STRINGSTRING
EDNRA EDNRA TNNT2 TNNT2 SMAD7 SMAD7 BMPR1A BMPR1A TGFBR3 TGFBR3 TPM1 TPM1 DSP DSP HAND1 HAND1 LRP2 LRP2 DLL4 DLL4 TNNI1 TNNI1 BMP10 BMP10 CHD7 CHD7 MED1 MED1 HEY2 HEY2 MYL3 MYL3 PKP2 PKP2 ENSOCUP00000031621 ENSOCUP00000031621 MYL10 MYL10 G1SV95_RABIT G1SV95_RABIT TNNC1 TNNC1 ENG ENG POU4F1 POU4F1 ZFPM2 ZFPM2 TGFB2 TGFB2 SMAD4 SMAD4 RYR2 RYR2 G1TQE3_RABIT G1TQE3_RABIT ISL1 ISL1 ENSOCUP00000045925 ENSOCUP00000045925 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000041840 ENSOCUP00000041840 PROX1 PROX1 ENSOCUP00000037329 ENSOCUP00000037329 TGFBR1 TGFBR1 FGFR2 FGFR2 NRG1 NRG1 NKX2-5 NKX2-5 COL11A1 COL11A1 LOC103345451 LOC103345451 MYBPC3 MYBPC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
TNNT2Troponin T, cardiac muscle; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (341 aa)
SMAD7Mothers against decapentaplegic homolog. (549 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
TPM1Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (326 aa)
DSPDesmoplakin. (2814 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1; Transcription factor that plays an essential role in both trophoblast giant cell differentiation and in cardiac morphogenesis (By similarity). Binds the DNA sequence 5'-NRTCTG-3' (non-canonical E-box) (By similarity). Acts as a transcriptional repressor of SOX15 (By similarity). In the adult, could be required for ongoing expression of cardiac-specific genes (By similarity). (215 aa)
LRP2Uncharacterized protein. (2726 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
TNNI1Troponin I, slow skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (187 aa)
BMP10Bone morphogenetic protein 10. (428 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2997 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1580 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (338 aa)
MYL3Myosin light chain 3. (327 aa)
PKP2Plakophilin 2. (773 aa)
ENSOCUP00000031621Uncharacterized protein. (1225 aa)
MYL10Myosin light chain 10. (167 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (161 aa)
ENGEndoglin. (758 aa)
POU4F1POU domain protein. (339 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1159 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RYR2Ryanodine receptor 2; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. Required for cellular calcium ion homeostasis. Required for embryonic heart development (By similarity). The calcium channel activity is modulated by formation of heterotetramers with RYR3; Belongs to t [...] (4965 aa)
G1TQE3_RABITFork-head domain-containing protein. (520 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
NRG1Neuregulin 1. (720 aa)
NKX2-5NK2 homeobox 5. (326 aa)
COL11A1Collagen type XI alpha 1 chain. (1857 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
MYBPC3Myosin binding protein C, cardiac. (1250 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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