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| | SPIDR | Scaffold protein involved in DNA repair. (920 aa) |
| | DDB1 | Damage specific DNA binding protein 1. (1140 aa) |
| | BARD1 | BRCA1 associated RING domain 1. (751 aa) |
| | LTBR | Lymphotoxin beta receptor. (414 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa) |
| | PTGER4 | Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. (488 aa) |
| | AKT2 | AKT serine/threonine kinase 2. (442 aa) |
| | METTL3 | Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa) |
| | PBK | PDZ binding kinase. (322 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (848 aa) |
| | RAD9B | Uncharacterized protein. (637 aa) |
| | PKD1L3 | Uncharacterized protein. (1652 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1976 aa) |
| | IRF1 | Interferon regulatory factor. (336 aa) |
| | MAPK13 | Mitogen-activated protein kinase. (399 aa) |
| | CASP9 | Caspase 9; Belongs to the peptidase C14A family. (466 aa) |
| | RUVBL2 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa) |
| | NOC2L | NOC2 like nucleolar associated transcriptional repressor. (685 aa) |
| | ENSOCUP00000046340 | RHD domain-containing protein. (343 aa) |
| | TNFSF14 | TNF superfamily member 14. (241 aa) |
| | ENSOCUP00000045925 | TGFb_propeptide domain-containing protein. (272 aa) |
| | TNFRSF1A | TNF receptor superfamily member 1A. (472 aa) |
| | ENSOCUP00000045399 | Uncharacterized protein. (182 aa) |
| | GCLC | Glutamate-cysteine ligase catalytic subunit. (664 aa) |
| | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. (260 aa) |
| | TSPO | Uncharacterized protein. (516 aa) |
| | RCSD1 | RCSD domain containing 1. (436 aa) |
| | DHX36 | DEAH-box helicase 36. (1468 aa) |
| | PTPRK | Protein tyrosine phosphatase receptor type K. (1472 aa) |
| | ENSOCUP00000043082 | Uncharacterized protein. (319 aa) |
| | GRB2 | Growth factor receptor bound protein 2. (278 aa) |
| | ELK1 | ETS transcription factor ELK1. (512 aa) |
| | ENSOCUP00000041840 | TGFb_propeptide domain-containing protein. (219 aa) |
| | CRB1 | Crumbs cell polarity complex component 1. (1405 aa) |
| | MME | Neprilysin; Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. Belongs to the peptidase M13 family. (750 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2725 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (901 aa) |
| | ENSOCUP00000040237 | DUF4502 domain-containing protein. (114 aa) |
| | POLH | DNA polymerase eta. (733 aa) |
| | GHRHR | Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa) |
| | ENSOCUP00000039002 | Uncharacterized protein. (163 aa) |
| | mc1R | Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. (307 aa) |
| | F11R | F11 receptor. (314 aa) |
| | RAB11FIP5 | Uncharacterized protein. (1311 aa) |
| | DNM2 | Dynamin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (846 aa) |
| | RHOB | Ras homolog family member B. (196 aa) |
| | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. (263 aa) |
| | ACTR5 | Actin related protein 5; Belongs to the actin family. (652 aa) |
| | MMP1 | Interstitial collagenase; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X; Belongs to the peptidase M10A family. (475 aa) |
| | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1. (1408 aa) |
| | MAP2K4 | Mitogen-activated protein kinase kinase 4. (520 aa) |
| | CAPN3 | Uncharacterized protein; Belongs to the peptidase C2 family. (820 aa) |
| | SLC2A4 | MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (574 aa) |
| | MYD88 | Uncharacterized protein. (476 aa) |
| | CD40 | Uncharacterized protein. (494 aa) |
| | YBX3 | Y-box binding protein 3. (453 aa) |
| | MMP2 | 72 kDa type IV collagenase; Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta- type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3 [...] (710 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (852 aa) |
| | NET1 | Neuroepithelial cell transforming 1. (596 aa) |
