(43 nodes) Protein K63-linked deubiquitination network (Oryctolagus cuniculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	OTUD5	OTU deubiquitinase 5. (566 aa)
	UIMC1	Ubiquitin interaction motif containing 1. (720 aa)
	TNFAIP3	TNF alpha induced protein 3. (787 aa)
	STAMBP	STAM binding protein. (432 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1088 aa)
	USP25	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family. (1152 aa)
	ABRAXAS2	Abraxas 2, BRISC complex subunit. (440 aa)
	ATXN3	Josephin domain-containing protein. (363 aa)
	USP13	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (845 aa)
	USP33	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (876 aa)
	ZRANB1	Zinc finger RANBP2-type containing 1. (708 aa)
	DESI2	Desumoylating isopeptidase 2. (194 aa)
	ABRAXAS1	Abraxas 1, BRCA1 A complex subunit. (409 aa)
	OTUD7A	OTU deubiquitinase 7A. (853 aa)
	OTUD7B	OTU deubiquitinase 7B. (843 aa)
	YOD1	YOD1 deubiquitinase. (348 aa)
	OTUD4	OTU deubiquitinase 4. (1042 aa)
	SPATA2	Spermatogenesis associated 2. (509 aa)
	SHMT2	Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...] (502 aa)
	BRCC3	BRCA1/BRCA2-containing complex subunit 3. (291 aa)
	U3KME9_RABIT	Reverse transcriptase domain-containing protein. (724 aa)
	USP7	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1161 aa)
	ENSOCUP00000027970	Reverse transcriptase domain-containing protein. (739 aa)
	ENSOCUP00000028528	Reverse transcriptase domain-containing protein. (724 aa)
	ENSOCUP00000028796	Reverse transcriptase domain-containing protein. (1042 aa)
	USP16	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (851 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
	STAMBPL1	STAM binding protein like 1. (469 aa)
	ENSOCUP00000034899	Reverse transcriptase domain-containing protein. (724 aa)
	ENSOCUP00000036167	Reverse transcriptase domain-containing protein. (739 aa)
	OTUB2	OTU deubiquitinase, ubiquitin aldehyde binding 2. (285 aa)
	ENSOCUP00000037652	Reverse transcriptase domain-containing protein. (1286 aa)
	ENSOCUP00000038225	Reverse transcriptase domain-containing protein. (1130 aa)
	ENSOCUP00000039819	Reverse transcriptase domain-containing protein. (884 aa)
	ENSOCUP00000040662	Reverse transcriptase domain-containing protein. (857 aa)
	ENSOCUP00000040990	Josephin domain-containing protein. (123 aa)
	ENSOCUP00000042067	Reverse transcriptase domain-containing protein. (739 aa)
	ENSOCUP00000043520	Reverse transcriptase domain-containing protein. (1033 aa)
	ENSOCUP00000044088	Reverse transcriptase domain-containing protein. (344 aa)
	ENSOCUP00000045127	DUF1725 domain-containing protein. (763 aa)
	PSMD14	Proteasome 26S subunit, non-ATPase 14. (317 aa)
	USP20	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (899 aa)
	ENSOCUP00000049612	Reverse transcriptase domain-containing protein. (854 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABRAXAS1	BRCC3	ENSOCUP00000011470	ENSOCUP00000021158	Abraxas 1, BRCA1 A complex subunit.	BRCA1/BRCA2-containing complex subunit 3.	0.973
ABRAXAS1	SHMT2	ENSOCUP00000011470	ENSOCUP00000019769	Abraxas 1, BRCA1 A complex subunit.	Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...]	0.586
ABRAXAS2	BRCC3	ENSOCUP00000004137	ENSOCUP00000021158	Abraxas 2, BRISC complex subunit.	BRCA1/BRCA2-containing complex subunit 3.	0.995
ABRAXAS2	SHMT2	ENSOCUP00000004137	ENSOCUP00000019769	Abraxas 2, BRISC complex subunit.	Serine hydroxymethyltransferase, mitochondrial; Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial tran [...]	0.920
ABRAXAS2	UIMC1	ENSOCUP00000004137	ENSOCUP00000000354	Abraxas 2, BRISC complex subunit.	Ubiquitin interaction motif containing 1.	0.687
ABRAXAS2	USP7	ENSOCUP00000004137	ENSOCUP00000026870	Abraxas 2, BRISC complex subunit.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.423
ATXN3	OTUD4	ENSOCUP00000004940	ENSOCUP00000012526	Josephin domain-containing protein.	OTU deubiquitinase 4.	0.509
ATXN3	OTUD5	ENSOCUP00000004940	ENSOCUP00000013546	Josephin domain-containing protein.	OTU deubiquitinase 5.	0.457
ATXN3	PSMD14	ENSOCUP00000004940	ENSOCUP00000047048	Josephin domain-containing protein.	Proteasome 26S subunit, non-ATPase 14.	0.500
ATXN3	USP13	ENSOCUP00000004940	ENSOCUP00000005236	Josephin domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.	0.756
ATXN3	USP25	ENSOCUP00000004940	ENSOCUP00000004100	Josephin domain-containing protein.	Ubiquitin specific peptidase 25; Belongs to the peptidase C19 family.	0.693
ATXN3	USP7	ENSOCUP00000004940	ENSOCUP00000026870	Josephin domain-containing protein.	Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family.	0.626
ATXN3	USP8	ENSOCUP00000004940	ENSOCUP00000003197	Josephin domain-containing protein.	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family.	0.516
ATXN3	YOD1	ENSOCUP00000004940	ENSOCUP00000012332	Josephin domain-containing protein.	YOD1 deubiquitinase.	0.460
BRCC3	ABRAXAS1	ENSOCUP00000021158	ENSOCUP00000011470	BRCA1/BRCA2-containing complex subunit 3.	Abraxas 1, BRCA1 A complex subunit.	0.973
BRCC3	ABRAXAS2	ENSOCUP00000021158	ENSOCUP00000004137	BRCA1/BRCA2-containing complex subunit 3.	Abraxas 2, BRISC complex subunit.	0.995
BRCC3	ENSOCUP00000027970	ENSOCUP00000021158	ENSOCUP00000027970	BRCA1/BRCA2-containing complex subunit 3.	Reverse transcriptase domain-containing protein.	0.433
BRCC3	ENSOCUP00000028528	ENSOCUP00000021158	ENSOCUP00000028528	BRCA1/BRCA2-containing complex subunit 3.	Reverse transcriptase domain-containing protein.	0.433
BRCC3	ENSOCUP00000028796	ENSOCUP00000021158	ENSOCUP00000028796	BRCA1/BRCA2-containing complex subunit 3.	Reverse transcriptase domain-containing protein.	0.433
BRCC3	ENSOCUP00000034899	ENSOCUP00000021158	ENSOCUP00000034899	BRCA1/BRCA2-containing complex subunit 3.	Reverse transcriptase domain-containing protein.	0.433