STRINGSTRING
NR1D1 NR1D1 PPARD PPARD GHRL GHRL RORA RORA ENSOCUP00000032553 ENSOCUP00000032553 CYLD CYLD IL20RB IL20RB NPY5R NPY5R ENSOCUP00000039487 ENSOCUP00000039487 ADORA1 ADORA1 APOA1 APOA1 CCN3 CCN3 FFAR4 FFAR4 VPS35 VPS35 LOC100340374 LOC100340374 CDH5 CDH5 FOXP3 FOXP3 C5orf30 C5orf30 CD200R1 CD200R1 TNFRSF1A TNFRSF1A ACOD1 ACOD1 LOC100338113 LOC100338113 GRN GRN MKRN2 MKRN2 NR1D2 NR1D2 PROC PROC LOC100348748 LOC100348748 RB1 RB1 PTPN2 PTPN2 SYT11 SYT11 FNDC4 FNDC4 ADA ADA IL2 IL2 NLRP12 NLRP12 PPARA PPARA ADORA2A ADORA2A PLA2G5 PLA2G5 DUSP10 DUSP10 CX3CL1 CX3CL1 PGLYRP1 PGLYRP1 GHSR GHSR NR1H4 NR1H4 LRFN5 LRFN5 TYRO3 TYRO3 G1SPA3_RABIT G1SPA3_RABIT ALOX5 ALOX5 MEFV MEFV TNFAIP8L2 TNFAIP8L2 MMP26 MMP26 ZFP36 ZFP36 TNFAIP3 TNFAIP3 NR1H3 NR1H3 FOXF1 FOXF1 PTGER4 PTGER4 PLA2G10 PLA2G10 PSMA1 PSMA1 TAFA3 TAFA3 IL13 IL13 G1SCK7_RABIT G1SCK7_RABIT SERPINF1 SERPINF1 PBK PBK GPR17 GPR17 OTULIN OTULIN CYP19A1 CYP19A1 SMPDL3B SMPDL3B NOD2 NOD2 TNFAIP6 TNFAIP6 CALCRL CALCRL MVK MVK TNFRSF1B TNFRSF1B METRNL METRNL ENPP3 ENPP3 LPCAT3 LPCAT3 ASH1L ASH1L RABGEF1 RABGEF1 PSMB4 PSMB4 IL12B IL12B GIT1 GIT1 GATA3 GATA3 GPER1 GPER1 SOD1 SOD1 SELENOS SELENOS CST7 CST7 IL10 IL10 CXCL17 CXCL17 ISL1 ISL1 NLRC3 NLRC3 INS INS ADIPOQ ADIPOQ GPS2 GPS2 C1QTNF3 C1QTNF3 PLA2G10-2 PLA2G10-2 IGF1 IGF1 NLRX1 NLRX1 IL22RA2 IL22RA2 MFHAS1 MFHAS1 NFKB1 NFKB1 IL4 IL4 SLAMF8 SLAMF8 NT5E NT5E NDFIP1 NDFIP1 LOC100349682 LOC100349682 BCR BCR SMAD3 SMAD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NR1D1Nuclear receptor subfamily 1 group D member 1. (658 aa)
PPARDUncharacterized protein. (420 aa)
GHRLUncharacterized protein. (234 aa)
RORARAR related orphan receptor A. (512 aa)
ENSOCUP00000032553PROTEASOME_ALPHA_1 domain-containing protein. (168 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
IL20RBInterleukin 20 receptor subunit beta. (307 aa)
NPY5RNeuropeptide Y receptor Y5. (455 aa)
ENSOCUP00000039487Pyrin domain-containing protein. (105 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (328 aa)
APOA1Truncated apolipoprotein A-I; Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. (266 aa)
CCN3Cellular communication network factor 3. (357 aa)
FFAR4Free fatty acid receptor 4. (361 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
LOC100340374Uncharacterized protein. (685 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (974 aa)
FOXP3Forkhead box P3. (455 aa)
C5orf30Chromosome 5 open reading frame 30. (242 aa)
CD200R1IG domain-containing protein. (335 aa)
TNFRSF1ATNF receptor superfamily member 1A. (472 aa)
ACOD1Aconitate decarboxylase 1. (499 aa)
LOC100338113Uncharacterized protein. (282 aa)
GRNGranulin precursor. (626 aa)
MKRN2Makorin ring finger protein 2. (424 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (612 aa)
PROCVitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. (498 aa)
LOC100348748IGv domain-containing protein. (604 aa)
RB1RB transcriptional corepressor 1. (943 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (415 aa)
SYT11Synaptotagmin 11. (440 aa)
FNDC4Fibronectin type III domain containing 4. (260 aa)
ADAAdenosine deaminase. (363 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
NLRP12NLR family pyrin domain containing 12. (1060 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
PLA2G5Phospholipase A(2). (246 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
PGLYRP1Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (197 aa)
