STRINGSTRING
LAYN LAYN WNT5A WNT5A KIAA0319 KIAA0319 SYNGAP1 SYNGAP1 ARHGAP4 ARHGAP4 BCL11A BCL11A ZFYVE27 ZFYVE27 PLXNB1 PLXNB1 LRP4 LRP4 UST UST SEMA3B SEMA3B ROBO1 ROBO1 SEMA6C SEMA6C SEMA4G SEMA4G SRF SRF G1SJF5_RABIT G1SJF5_RABIT SEMA4C SEMA4C PLXNA2 PLXNA2 PLXNA1 PLXNA1 SLIT1 SLIT1 SEMA5A SEMA5A ROBO2 ROBO2 EFNA1 EFNA1 NRP1 NRP1 SEMA4F SEMA4F MAP3K13 MAP3K13 TRPV2 TRPV2 DRAXIN DRAXIN SEMA5B SEMA5B XK XK CRABP2 CRABP2 THY1 THY1 SEMA3G SEMA3G PTEN PTEN IST1 IST1 RND2 RND2 NTRK2 NTRK2 RUFY3 RUFY3 DISC1 DISC1 CYFIP1 CYFIP1 SEMA3F SEMA3F SEMA3A SEMA3A SEMA3D SEMA3D RTN4 RTN4 G1T2I9_RABIT G1T2I9_RABIT TIAM2 TIAM2 POU4F2 POU4F2 EPHB3 EPHB3 SEMA4D SEMA4D SLITRK1 SLITRK1 PLXND1 PLXND1 PSEN1 PSEN1 ADNP ADNP SEMA4B SEMA4B IFRD1 IFRD1 CNTN2 CNTN2 NIN NIN RNF6 RNF6 EFNA5 EFNA5 G1TBJ9_RABIT G1TBJ9_RABIT PLXNB3 PLXNB3 TIAM1 TIAM1 PLXNC1 PLXNC1 ARHGAP35 ARHGAP35 SPART SPART TNR TNR MEGF8 MEGF8 NTN1 NTN1 NEFL NEFL L1CAM L1CAM LOC103348513 LOC103348513 RYK RYK DBN1 DBN1 TWF2 TWF2 MAG MAG LPAR3 LPAR3 AMIGO2 AMIGO2 LIMK1 LIMK1 CDK5 CDK5 AMIGO1 AMIGO1 FSTL4 FSTL4 ULK1 ULK1 G1U9D6_RABIT G1U9D6_RABIT GOLGA4 GOLGA4 SHOX2 SHOX2 EFNB3 EFNB3 SHTN1 SHTN1 BRSK1 BRSK1 CDKL3 CDKL3 PLXNA4 PLXNA4 SLIT2 SLIT2 MAPT MAPT SEMA7A SEMA7A MAP2 MAP2 BRAF BRAF DIP2B DIP2B WNT3 WNT3 GSK3B GSK3B CDKL5 CDKL5 SIPA1L1 SIPA1L1 SEMA6A SEMA6A RET RET PAK1 PAK1 BDNF BDNF BMPR2 BMPR2 SEMA4A SEMA4A KIF13B KIF13B ENSOCUP00000040871 ENSOCUP00000040871 PLXNA3 PLXNA3 DIXDC1 DIXDC1 CHN1 CHN1 DAB1 DAB1 KEL KEL MAP1B MAP1B UBE2D4 UBE2D4 FGF13 FGF13 PAK3 PAK3 WNT3A WNT3A ULK2 ULK2 TRIM46 TRIM46
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LAYNLayilin. (383 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
KIAA0319KIAA0319. (1139 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1337 aa)
ARHGAP4Rho GTPase activating protein 4. (924 aa)
BCL11ABAF chromatin remodeling complex subunit BCL11A. (975 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (416 aa)
PLXNB1Plexin B1. (2118 aa)
LRP4LDL receptor related protein 4. (1899 aa)
USTUronyl 2-sulfotransferase. (310 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (757 aa)
ROBO1Roundabout guidance receptor 1. (1651 aa)
SEMA6CSema domain-containing protein; Belongs to the semaphorin family. (948 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (843 aa)
SRFSerum response factor. (685 aa)
G1SJF5_RABITUncharacterized protein. (530 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (832 aa)
PLXNA2Plexin A2. (1897 aa)
PLXNA1Plexin A1. (1772 aa)
SLIT1Slit guidance ligand 1. (1452 aa)
SEMA5ASemaphorin 5A. (978 aa)
ROBO2Roundabout guidance receptor 2. (1438 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (950 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (721 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (1009 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2. (817 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (337 aa)
SEMA5BSemaphorin 5B. (1077 aa)
XKXK-related protein. (444 aa)
CRABP2Cellular retinoic acid binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
THY1Thy-1 cell surface antigen. (161 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (777 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
IST1IST1 factor associated with ESCRT-III. (372 aa)
RND2Rho family GTPase 2. (291 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
RUFY3RUN and FYVE domain containing 3. (617 aa)
DISC1DISC1 scaffold protein. (859 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1272 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (784 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (770 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