| | EIF2S1 | Eukaryotic translation initiation factor 2 subunit 1; Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre- initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF- 2 must exchange with GTP by way of a reaction catalyzed [...] (292 aa) |
| | ITGB3 | Integrin beta; Belongs to the integrin beta chain family. (873 aa) |
| | ASIC1 | Acid sensing ion channel subunit 1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (562 aa) |
| | RIPOR2 | RHO family interacting cell polarization regulator 2. (1110 aa) |
| | HSF1 | Heat shock transcription factor 1. (680 aa) |
| | LOC103345451 | TGFb_propeptide domain-containing protein. (203 aa) |
| | OPN5 | Opsin 5; Belongs to the G-protein coupled receptor 1 family. (366 aa) |
| | RAD9A | RAD9 checkpoint clamp component A. (544 aa) |
| | ENSOCUP00000030953 | IRF tryptophan pentad repeat domain-containing protein. (200 aa) |
| | NFATC4 | Nuclear factor of activated T cells 4. (933 aa) |
| | TLK2 | Tousled like kinase 2. (984 aa) |
| | SLC38A2 | Solute carrier family 38 member 2. (563 aa) |
| | ENSOCUP00000029917 | Uncharacterized protein. (169 aa) |
| | SLC38A3 | Solute carrier family 38 member 3. (521 aa) |
| | CIITA | Class II major histocompatibility complex transactivator. (1175 aa) |
| | ITGA2 | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa) |
| | ITGB6 | Integrin beta; Belongs to the integrin beta chain family. (787 aa) |
| | PRKCD | Uncharacterized protein. (807 aa) |
| | RDH11 | Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (418 aa) |
| | RRH | Retinal pigment epithelium-derived rhodopsin homolog; Belongs to the G-protein coupled receptor 1 family. (337 aa) |
| | USP28 | Ubiquitin specific peptidase 28; Belongs to the peptidase C19 family. (1041 aa) |
| | USP47 | Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa) |
| | PRAP1 | Uncharacterized protein. (189 aa) |
| | TLR8 | Toll like receptor 8; Belongs to the Toll-like receptor family. (1030 aa) |
| | INTS7 | Integrator complex subunit 7. (962 aa) |
| | BAK1 | BCL2 antagonist/killer 1. (210 aa) |
| | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa) |
| | AQP10 | Aquaporin 10; Belongs to the MIP/aquaporin (TC 1.A.8) family. (293 aa) |
| | G1U940_RABIT | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa) |
| | LRRC8D | Leucine rich repeat containing 8 VRAC subunit D. (811 aa) |
| | LRRC8E | Leucine rich repeat containing 8 VRAC subunit E. (827 aa) |
| | SCN2A | Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2006 aa) |
| | MMP9 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). (707 aa) |
| | GTF2H5 | General transcription factor IIH subunit 5. (71 aa) |
| | ERCC1 | Uncharacterized protein. (226 aa) |
| | G1U4Q8_RABIT | G_PROTEIN_RECEP_F1_2 domain-containing protein. (140 aa) |
| | PDE2A | Phosphodiesterase. (936 aa) |
| | G1U4L1_RABIT | Uncharacterized protein. (195 aa) |
| | NFKB1 | Nuclear factor kappa B subunit 1. (968 aa) |
| | ECT2 | Epithelial cell transforming 2. (952 aa) |
| | SLC9A1 | Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa) |
| | SIRT1 | Sirtuin 1. (748 aa) |
| | MAG | Uncharacterized protein. (58 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa) |
| | HABP4 | HABP4_PAI-RBP1 domain-containing protein. (182 aa) |
| | TNKS1BP1 | Tankyrase 1 binding protein 1. (1669 aa) |
| | PALM | Uncharacterized protein. (622 aa) |
| | TREX1 | Three prime repair exonuclease 1. (314 aa) |
| | CASP10 | Caspase-10; Belongs to the peptidase C14A family. (469 aa) |
| | MAPK8 | Mitogen-activated protein kinase. (427 aa) |
| | G1TPI1_RABIT | Uncharacterized protein. (57 aa) |
| | TANK | TRAF family member associated NFKB activator. (425 aa) |
| | HPCAL1 | Hippocalcin like 1. (193 aa) |
| | TSPYL5 | TSPY like 5; Belongs to the nucleosome assembly protein (NAP) family. (416 aa) |
| | G1TLX8_RABIT | RING-type domain-containing protein. (248 aa) |
