STRINGSTRING
ENSOCUP00000041840 ENSOCUP00000041840 CDC14A CDC14A ENSOCUP00000043853 ENSOCUP00000043853 KIF23 KIF23 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000045925 ENSOCUP00000045925 CDC42 CDC42 ENSOCUP00000048173 ENSOCUP00000048173 PKN2 PKN2 CDC42-2 CDC42-2 POLDIP2 POLDIP2 CAT CAT PDGFB PDGFB ENSOCUP00000028463 ENSOCUP00000028463 PTN PTN CUL3 CUL3 LOC103345451 LOC103345451 ENSOCUP00000034177 ENSOCUP00000034177 FGFR2 FGFR2 TGFA TGFA ENSOCUP00000037311 ENSOCUP00000037311 ENSOCUP00000037329 ENSOCUP00000037329 G1U873_RABIT G1U873_RABIT DRD3 DRD3 FGF7 FGF7 HDGFL1 HDGFL1 HDGF HDGF CDC14B CDC14B G1U7N5_RABIT G1U7N5_RABIT G1U373_RABIT G1U373_RABIT ECT2 ECT2 YBX1 YBX1 CENPV CENPV MAP10 MAP10 IL1B IL1B KIF3B KIF3B TAL1 TAL1 VEGFD VEGFD VEGFC VEGFC FGF4 FGF4 GAREM2 GAREM2 CXCR5 CXCR5 PGF PGF PDGFC PDGFC SHH SHH GIPC2 GIPC2 KIF14 KIF14 CIT CIT ITGB1BP1 ITGB1BP1 NKX3-1 NKX3-1 CDC6 CDC6 TGFB2 TGFB2 PDGFA PDGFA PROK2 PROK2 INCENP INCENP G1SV95_RABIT G1SV95_RABIT HTR2B HTR2B IL1A IL1A THBS4 THBS4 GKN1 GKN1 TAS1R2 TAS1R2 SVIL SVIL AURKC AURKC TGFB3 TGFB3 VEGFA VEGFA DRD2 DRD2 G1T2N0_RABIT G1T2N0_RABIT FGF5 FGF5 PROK1 PROK1 PKP4 PKP4 CDC25B CDC25B GAREM1 GAREM1 PRKCE PRKCE FGF1 FGF1 FGF2 FGF2 FGF6 FGF6 KIF20B KIF20B IGF1R IGF1R PDGFD PDGFD RACGAP1 RACGAP1 CSPP1 CSPP1 EREG EREG BTC BTC SIRT2 SIRT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
CDC14ACell division cycle 14A. (625 aa)
ENSOCUP00000043853CSP domain-containing protein. (226 aa)
KIF23Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (968 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
CDC42Uncharacterized protein. (191 aa)
ENSOCUP00000048173Uncharacterized protein. (369 aa)
PKN2Protein kinase N2. (996 aa)
CDC42-2Uncharacterized protein. (222 aa)
POLDIP2DNA polymerase delta interacting protein 2. (433 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (539 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
ENSOCUP00000028463CSD domain-containing protein. (345 aa)
PTNPleiotrophin. (242 aa)
CUL3Cullin 3; Belongs to the cullin family. (771 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000034177Uncharacterized protein. (127 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
TGFATransforming growth factor alpha; TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar (By similarity). Inhibitor of acid secretion. Inhibitor of aminopyrine uptake in parietal cells (in vitro). (185 aa)
ENSOCUP00000037311CSD_1 domain-containing protein. (264 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
G1U873_RABITCSD domain-containing protein. (307 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
HDGFL1Uncharacterized protein. (157 aa)
HDGFHeparin binding growth factor. (240 aa)
CDC14BUncharacterized protein. (560 aa)
G1U7N5_RABITPID domain-containing protein. (200 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
ECT2Epithelial cell transforming 2. (952 aa)
YBX1Y-box-binding protein 1; DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation. Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (By similarity). Promotes mRNA stabilization: acts by binding to m5C- containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (By similarity). Component of the CRD- mediated [...] (352 aa)
CENPVGFA domain-containing protein. (303 aa)
MAP10Microtubule associated protein 10. (832 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
KIF3BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (951 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (319 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
GAREM2GRB2 associated regulator of MAPK1 subtype 2. (648 aa)
CXCR5C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. (374 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
GIPC2GIPC PDZ domain containing family member 2. (259 aa)
KIF14Kinesin family member 14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1633 aa)
CITCitron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (2070 aa)
ITGB1BP1PID domain-containing protein. (200 aa)
NKX3-1NK3 homeobox 1. (159 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (560 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
PDGFAPlatelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] (150 aa)
PROK2Prokineticin 2. (106 aa)
INCENPInner centromere protein. (904 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. (267 aa)
THBS4Thrombospondin 4. (997 aa)
GKN1Gastrokine 1. (183 aa)
TAS1R2Taste 1 receptor member 2. (836 aa)
SVILSupervillin. (2121 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (292 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (398 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
G1T2N0_RABITPWWP domain-containing protein. (176 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (267 aa)
PROK1Prokineticin 1. (105 aa)
PKP4Plakophilin 4. (1191 aa)
CDC25BCell division cycle 25B. (413 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (923 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (744 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
KIF20BKinesin family member 20B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1758 aa)
IGF1RTyrosine-protein kinase receptor. (1464 aa)
PDGFDPlatelet-derived growth factor D, receptor-binding form; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). (538 aa)
RACGAP1Rac GTPase activating protein 1. (634 aa)
CSPP1Centrosome and spindle pole associated protein 1. (1216 aa)
EREGEpiregulin. (169 aa)
BTCBetacellulin. (212 aa)
SIRT2Sirtuin 2. (509 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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