(16 nodes) Cardiac myofibril assembly network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PROX1	Prospero homeobox 1. (737 aa)
	NEBL	Nebulette. (1035 aa)
	ENSOCUP00000042043	Ig-like domain-containing protein. (212 aa)
	NEB	Nebulin. (6666 aa)
	FHOD3	Formin homology 2 domain containing 3. (1602 aa)
	PDGFRB	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1147 aa)
	SRF	Serum response factor. (685 aa)
	ACTC1	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
	NRAP	Nebulin related anchoring protein. (1743 aa)
	MEF2A	Myocyte enhancer factor 2A. (511 aa)
	ADPRHL1	ADP-ribosylhydrolase like 1. (353 aa)
	TCAP	Titin-cap. (179 aa)
	PDGFRA	Protein kinase domain-containing protein. (773 aa)
	NKX2-5	NK2 homeobox 5. (326 aa)
	CSRP3	Cysteine and glycine rich protein 3. (245 aa)
	MYLK3	Myosin light chain kinase 3. (862 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	CSRP3	ENSOCUP00000006542	ENSOCUP00000036808	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Cysteine and glycine rich protein 3.	0.554
ACTC1	NEB	ENSOCUP00000006542	ENSOCUP00000048133	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Nebulin.	0.639
ACTC1	NKX2-5	ENSOCUP00000006542	ENSOCUP00000000038	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	NK2 homeobox 5.	0.567
ACTC1	SRF	ENSOCUP00000006542	ENSOCUP00000002515	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Serum response factor.	0.444
ACTC1	TCAP	ENSOCUP00000006542	ENSOCUP00000021853	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Titin-cap.	0.530
CSRP3	ACTC1	ENSOCUP00000036808	ENSOCUP00000006542	Cysteine and glycine rich protein 3.	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	0.554
CSRP3	NEB	ENSOCUP00000036808	ENSOCUP00000048133	Cysteine and glycine rich protein 3.	Nebulin.	0.577
CSRP3	NRAP	ENSOCUP00000036808	ENSOCUP00000009489	Cysteine and glycine rich protein 3.	Nebulin related anchoring protein.	0.596
CSRP3	TCAP	ENSOCUP00000036808	ENSOCUP00000021853	Cysteine and glycine rich protein 3.	Titin-cap.	0.935
ENSOCUP00000042043	PDGFRA	ENSOCUP00000042043	ENSOCUP00000000224	Ig-like domain-containing protein.	Protein kinase domain-containing protein.	0.900
ENSOCUP00000042043	PDGFRB	ENSOCUP00000042043	ENSOCUP00000001483	Ig-like domain-containing protein.	Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.	0.755
MEF2A	NKX2-5	ENSOCUP00000018692	ENSOCUP00000000038	Myocyte enhancer factor 2A.	NK2 homeobox 5.	0.903
MEF2A	SRF	ENSOCUP00000018692	ENSOCUP00000002515	Myocyte enhancer factor 2A.	Serum response factor.	0.484
NEB	ACTC1	ENSOCUP00000048133	ENSOCUP00000006542	Nebulin.	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	0.639
NEB	CSRP3	ENSOCUP00000048133	ENSOCUP00000036808	Nebulin.	Cysteine and glycine rich protein 3.	0.577
NEB	NRAP	ENSOCUP00000048133	ENSOCUP00000009489	Nebulin.	Nebulin related anchoring protein.	0.644
NEB	TCAP	ENSOCUP00000048133	ENSOCUP00000021853	Nebulin.	Titin-cap.	0.775
NEBL	TCAP	ENSOCUP00000041629	ENSOCUP00000021853	Nebulette.	Titin-cap.	0.665
NKX2-5	ACTC1	ENSOCUP00000000038	ENSOCUP00000006542	NK2 homeobox 5.	Actin, alpha skeletal muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	0.567
NKX2-5	MEF2A	ENSOCUP00000000038	ENSOCUP00000018692	NK2 homeobox 5.	Myocyte enhancer factor 2A.	0.903