STRINGSTRING
ATP13A2 ATP13A2 ENSOCUP00000033836 ENSOCUP00000033836 GPLD1 GPLD1 GHRL GHRL PPARD PPARD EXOC1 EXOC1 U3KNC9_RABIT U3KNC9_RABIT ARF6 ARF6 LRRC8A LRRC8A TLR4 TLR4 F2RL1 F2RL1 ADCY8 ADCY8 PCK2 PCK2 PTPN23 PTPN23 G1SJA2_RABIT G1SJA2_RABIT PSMD9 PSMD9 GIP GIP TMED10 TMED10 PDX1 PDX1 CD2AP CD2AP TGFB2 TGFB2 NLGN2 NLGN2 PLA2G6 PLA2G6 KCNN4 KCNN4 TRH TRH NR0B2 NR0B2 PPID PPID ANKRD1 ANKRD1 NR1H4 NR1H4 SEC24A SEC24A G1SV95_RABIT G1SV95_RABIT SLC30A8 SLC30A8 ADORA2A ADORA2A IL1A IL1A P2RX7 P2RX7 GLUL GLUL PARD6A PARD6A FGG FGG LOC103345451 LOC103345451 APBB3 APBB3 VPS35 VPS35 C2CD2L C2CD2L SYTL4 SYTL4 FGB FGB TM7SF3 TM7SF3 FGA FGA TGFB3 TGFB3 GOLPH3 GOLPH3 GIPR GIPR PCSK1 PCSK1 IER3IP1 IER3IP1 RFX6 RFX6 AACS AACS UCN3 UCN3 PRKCE PRKCE GPR68 GPR68 PFKFB2 PFKFB2 NNAT NNAT MCU MCU SRI SRI EXPH5 EXPH5 JAK2 JAK2 VEGFC VEGFC GPER1 GPER1 CAPN10 CAPN10 HMMR HMMR GCG GCG PPP3CB PPP3CB ISL1 ISL1 C1QTNF3 C1QTNF3 IGF1 IGF1 DOC2B DOC2B P2RY8 P2RY8 VSNL1 VSNL1 HCAR2 HCAR2 BLK BLK MYRIP MYRIP GCK GCK TCF7L2 TCF7L2 WLS WLS ENSOCUP00000036170 ENSOCUP00000036170 ENSOCUP00000037329 ENSOCUP00000037329 FRMD4A FRMD4A ENSOCUP00000038143 ENSOCUP00000038143 MYH10 MYH10 MLPH MLPH MYO18A MYO18A ENSOCUP00000040784 ENSOCUP00000040784 HIF1A HIF1A STX4 STX4 LOC100348748 LOC100348748 DNM1L DNM1L ENSOCUP00000041840 ENSOCUP00000041840 APBB1 APBB1 ENSOCUP00000042436 ENSOCUP00000042436 MYOM1 MYOM1 GOLPH3L GOLPH3L ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 TUNAR TUNAR ACSL4 ACSL4 ABAT ABAT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (738 aa)
ENSOCUP00000033836Uncharacterized protein. (99 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (852 aa)
GHRLUncharacterized protein. (234 aa)
PPARDUncharacterized protein. (420 aa)
EXOC1Exocyst complex component 1. (919 aa)
U3KNC9_RABITUncharacterized protein. (382 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (769 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
PTPN23Protein tyrosine phosphatase non-receptor type 23. (1630 aa)
G1SJA2_RABITAnoctamin. (745 aa)
PSMD9PDZ domain-containing protein. (283 aa)
GIPGastric inhibitory polypeptide. (153 aa)
TMED10Transmembrane emp24 domain-containing protein 10; Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft [...] (219 aa)
PDX1Pancreatic and duodenal homeobox 1. (336 aa)
CD2APUncharacterized protein. (636 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NLGN2Neuroligin 2. (823 aa)
PLA2G6Uncharacterized protein. (485 aa)
KCNN4Potassium calcium-activated channel subfamily N member 4. (404 aa)
TRHThyrotropin releasing hormone. (280 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (260 aa)
PPIDPeptidylprolyl isomerase D. (369 aa)
ANKRD1Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (319 aa)
NR1H4Uncharacterized protein. (486 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1091 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
GLULGlutamine synthetase. (373 aa)
PARD6APar-6 family cell polarity regulator alpha. (346 aa)
FGGFibrinogen gamma chain. (450 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
APBB3Amyloid beta precursor protein binding family B member 3. (446 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
C2CD2LC2CD2 like. (707 aa)
SYTL4Synaptotagmin like 4. (671 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (492 aa)
TM7SF3Transmembrane 7 superfamily member 3. (602 aa)
FGAFibrinogen alpha chain. (813 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
GOLPH3Golgi phosphoprotein 3. (298 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (468 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1. (751 aa)
IER3IP1Uncharacterized protein. (82 aa)
RFX6Regulatory factor X6. (928 aa)
AACSAcetoacetyl-CoA synthetase. (793 aa)
UCN3Urocortin 3. (167 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (519 aa)
NNATUncharacterized protein. (125 aa)
MCUMitochondrial calcium uniporter. (350 aa)
SRIUncharacterized protein. (422 aa)
EXPH5Exophilin 5. (1797 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (660 aa)
HMMRHyaluronan mediated motility receptor. (709 aa)
GCGGlucagon; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis (By similarity). (180 aa)
PPP3CBSerine/threonine-protein phosphatase. (518 aa)
ISL1ISL LIM homeobox 1. (349 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
DOC2BUncharacterized protein. (492 aa)
P2RY8P2Y receptor family member 8; Belongs to the G-protein coupled receptor 1 family. (382 aa)
VSNL1Visinin like 1. (191 aa)
HCAR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (363 aa)
BLKTyrosine-protein kinase. (525 aa)
MYRIPMyosin VIIA and Rab interacting protein. (895 aa)
GCKPhosphotransferase. (246 aa)
TCF7L2Transcription factor 7 like 2. (605 aa)
WLSWnt ligand secretion mediator. (543 aa)
ENSOCUP00000036170SH3 domain-containing protein. (389 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
FRMD4AFERM domain containing 4A. (1064 aa)
ENSOCUP00000038143Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
MLPHMelanophilin. (565 aa)
MYO18AMyosin XVIIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2435 aa)
ENSOCUP00000040784Uncharacterized protein. (227 aa)
HIF1AUncharacterized protein. (851 aa)
STX4t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (298 aa)
LOC100348748IGv domain-containing protein. (604 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (934 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (777 aa)
ENSOCUP00000042436GOLD domain-containing protein; Belongs to the EMP24/GP25L family. (114 aa)
MYOM1Myomesin 1. (1776 aa)
GOLPH3LGolgi phosphoprotein 3 like. (285 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (45 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (711 aa)
ABAT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (549 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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