| | AVPR1A | Vasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (418 aa) |
| | TMEM150C | Transmembrane protein 150C. (249 aa) |
| | G1TKQ0_RABIT | ANK_REP_REGION domain-containing protein. (118 aa) |
| | HYAL3 | Hyaluronidase. (492 aa) |
| | NUCKS1 | Nuclear casein kinase and cyclin dependent kinase substrate 1. (304 aa) |
| | SCNN1A | Amiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. (491 aa) |
| | CHEK2 | Checkpoint kinase 2. (538 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | STK39 | Serine/threonine kinase 39. (544 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa) |
| | TLR3 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa) |
| | OPN4 | Opsin 4. (472 aa) |
| | NSMF | NMDA receptor synaptonuclear signaling and neuronal migration factor. (469 aa) |
| | RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Part of a PALB2-scaffolded HR [...] (339 aa) |
| | BRCA2 | BRCA2 DNA repair associated. (3412 aa) |
| | PTGS2 | Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa) |
| | SFRP2 | Secreted frizzled related protein 2. (295 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (244 aa) |
| | CDKN1A | Uncharacterized protein. (231 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | SMPD1 | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa) |
| | LIG4 | DNA ligase. (911 aa) |
| | TMEM109 | Transmembrane protein 109; May mediate cellular response to DNA damage by protecting against ultraviolet C-induced cell death (By similarity). Can form voltage-gated calcium and potassium channels in vitro. (243 aa) |
| | CCND2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (431 aa) |
| | SLC24A4 | Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (613 aa) |
| | MMP3 | Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (478 aa) |
| | MFAP4 | Microfibril associated protein 4. (258 aa) |
| | MAP3K20 | Mitogen-activated protein kinase kinase kinase 20. (875 aa) |
| | KCNK18 | Potassium two pore domain channel subfamily K member 18; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (385 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (909 aa) |
| | BDKRB2 | B2 bradykinin receptor; Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. (446 aa) |
| | IGF1R | Tyrosine-protein kinase receptor. (1464 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (282 aa) |
| | BLM | BLM RecQ like helicase. (1414 aa) |
| | IMPACT | Protein IMPACT; Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 ac [...] (449 aa) |
| | XPA | XPA, DNA damage recognition and repair factor. (248 aa) |
| | CHP1 | Calcineurin like EF-hand protein 1. (194 aa) |
| | IL33 | Uncharacterized protein. (142 aa) |
| | GPR68 | G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa) |
| | HPCA | Hippocalcin. (193 aa) |
| | RPE65 | Retinoid isomerohydrolase RPE65. (533 aa) |
| | PKD2L1 | Polycystin 2 like 1, transient receptor potential cation channel. (796 aa) |
| | RHO | Rhodopsin; Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth (By similarity). Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G- proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (By similarity). (355 aa) |
| | CRYAB | Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions; Belongs to the small heat shock protein (HSP20) family. (175 aa) |
| | N4BP1 | NEDD4 binding protein 1. (866 aa) |
| | WRN | WRN RecQ like helicase. (1360 aa) |
| | SNAI2 | Uncharacterized protein. (268 aa) |
| | TRPV1 | Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Ac [...] (842 aa) |
| | GPR88 | G protein-coupled receptor 88. (384 aa) |
| | HVCN1 | Hydrogen voltage gated channel 1. (316 aa) |
| | GNB5 | Guanine nucleotide-binding protein subunit beta-5; Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (Probable). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, incl [...] (372 aa) |
| | MCOLN1 | Mucolipin 1. (578 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (644 aa) |