GHSRGrowth hormone secretagogue receptor type 1; Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK- 0677, adenosine) (By similarity). (366 aa)
NR1H4Uncharacterized protein. (486 aa)
LRFN5Leucine rich repeat and fibronectin type III domain containing 5. (718 aa)
TYRO3TYRO3 protein tyrosine kinase. (860 aa)
G1SPA3_RABITUncharacterized protein. (226 aa)
ALOX5Arachidonate 5-lipoxygenase. (674 aa)
MEFVMEFV innate immuity regulator, pyrin. (861 aa)
TNFAIP8L2Tumor necrosis factor alpha-induced protein 8-like protein 2; Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity); Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. (184 aa)
MMP26Matrix metallopeptidase 26. (265 aa)
ZFP36ZFP36 ring finger protein. (338 aa)
TNFAIP3TNF alpha induced protein 3. (787 aa)
NR1H3Liver X receptor alpha. (447 aa)
FOXF1Forkhead box F1. (433 aa)
PTGER4Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. (488 aa)
PLA2G10Phospholipase A(2). (163 aa)
PSMA1Proteasome subunit alpha type. (263 aa)
TAFA3Uncharacterized protein. (133 aa)
IL13Interleukin 13. (138 aa)
G1SCK7_RABITUncharacterized protein; Belongs to the cytochrome P450 family. (765 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
PBKPDZ binding kinase. (322 aa)
GPR17G protein-coupled receptor 17; Belongs to the G-protein coupled receptor 1 family. (419 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (347 aa)
CYP19A1Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (503 aa)
SMPDL3BSphingomyelin phosphodiesterase acid like 3B. (487 aa)
NOD2Nucleotide oligomerization domain 2 protein. (1013 aa)
TNFAIP6Tumor necrosis factor-inducible gene 6 protein; Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. (276 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (465 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
TNFRSF1BTNF receptor superfamily member 1B. (425 aa)
METRNLMeteorin like, glial cell differentiation regulator. (307 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (940 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (486 aa)
ASH1LASH1 like histone lysine methyltransferase. (2966 aa)
RABGEF1Uncharacterized protein. (492 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
GIT1GIT ArfGAP 1. (753 aa)
GATA3GATA binding protein 3. (444 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (153 aa)
SELENOSUncharacterized protein. (317 aa)
CST7Cystatin F. (164 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
CXCL17C-X-C motif chemokine ligand 17. (122 aa)
ISL1ISL LIM homeobox 1. (349 aa)
NLRC3NLR family CARD domain containing 3. (992 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
ADIPOQC1q domain-containing protein. (244 aa)
GPS2G protein pathway suppressor 2. (327 aa)
C1QTNF3C1q domain-containing protein. (319 aa)
PLA2G10-2Phospholipase A(2). (152 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
NLRX1NLR family member X1. (803 aa)
IL22RA2Interleukin 22 receptor subunit alpha 2. (231 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
NFKB1Nuclear factor kappa B subunit 1. (968 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
SLAMF8SLAM family member 8. (312 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (591 aa)
NDFIP1Nedd4 family interacting protein 1. (226 aa)
LOC100349682Ig-like domain-containing protein. (304 aa)
BCRBCR activator of RhoGEF and GTPase. (1192 aa)
SMAD3SMAD family member 3. (230 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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