP00000044284 PTPRM PTPRM AQP11 AQP11 EFNB2 EFNB2 PTPRK PTPRK ENSOCUP00000041840 ENSOCUP00000041840 RB1 RB1 ENSOCUP00000040918 ENSOCUP00000040918 IFT57 IFT57 STAT1 STAT1 CDK6 CDK6 ENSOCUP00000037329 ENSOCUP00000037329 IL12A IL12A TGFBR1 TGFBR1 FGFR2 FGFR2 MMRN2 MMRN2 NFIB NFIB TRIM24 TRIM24 WDR77 WDR77 LOC103345451 LOC103345451 SAV1 SAV1 ENSOCUP00000029917 ENSOCUP00000029917 GHRL GHRL PPARD PPARD LOC100358984 LOC100358984 MAGED1 MAGED1 G1U8R2_RABIT G1U8R2_RABIT OVOL1 OVOL1 GKN3P GKN3P SYNJ2BP SYNJ2BP PHB2 PHB2 AIMP1 AIMP1 MED1 MED1 RAP1GAP RAP1GAP NLRC3 NLRC3 ISL1 ISL1 PAX6 PAX6 FLT1 FLT1 VDR VDR ACVRL1 ACVRL1 CCL2 CCL2 CPB2 CPB2 ATP5IF1 ATP5IF1 GATA3 GATA3 FLCN FLCN PEX2 PEX2 G1TDL7_RABIT G1TDL7_RABIT B2M B2M BRCA2 BRCA2 SFRP2 SFRP2 CDC73 CDC73 IL12B IL12B TGFBR3 TGFBR3 MCC MCC NKX2-8 NKX2-8 PDCD10 PDCD10 G1T8C0_RABIT G1T8C0_RABIT IFT80 IFT80 G1T805_RABIT G1T805_RABIT CAV1 CAV1 CAV2 CAV2 WDR13 WDR13 CDKN1B CDKN1B DAB2IP DAB2IP GDF2 GDF2 CDKN2B CDKN2B SNAI2 SNAI2 ATF2 ATF2 SPARC SPARC DRD2 DRD2 TNMD TNMD BMP4 BMP4 DLL4 DLL4 GDF5 GDF5 WNT10B WNT10B VASH1 VASH1 TBC1D31 TBC1D31 PTEN PTEN NF1 NF1 G1SV95_RABIT G1SV95_RABIT NGFR NGFR DUSP10 DUSP10 ENG ENG EAF2 EAF2 TNF TNF IFT52 IFT52 ZEB1 ZEB1 CD109 CD109 KDF1 KDF1 ALOX5 ALOX5 TGFB2 TGFB2 PDX1 PDX1 KRIT1 KRIT1 STK3 STK3 IFT172 IFT172 NKX3-1 NKX3-1 IRF6 IRF6 A4GNT A4GNT ATP5F1A ATP5F1A THBS1 THBS1 ATOH8 ATOH8 SULF1 SULF1 STK4 STK4 PTCH1 PTCH1 TINF2 TINF2 ROBO1 ROBO1 GPC3 GPC3 IFT74 IFT74 PRL PRL INTU INTU XDH XDH LOC100339409 LOC100339409 PHOX2B PHOX2B WNT5A WNT5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL26Interleukin 26. (180 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
MTSS1MTSS I-BAR domain containing 1. (892 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (1000 aa)
ENSOCUP00000047273Uncharacterized protein. (231 aa)
ENSOCUP00000046773Protein kinase domain-containing protein. (249 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
HPNHepsin; Belongs to the peptidase S1 family. (579 aa)
RIDAUncharacterized protein. (137 aa)
LIMS2LIM zinc finger domain containing 2. (439 aa)
DAB2DAB adaptor protein 2. (769 aa)
ENSOCUP00000045056PDZ domain-containing protein. (145 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
PTPRMProtein tyrosine phosphatase receptor type M. (1549 aa)
AQP11Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (271 aa)
EFNB2Ephrin B2; Belongs to the ephrin family. (332 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1472 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RB1RB transcriptional corepressor 1. (943 aa)
ENSOCUP00000040918Protein kinase domain-containing protein. (81 aa)
IFT57Intraflagellar transport 57. (452 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
MMRN2Multimerin 2. (925 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (586 aa)
TRIM24Tripartite motif containing 24. (965 aa)
WDR77WD repeat domain 77. (424 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SAV1Salvador family WW domain containing protein 1. (392 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
GHRLUncharacterized protein. (234 aa)
PPARDUncharacterized protein. (420 aa)
LOC100358984Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (857 aa)
MAGED1MAGE family member D1. (823 aa)
G1U8R2_RABITUncharacterized protein. (137 aa)
OVOL1Ovo like transcriptional repressor 1. (251 aa)
GKN3PGastrokine 3, pseudogene. (188 aa)
SYNJ2BPPDZ domain-containing protein. (145 aa)
PHB2Prohibitin. (299 aa)
AIMP1Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (334 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