| | BAG3 | BCL2 associated athanogene 3. (805 aa) |
| | WNK3 | WNK lysine deficient protein kinase 3. (1793 aa) |
| | EP300 | E1A binding protein p300. (2418 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (1003 aa) |
| | LRRC8C | Leucine rich repeat containing 8 VRAC subunit C. (803 aa) |
| | INO80 | INO80 complex ATPase subunit. (1559 aa) |
| | TIMP1 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (256 aa) |
| | BABAM2 | BRISC and BRCA1 A complex member 2. (407 aa) |
| | INSRR | Tyrosine-protein kinase receptor. (1320 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (467 aa) |
| | TRIAP1 | TP53 regulated inhibitor of apoptosis 1. (76 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (759 aa) |
| | TENT2 | Terminal nucleotidyltransferase 2. (484 aa) |
| | FBXO4 | F-box protein 4. (387 aa) |
| | PTEN | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa) |
| | G1SV95_RABIT | Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa) |
| | EGR1 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa) |
| | SCNN1B | Amiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...] (641 aa) |
| | OPN1SW | Opsin 1, short wave sensitive. (348 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (240 aa) |
| | OPN3 | G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (408 aa) |
| | RHBDD1 | Rhomboid domain containing 1. (343 aa) |
| | ENG | Endoglin. (758 aa) |
| | G1SSE7_RABIT | Uncharacterized protein; Belongs to the peptidase C14A family. (306 aa) |
| | XRCC6 | X-ray repair cross complementing 6. (632 aa) |
| | ANKRD1 | Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (319 aa) |
| | NEDD4 | NEDD4 E3 ubiquitin protein ligase. (1315 aa) |
| | XRCC5 | X-ray repair cross complementing 5. (733 aa) |
| | PPID | Peptidylprolyl isomerase D. (369 aa) |
| | BMF | Bcl2 modifying factor. (184 aa) |
| | EIF2AK4 | Eukaryotic translation initiation factor 2 alpha kinase 4. (1651 aa) |
| | BAX | BCL2 associated X, apoptosis regulator. (192 aa) |
| | SLC12A6 | Solute carrier family 12 member 6. (1197 aa) |
| | RGR | Retinal G protein coupled receptor; Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. (295 aa) |
| | NIPBL | Nipped-B protein. (2580 aa) |
| | NOX1 | NADPH oxidase 1. (564 aa) |
| | MTPN | Myotrophin. (186 aa) |
| | HYAL1 | Hyaluronidase. (497 aa) |
| | EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa) |
| | HYAL2 | Hyaluronidase. (475 aa) |
| | PIK3R1 | Phosphoinositide-3-kinase regulatory subunit 1. (724 aa) |
| | ERRFI1 | ERBB receptor feedback inhibitor 1. (459 aa) |
| | PYCARD | PYD and CARD domain containing. (196 aa) |
| | CREBBP | CREB binding protein. (2403 aa) |
| | TRPV4 | Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (679 aa) |
| | SLC4A11 | Solute carrier family 4 member 11. (882 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1852 aa) |
| | BMP6 | Bone morphogenetic protein 6. (411 aa) |
| | BCL2L1 | Bcl-X. (233 aa) |
| | RGS9 | Regulator of G protein signaling 9. (680 aa) |
| | POLK | UmuC domain-containing protein. (385 aa) |
| | BNIP3 | BCL2 interacting protein 3. (218 aa) |
| | POLD3 | DNA polymerase delta 3, accessory subunit. (465 aa) |
| | SLC24A2 | Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (665 aa) |
| | PKD2 | Polycystin 2, transient receptor potential cation channel. (994 aa) |
| | MAP3K2 | Mitogen-activated protein kinase kinase kinase 2. (623 aa) |
| | TLR4 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa) |
| | CASP2 | Caspase 2; Belongs to the peptidase C14A family. (451 aa) |
| | DDB2 | Damage specific DNA binding protein 2. (427 aa) |
| | SDE2 | SDE2 telomere maintenance homolog. (443 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2643 aa) |
| | REST | RE1 silencing transcription factor. (930 aa) |
| | CDCA7 | Cell division cycle associated 7. (451 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
