(53 nodes) Defense response to Gram-negative bacterium network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CAMP	Antimicrobial protein CAP18; CAP18 binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Has antibiotic activity. (171 aa)
	G1TVR0_RABIT	Uncharacterized protein. (254 aa)
	DEFB1	Uncharacterized protein. (101 aa)
	G1TY93_RABIT	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (223 aa)
	TSLP	Uncharacterized protein. (149 aa)
	G1U076_RABIT	Uncharacterized protein. (193 aa)
	BPI	Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (486 aa)
	MPEG1	Macrophage expressed 1. (717 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (362 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
	ROMO1	Uncharacterized protein RA_r333_jsm669B4f. (79 aa)
	LOC103348210	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (113 aa)
	RPL30	Ribosomal protein L30. (115 aa)
	DEFB128	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (95 aa)
	LTF	Lactotransferrin; Belongs to the transferrin family. (708 aa)
	LOC100349504	Uncharacterized protein. (290 aa)
	G1TM30_RABIT	Uncharacterized protein. (246 aa)
	PRKD1	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
	CHGA	Uncharacterized protein. (289 aa)
	DROSHA	Drosha ribonuclease III. (1365 aa)
	LOC100356315	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa)
	CTSG	Cathepsin G. (250 aa)
	GSDMD	Gasdermin D. (471 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	DEFB127	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (98 aa)
	IL17A	Interleukin 17A. (153 aa)
	IL17F	Interleukin 17F. (163 aa)
	PYCARD	PYD and CARD domain containing. (196 aa)
	TUSC2	Uncharacterized protein. (112 aa)
	DEFB136	Defensin beta 136. (78 aa)
	IL22RA1	Interleukin 22 receptor subunit alpha 1. (679 aa)
	OPTN	Optineurin. (521 aa)
	IL23A	Interleukin 23 subunit alpha. (191 aa)
	UMOD	Uromodulin. (794 aa)
	ENSOCUP00000036156	Ribosomal_L7Ae domain-containing protein. (88 aa)
	ENSOCUP00000038340	DEFENSIN domain-containing protein. (100 aa)
	GHRHR	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa)
	ENSOCUP00000041505	Ribosomal_L7Ae domain-containing protein. (93 aa)
	NLRP10	NLR family pyrin domain containing 10. (724 aa)
	LOC100348748	IGv domain-containing protein. (604 aa)
	DEFB114	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa)
	Dmbt1	Deleted in malignant brain tumors 1 protein; May play roles in mucosal defense system and cellular immune defense. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. Required for terminal differentiation of columnar epithe [...] (1482 aa)
	LOC103346080	Defensin_propep domain-containing protein. (121 aa)
	TLR9	TIR domain-containing protein. (1027 aa)
	ENSOCUP00000048609	Ribosomal_L7Ae domain-containing protein. (211 aa)
	LBP	Lipopolysaccharide-binding protein; Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide. Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (496 aa)
	LOC100009135	DEFENSIN domain-containing protein. (148 aa)
	RNASE6	Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (154 aa)
	ENSOCUP00000032880	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (183 aa)
	DEFB119	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (87 aa)
	SLC11A1	Uncharacterized protein. (552 aa)
	ENSOCUP00000027867	Uncharacterized protein. (167 aa)
	G1U7B0_RABIT	UPAR/Ly6 domain-containing protein. (159 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BPI	CTSG	ENSOCUP00000011699	ENSOCUP00000001158	Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Cathepsin G.	0.778
BPI	LOC100356315	ENSOCUP00000011699	ENSOCUP00000000566	Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family.	0.496
BPI	LTF	ENSOCUP00000011699	ENSOCUP00000015815	Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	Lactotransferrin; Belongs to the transferrin family.	0.466
BPI	TLR4	ENSOCUP00000011699	ENSOCUP00000001909	Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.623
CAMP	G1TM30_RABIT	ENSOCUP00000013325	ENSOCUP00000018036	Antimicrobial protein CAP18; CAP18 binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Has antibiotic activity.	Uncharacterized protein.	0.900
CTSG	BPI	ENSOCUP00000001158	ENSOCUP00000011699	Cathepsin G.	Bactericidal permeability-increasing protein; The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.	0.778
CTSG	GSDMD	ENSOCUP00000001158	ENSOCUP00000001621	Cathepsin G.	Gasdermin D.	0.547
CTSG	LTF	ENSOCUP00000001158	ENSOCUP00000015815	Cathepsin G.	Lactotransferrin; Belongs to the transferrin family.	0.813
CTSG	TLR4	ENSOCUP00000001158	ENSOCUP00000001909	Cathepsin G.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.441
DEFB1	DEFB119	ENSOCUP00000021529	ENSOCUP00000028471	Uncharacterized protein.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.752
DEFB1	DEFB136	ENSOCUP00000021529	ENSOCUP00000005401	Uncharacterized protein.	Defensin beta 136.	0.459
DEFB1	LOC103348210	ENSOCUP00000021529	ENSOCUP00000014859	Uncharacterized protein.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.671
DEFB114	DEFB127	ENSOCUP00000042373	ENSOCUP00000002357	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.872
DEFB114	DEFB128	ENSOCUP00000042373	ENSOCUP00000015277	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.859
DEFB114	LOC103348210	ENSOCUP00000042373	ENSOCUP00000014859	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.554
DEFB119	DEFB1	ENSOCUP00000028471	ENSOCUP00000021529	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Uncharacterized protein.	0.752
DEFB119	DEFB127	ENSOCUP00000028471	ENSOCUP00000002357	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.517
DEFB119	DEFB136	ENSOCUP00000028471	ENSOCUP00000005401	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Defensin beta 136.	0.670
DEFB119	LOC103348210	ENSOCUP00000028471	ENSOCUP00000014859	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.529
DEFB127	DEFB114	ENSOCUP00000002357	ENSOCUP00000042373	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.872