RAP1GAPRAP1 GTPase activating protein. (657 aa)
NLRC3NLR family CARD domain containing 3. (992 aa)
ISL1ISL LIM homeobox 1. (349 aa)
PAX6Uncharacterized protein. (436 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1479 aa)
VDRVitamin D receptor. (368 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
CPB2Carboxypeptidase B2. (424 aa)
ATP5IF1Uncharacterized protein. (148 aa)
GATA3GATA binding protein 3. (444 aa)
FLCNFolliculin. (579 aa)
PEX2Peroxisomal biogenesis factor 2. (305 aa)
G1TDL7_RABITUncharacterized protein. (125 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (120 aa)
BRCA2BRCA2 DNA repair associated. (3412 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
CDC73Cell division cycle 73. (728 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
MCCMCC regulator of WNT signaling pathway. (1105 aa)
NKX2-8NK2 homeobox 8. (236 aa)
PDCD10Programmed cell death 10. (212 aa)
G1T8C0_RABITUncharacterized protein. (311 aa)
IFT80Intraflagellar transport 80. (777 aa)
G1T805_RABITSEA domain-containing protein. (248 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CAV2Caveolin-2; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity); Belongs to the caveolin family. (162 aa)
WDR13WD repeat domain 13. (478 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
DAB2IPDAB2 interacting protein. (1178 aa)
GDF2Growth differentiation factor 2. (434 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
SNAI2Uncharacterized protein. (268 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (498 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (315 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
TNMDMyodulin. (317 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
GDF5Growth differentiation factor 5 preproprotein (Predicted). (500 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
VASH1Vasohibin 1. (369 aa)
TBC1D31TBC1 domain family member 31. (1067 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
NF1Neurofibromin 1. (2841 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
NGFRNerve growth factor receptor. (407 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
ENGEndoglin. (758 aa)
EAF2ELL associated factor 2. (263 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
IFT52Intraflagellar transport 52. (752 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1080 aa)
CD109CD109 molecule. (1318 aa)
KDF1Keratinocyte differentiation factor 1. (398 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PDX1Pancreatic and duodenal homeobox 1. (336 aa)
KRIT1Uncharacterized protein. (736 aa)
STK3Serine/threonine kinase 3. (491 aa)
IFT172Intraflagellar transport 172. (1749 aa)
NKX3-1NK3 homeobox 1. (159 aa)
IRF6Interferon regulatory factor 6. (564 aa)
A4GNTAlpha-1,4-N-acetylglucosaminyltransferase. (340 aa)
ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
THBS1Thrombospondin 1. (1171 aa)
ATOH8Atonal bHLH transcription factor 8. (369 aa)
SULF1Sulfatase 1. (846 aa)
STK4Uncharacterized protein. (487 aa)
PTCH1Patched 1. (1321 aa)
TINF2TERF1 interacting nuclear factor 2. (356 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
IFT74Intraflagellar transport 74. (600 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (262 aa)
INTUInturned planar cell polarity protein. (944 aa)
XDHUncharacterized protein. (1333 aa)
LOC100339409Uncharacterized protein. (106 aa)
PHOX2BHomeobox domain-containing protein. (178 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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