STRINGSTRING
C1QTNF1 C1QTNF1 THBS1 THBS1 ITGB1 ITGB1 STOX1 STOX1 P2RX4 P2RX4 G1SGM6_RABIT G1SGM6_RABIT PTPRJ PTPRJ IL26 IL26 FGF2 FGF2 FAM110C FAM110C LOC100357100 LOC100357100 ITGB1BP1 ITGB1BP1 ENSOCUP00000049280 ENSOCUP00000049280 PHB PHB ANGPT1 ANGPT1 ENSOCUP00000047686 ENSOCUP00000047686 ENSOCUP00000045925 ENSOCUP00000045925 ADAM8 ADAM8 HAX1 HAX1 ENSOCUP00000045339 ENSOCUP00000045339 ENSOCUP00000044284 ENSOCUP00000044284 FAM110D FAM110D INSR INSR NOX4 NOX4 ENSOCUP00000041840 ENSOCUP00000041840 FGFR1 FGFR1 ENSOCUP00000041421 ENSOCUP00000041421 ENSOCUP00000040784 ENSOCUP00000040784 MEIS3 MEIS3 OSBPL8 OSBPL8 CCL19 CCL19 mc1R mc1R PTK2-2 PTK2-2 HBEGF HBEGF ENSOCUP00000037329 ENSOCUP00000037329 RET RET TGFBR1 TGFBR1 TCF7L2 TCF7L2 FAM110A FAM110A NRG1 NRG1 ENSOCUP00000033799 ENSOCUP00000033799 GCNT2 GCNT2 ENSOCUP00000033220 ENSOCUP00000033220 LOC103345451 LOC103345451 ENSOCUP00000031621 ENSOCUP00000031621 PTK2 PTK2 F3 F3 FERMT2 FERMT2 PIK3CA PIK3CA G1U7N5_RABIT G1U7N5_RABIT CD28 CD28 F10 F10 IGFBP5 IGFBP5 MFHAS1 MFHAS1 ENSOCUP00000023367 ENSOCUP00000023367 PIK3R5 PIK3R5 GFRAL GFRAL PIK3CD PIK3CD CCL21 CCL21 INS INS RASD2 RASD2 TSPYL5 TSPYL5 FAM110B FAM110B CHI3L1 CHI3L1 RICTOR RICTOR TNFSF11 TNFSF11 CASS4 CASS4 GATA3 GATA3 TEK TEK AXL AXL EGF EGF MYOC MYOC BAG4 BAG4 IGF1R IGF1R PIK3CG PIK3CG HCLS1 HCLS1 TNFAIP8L3 TNFAIP8L3 RTN4 RTN4 HPSE HPSE LRP2 LRP2 EGFR EGFR NTS NTS OSM OSM LEP LEP CSF3 CSF3 SPRY2 SPRY2 MST1R MST1R G1SV95_RABIT G1SV95_RABIT CX3CL1 CX3CL1 ENG ENG THPO THPO TNF TNF PDGFA PDGFA IL18 IL18 PIK3CB PIK3CB STK3 STK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C1QTNF1C1q and TNF related 1. (182 aa)
THBS1Thrombospondin 1. (1171 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (830 aa)
STOX1Storkhead box 1. (977 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (387 aa)
G1SGM6_RABITUncharacterized protein. (186 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1330 aa)
IL26Interleukin 26. (180 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
FAM110CFamily with sequence similarity 110 member C. (303 aa)
LOC100357100CCHC-type domain-containing protein. (209 aa)
ITGB1BP1PID domain-containing protein. (200 aa)
ENSOCUP00000049280SCY domain-containing protein. (136 aa)
PHBProhibitin. (303 aa)
ANGPT1Angiopoietin 1. (551 aa)
ENSOCUP00000047686C1q domain-containing protein. (471 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ADAM8ADAM metallopeptidase domain 8. (978 aa)
HAX1Uncharacterized protein. (426 aa)
ENSOCUP00000045339Uncharacterized protein. (163 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
FAM110DFamily with sequence similarity 110 member D. (244 aa)
INSRTyrosine-protein kinase receptor. (1377 aa)
NOX4NADPH oxidase 4. (638 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
ENSOCUP00000041421CCHC-type domain-containing protein. (189 aa)
ENSOCUP00000040784Uncharacterized protein. (227 aa)
MEIS3Meis homeobox 3. (523 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (887 aa)
CCL19C-C motif chemokine. (109 aa)
mc1RMelanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (307 aa)
PTK2-2FERM_N_2 domain-containing protein. (121 aa)
HBEGFHeparin binding EGF like growth factor. (228 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
TCF7L2Transcription factor 7 like 2. (605 aa)
FAM110AFamily with sequence similarity 110 member A. (380 aa)
NRG1Neuregulin 1. (720 aa)
ENSOCUP00000033799Uncharacterized protein. (545 aa)
GCNT2Uncharacterized protein. (402 aa)
ENSOCUP00000033220Prohibitin. (262 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000031621Uncharacterized protein. (1225 aa)
PTK2Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1041 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (397 aa)
FERMT2Fermitin family member 2. (696 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
G1U7N5_RABITPID domain-containing protein. (200 aa)
CD28T-cell-specific surface glycoprotein CD28; Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. (255 aa)
F10Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting; Belongs to the peptidase S1 family. (560 aa)
IGFBP5Insulin like growth factor binding protein 5. (271 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
ENSOCUP00000023367annotation not available (209 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (880 aa)
GFRALGDNF family receptor alpha like. (555 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1039 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
RASD2RASD family member 2. (266 aa)
TSPYL5TSPY like 5; Belongs to the nucleosome assembly protein (NAP) family. (416 aa)
FAM110BFamily with sequence similarity 110 member B. (378 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (383 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
CASS4Cas scaffold protein family member 4. (800 aa)
GATA3GATA binding protein 3. (444 aa)
TEKTEK receptor tyrosine kinase. (1025 aa)
AXLAXL receptor tyrosine kinase. (625 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1198 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (490 aa)
BAG4BCL2 associated athanogene 4. (459 aa)
IGF1RTyrosine-protein kinase receptor. (1464 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (487 aa)
TNFAIP8L3TNF alpha induced protein 8 like 3. (204 aa)
RTN4Reticulon. (1110 aa)
HPSEHeparanase. (681 aa)
LRP2Uncharacterized protein. (2726 aa)
EGFRReceptor protein-tyrosine kinase. (1193 aa)
NTSNeurotensin. (170 aa)
OSMUncharacterized protein. (333 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
CSF3Colony stimulating factor 3. (204 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
MST1RMacrophage stimulating 1 receptor. (1392 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
ENGEndoglin. (758 aa)
THPOThrombopoietin. (348 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
PDGFAPlatelet-derived growth factor subunit A; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by t [...] (150 aa)
IL18Uncharacterized protein. (408 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
STK3Serine/threonine kinase 3. (491 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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