RTN4Reticulon. (1110 aa)
G1T2I9_RABITC-type lectin domain-containing protein. (510 aa)
TIAM2DH domain-containing protein. (609 aa)
POU4F2POU domain protein. (392 aa)
EPHB3EPH receptor B3. (1075 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (864 aa)
SLITRK1SLIT and NTRK like family member 1. (706 aa)
PLXND1Plexin D1. (1886 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
ADNPActivity dependent neuroprotector homeobox. (1104 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (832 aa)
IFRD1Interferon related developmental regulator 1. (451 aa)
CNTN2Contactin 2. (1040 aa)
NINNinein. (2216 aa)
RNF6Ring finger protein 6. (683 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
G1TBJ9_RABITUncharacterized protein. (276 aa)
PLXNB3Plexin B3. (1844 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1592 aa)
PLXNC1Plexin_cytopl domain-containing protein. (428 aa)
ARHGAP35Rho GTPase activating protein 35. (1415 aa)
SPARTSpartin. (679 aa)
TNRTenascin R. (1359 aa)
MEGF8Uncharacterized protein. (439 aa)
NTN1Netrin 1. (533 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (548 aa)
L1CAMUncharacterized protein. (1256 aa)
LOC103348513Uncharacterized protein. (322 aa)
RYKReceptor like tyrosine kinase. (553 aa)
DBN1Drebrin 1. (623 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
MAGUncharacterized protein. (58 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (401 aa)
AMIGO2Ig-like domain-containing protein. (810 aa)
LIMK1LIM domain kinase 1. (645 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
FSTL4Follistatin like 4. (807 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1001 aa)
G1U9D6_RABITUncharacterized protein. (105 aa)
GOLGA4Golgin A4. (2199 aa)
SHOX2Short stature homeobox 2. (211 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (486 aa)
SHTN1Shootin 1. (613 aa)
BRSK1BR serine/threonine kinase 1. (627 aa)
CDKL3Cyclin dependent kinase like 3. (673 aa)
PLXNA4Plexin A4. (1912 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
MAPTMicrotubule-associated protein. (840 aa)
SEMA7ASema domain-containing protein; Belongs to the semaphorin family. (408 aa)
MAP2Microtubule-associated protein. (1921 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (767 aa)
DIP2BDisco interacting protein 2 homolog B. (1621 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
CDKL5Cyclin dependent kinase like 5. (1001 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1789 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1038 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
PAK1Non-specific serine/threonine protein kinase. (585 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (265 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (977 aa)
KIF13BKinesin family member 13B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1889 aa)
ENSOCUP00000040871Uncharacterized protein. (164 aa)
PLXNA3Sema domain-containing protein. (1995 aa)
DIXDC1DIX domain containing 1. (620 aa)
CHN1Chimerin 1. (531 aa)
DAB1DAB adaptor protein 1. (593 aa)
KELKell metallo-endopeptidase (Kell blood group). (732 aa)
MAP1BMicrotubule associated protein 1B. (2355 aa)
UBE2D4Uncharacterized protein; Belongs to the ubiquitin-conjugating enzyme family. (712 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (271 aa)
PAK3Non-specific serine/threonine protein kinase. (652 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (400 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1066 aa)
TRIM46Tripartite motif containing 46. (907 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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