STRINGSTRING
SNAP47 SNAP47 PINK1 PINK1 STAU1 STAU1 NR2E1 NR2E1 LGMN LGMN NLGN2 NLGN2 PRRT1 PRRT1 GIP GIP SERPINE2 SERPINE2 CACNG3 CACNG3 GRIK2 GRIK2 ADCY8 ADCY8 NRGN NRGN CHRNA7 CHRNA7 SLC24A2 SLC24A2 TACR1 TACR1 ZDHHC3 ZDHHC3 ENSOCUP00000037776 ENSOCUP00000037776 RGS14 RGS14 DRD2 DRD2 ADORA1 ADORA1 NTRK1 NTRK1 APP APP STX1B STX1B VAMP2 VAMP2 NPTN NPTN NTRK2 NTRK2 LAMA2 LAMA2 RELN RELN RAPSN RAPSN GLUL GLUL NALCN NALCN PTEN PTEN ADORA2A ADORA2A LGI1 LGI1 KMO KMO ITPR3 ITPR3 CRHR2 CRHR2 KISS1 KISS1 CACNB2 CACNB2 STX4 STX4 DTNBP1 DTNBP1 ENSOCUP00000044159 ENSOCUP00000044159 NLGN1 NLGN1 SLC8A3 SLC8A3 ENSOCUP00000046066 ENSOCUP00000046066 ENSOCUP00000046526 ENSOCUP00000046526 DLG4 DLG4 IGSF11 IGSF11 RAB3GAP1 RAB3GAP1 ENSOCUP00000048545 ENSOCUP00000048545 MECP2 MECP2 SHANK2 SHANK2 RIMS2 RIMS2 PRKCE PRKCE RIMS3 RIMS3 CACNG4 CACNG4 CLSTN3 CLSTN3 FMR1 FMR1 GRIN2B GRIN2B SQSTM1 SQSTM1 TSHZ3 TSHZ3 SLC4A8 SLC4A8 ROR2 ROR2 STX1A STX1A FLOT1 FLOT1 KIF5B KIF5B KCTD13 KCTD13 TNR TNR G1TET4_RABIT G1TET4_RABIT CCL2 CCL2 SLC24A1 SLC24A1 GPER1 GPER1 AGER AGER STXBP1 STXBP1 PTK2B PTK2B GRIN2D GRIN2D RETN RETN GRIN2C GRIN2C CACNG2 CACNG2 NLGN3 NLGN3 AKAP5 AKAP5 SLC1A3 SLC1A3 LRRTM2 LRRTM2 CDK5 CDK5 SYT1 SYT1 CACNG7 CACNG7 LRRTM1 LRRTM1 CLSTN2 CLSTN2 SYT12 SYT12 CACNG5 CACNG5 NFATC4 NFATC4 LOC100359182 LOC100359182 BRAF BRAF ENSOCUP00000031759 ENSOCUP00000031759 CA7 CA7 ENSOCUP00000032183 ENSOCUP00000032183 CLSTN1 CLSTN1 SNAP25 SNAP25 ZDHHC2 ZDHHC2 GFAP GFAP NPS NPS GRIN2A GRIN2A STX3 STX3 PLK2 PLK2 TNF TNF EIF2AK4 EIF2AK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SNAP47Synaptosome associated protein 47. (420 aa)
PINK1PTEN induced kinase 1. (569 aa)
STAU1Staufen double-stranded RNA binding protein 1. (577 aa)
NR2E1Uncharacterized protein. (475 aa)
LGMNLegumain. (435 aa)
NLGN2Neuroligin 2. (823 aa)
PRRT1Uncharacterized protein. (83 aa)
GIPGastric inhibitory polypeptide. (153 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
CACNG3Calcium voltage-gated channel auxiliary subunit gamma 3. (314 aa)
GRIK2Glutamate ionotropic receptor kainate type subunit 2. (908 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
NRGNNeurogranin. (78 aa)
CHRNA7Uncharacterized protein. (513 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (665 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
ZDHHC3Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (400 aa)
ENSOCUP00000037776Uncharacterized protein. (514 aa)
RGS14Regulator of G protein signaling 14. (552 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ADORA1Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase; Belongs to the G-protein coupled receptor 1 family. (328 aa)
NTRK1Tyrosine-protein kinase receptor. (823 aa)
APPGamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (196 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (226 aa)
NPTNNeuroplastin. (367 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
LAMA2Laminin subunit alpha 2. (3126 aa)
RELNUncharacterized protein. (1813 aa)
RAPSNReceptor associated protein of the synapse. (412 aa)
GLULGlutamine synthetase. (373 aa)
NALCNSodium leak channel, non-selective. (1796 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (409 aa)
LGI1Leucine rich glioma inactivated 1. (557 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (485 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (2616 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (431 aa)
KISS1Uncharacterized protein. (244 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2; The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. (632 aa)
STX4t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (298 aa)
DTNBP1Uncharacterized protein. (336 aa)
ENSOCUP00000044159Uncharacterized protein. (553 aa)
NLGN1Neuroligin 1. (823 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (958 aa)
ENSOCUP00000046066EGF-like domain-containing protein. (561 aa)
ENSOCUP00000046526Reelin domain-containing protein. (274 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
IGSF11Immunoglobulin superfamily member 11. (446 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
ENSOCUP00000048545Uncharacterized protein. (222 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (485 aa)
SHANK2SH3 and multiple ankyrin repeat domains 2. (1891 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1620 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (307 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (341 aa)
CLSTN3Calsyntenin 3. (958 aa)
FMR1Fragile X mental retardation 1. (632 aa)
GRIN2BGlutamate ionotropic receptor NMDA type subunit 2B. (1484 aa)
SQSTM1Sequestosome 1. (518 aa)
TSHZ3Teashirt zinc finger homeobox 3. (1077 aa)
SLC4A8Anion exchange protein. (1027 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (315 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (921 aa)
KCTD13Potassium channel tetramerization domain containing 13. (329 aa)
TNRTenascin R. (1359 aa)
G1TET4_RABITUncharacterized protein. (1011 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
SLC24A1Na_Ca_ex domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (470 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (361 aa)
AGERAdvanced glycosylation end-product specific receptor. (401 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
GRIN2DGlutamate ionotropic receptor NMDA type subunit 2D. (888 aa)
RETNResistin. (112 aa)
GRIN2CUncharacterized protein; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (671 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (256 aa)
NLGN3Neuroligin 3. (828 aa)
AKAP5A-kinase anchoring protein 5. (403 aa)
SLC1A3Amino acid transporter. (542 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SYT1Synaptotagmin 1. (447 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (274 aa)
LRRTM1Leucine rich repeat transmembrane neuronal 1. (574 aa)
CLSTN2Calsyntenin 2. (957 aa)
SYT12Synaptotagmin 12. (488 aa)
CACNG5Calcium voltage-gated channel auxiliary subunit gamma 5. (275 aa)
NFATC4Nuclear factor of activated T cells 4. (933 aa)
LOC100359182Amino acid transporter. (665 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (767 aa)
ENSOCUP00000031759Guanylate cyclase domain-containing protein. (312 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (324 aa)
ENSOCUP00000032183Uncharacterized protein. (349 aa)
CLSTN1Calsyntenin 1. (951 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (254 aa)
ZDHHC2Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (320 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
NPSUncharacterized protein. (89 aa)
GRIN2AGlutamate ionotropic receptor NMDA type subunit 2A. (1087 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (264 aa)
PLK2Serine/threonine-protein kinase PLK. (666 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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