STRINGSTRING
EFEMP1 EFEMP1 WNT5A WNT5A RARB RARB TAPT1 TAPT1 TRPS1 TRPS1 PKDCC PKDCC BMP6 BMP6 GLG1 GLG1 CCN1 CCN1 PTPN11 PTPN11 ADAMTS12 ADAMTS12 GLI3 GLI3 GDF6 GDF6 PRKG2 PRKG2 G1SV95_RABIT G1SV95_RABIT NKX3-2 NKX3-2 BMP10 BMP10 FRZB FRZB GDF5 GDF5 CTSK CTSK BMP4 BMP4 SMPD3 SMPD3 BMP2 BMP2 SNAI2 SNAI2 KAT2A KAT2A GDF2 GDF2 ENSOCUP00000037329 ENSOCUP00000037329 BMPR2 BMPR2 TGFBR1 TGFBR1 SMAD1 SMAD1 FGF18 FGF18 SCIN SCIN CTNNB1 CTNNB1 ENSOCUP00000032400 ENSOCUP00000032400 LOC103345451 LOC103345451 SOX6 SOX6 ZBTB16 ZBTB16 BMP1 BMP1 SHOX2 SHOX2 SMAD3 SMAD3 IHH IHH ZNF219 ZNF219 WNT9A WNT9A RFLNB RFLNB SIX2 SIX2 G1TVI4_RABIT G1TVI4_RABIT GREM1 GREM1 SMAD7 SMAD7 RARA RARA MBOAT2 MBOAT2 G1TBJ9_RABIT G1TBJ9_RABIT POR POR SOX5 SOX5 ENSOCUP00000041840 ENSOCUP00000041840 RARG RARG LOXL3 LOXL3 BMPR1B BMPR1B ENSOCUP00000044284 ENSOCUP00000044284 CCN4 CCN4 ENSOCUP00000045925 ENSOCUP00000045925 AXIN2 AXIN2 CHADL CHADL MUSTN1 MUSTN1 ADAMTS7 ADAMTS7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EFEMP1EGF containing fibulin extracellular matrix protein 1. (494 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
RARBRetinoic acid receptor beta. (448 aa)
TAPT1Transmembrane anterior posterior transformation 1. (516 aa)
TRPS1Transcriptional repressor GATA binding 1. (1290 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (372 aa)
BMP6Bone morphogenetic protein 6. (411 aa)
GLG1Golgi glycoprotein 1. (1225 aa)
CCN1Cellular communication network factor 1. (386 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
GLI3GLI family zinc finger 3. (1575 aa)
GDF6Growth differentiation factor 6. (427 aa)
PRKG2cGMP-dependent protein kinase. (762 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
NKX3-2NK3 homeobox 2. (333 aa)
BMP10Bone morphogenetic protein 10. (428 aa)
FRZBFrizzled related protein. (318 aa)
GDF5Growth differentiation factor 5 preproprotein (Predicted). (500 aa)
CTSKCathepsin K; Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen. Belongs to the peptidase C1 family. (329 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (657 aa)
BMP2Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
SNAI2Uncharacterized protein. (268 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (795 aa)
GDF2Growth differentiation factor 2. (434 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
FGF18Fibroblast growth factor 18; Belongs to the heparin-binding growth factors family. (231 aa)
SCINScinderin. (759 aa)
CTNNB1Catenin beta 1. (741 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SOX6SRY-box transcription factor 6. (855 aa)
ZBTB16Zinc finger and BTB domain containing 16. (762 aa)
BMP1Metalloendopeptidase. (984 aa)
SHOX2Short stature homeobox 2. (211 aa)
SMAD3SMAD family member 3. (230 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
ZNF219Zinc finger protein 219. (700 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (538 aa)
RFLNBRefilin B. (214 aa)
SIX2SIX homeobox 2. (295 aa)
G1TVI4_RABITNR LBD domain-containing protein. (321 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
SMAD7Mothers against decapentaplegic homolog. (549 aa)
RARARetinoic acid receptor alpha. (462 aa)
MBOAT2Membrane bound O-acyltransferase domain containing 2; Belongs to the membrane-bound acyltransferase family. (500 aa)
G1TBJ9_RABITUncharacterized protein. (276 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the N-terminal section; belongs to the flavodoxin family. (439 aa)
SOX5SRY-box transcription factor 5. (779 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RARGUncharacterized protein. (415 aa)
LOXL3Lysyl oxidase like 3. (935 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
CCN4Cellular communication network factor 4. (337 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
AXIN2Axin 2. (816 aa)
CHADLChondroadherin like. (807 aa)
MUSTN1Uncharacterized protein. (82 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1654 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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