48 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANKRD1	Ankyrin repeat domain-containing protein 1; May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). (319 aa)
	PTGER4	Prostaglandin E2 receptor EP4 subtype; Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. (488 aa)
	LTBR	Lymphotoxin beta receptor. (414 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	CASP2	Caspase 2; Belongs to the peptidase C14A family. (451 aa)
	TLR4	TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
	MAP3K2	Mitogen-activated protein kinase kinase kinase 2. (623 aa)
	BNIP3	BCL2 interacting protein 3. (218 aa)
	BMP6	Bone morphogenetic protein 6. (411 aa)
	MTPN	Myotrophin. (186 aa)
	G1SSE7_RABIT	Uncharacterized protein; Belongs to the peptidase C14A family. (306 aa)
	ENG	Endoglin. (758 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	BAG3	BCL2 associated athanogene 3. (805 aa)
	IL33	Uncharacterized protein. (142 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1464 aa)
	TLR3	TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa)
	G1TKQ0_RABIT	ANK_REP_REGION domain-containing protein. (118 aa)
	TMEM150C	Transmembrane protein 150C. (249 aa)
	CASP10	Caspase-10; Belongs to the peptidase C14A family. (469 aa)
	HABP4	HABP4_PAI-RBP1 domain-containing protein. (182 aa)
	IL1B	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
	MAG	Uncharacterized protein. (58 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (968 aa)
	PDE2A	Phosphodiesterase. (936 aa)
	BAK1	BCL2 antagonist/killer 1. (210 aa)
	TLR8	Toll like receptor 8; Belongs to the Toll-like receptor family. (1030 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1202 aa)
	SLC38A2	Solute carrier family 38 member 2. (563 aa)
	ENSOCUP00000030953	IRF tryptophan pentad repeat domain-containing protein. (200 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	RIPOR2	RHO family interacting cell polarization regulator 2. (1110 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (873 aa)
	CD40	Uncharacterized protein. (494 aa)
	MYD88	Uncharacterized protein. (476 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4. (520 aa)
	MAP3K1	Mitogen-activated protein kinase kinase kinase 1. (1408 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	F11R	F11 receptor. (314 aa)
	GHRHR	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa)
	PIEZO2	Piezo-type mechanosensitive ion channel component. (2725 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (664 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (472 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	TNFSF14	TNF superfamily member 14. (241 aa)
	IRF1	Interferon regulatory factor. (336 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAG3	TNFRSF1A	ENSOCUP00000010054	ENSOCUP00000045661	BCL2 associated athanogene 3.	TNF receptor superfamily member 1A.	0.582
BAK1	BNIP3	ENSOCUP00000026421	ENSOCUP00000002192	BCL2 antagonist/killer 1.	BCL2 interacting protein 3.	0.455
BAK1	CASP10	ENSOCUP00000026421	ENSOCUP00000020313	BCL2 antagonist/killer 1.	Caspase-10; Belongs to the peptidase C14A family.	0.465
BAK1	CASP2	ENSOCUP00000026421	ENSOCUP00000001859	BCL2 antagonist/killer 1.	Caspase 2; Belongs to the peptidase C14A family.	0.414
BNIP3	BAK1	ENSOCUP00000002192	ENSOCUP00000026421	BCL2 interacting protein 3.	BCL2 antagonist/killer 1.	0.455
BNIP3	IL1B	ENSOCUP00000002192	ENSOCUP00000021869	BCL2 interacting protein 3.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.549
BNIP3	MYD88	ENSOCUP00000002192	ENSOCUP00000034296	BCL2 interacting protein 3.	Uncharacterized protein.	0.458
BNIP3	TLR4	ENSOCUP00000002192	ENSOCUP00000001909	BCL2 interacting protein 3.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.442
CASP10	BAK1	ENSOCUP00000020313	ENSOCUP00000026421	Caspase-10; Belongs to the peptidase C14A family.	BCL2 antagonist/killer 1.	0.465
CASP10	CASP2	ENSOCUP00000020313	ENSOCUP00000001859	Caspase-10; Belongs to the peptidase C14A family.	Caspase 2; Belongs to the peptidase C14A family.	0.635
CASP10	IL1B	ENSOCUP00000020313	ENSOCUP00000021869	Caspase-10; Belongs to the peptidase C14A family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.659
CASP10	MYD88	ENSOCUP00000020313	ENSOCUP00000034296	Caspase-10; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.416
CASP10	TLR4	ENSOCUP00000020313	ENSOCUP00000001909	Caspase-10; Belongs to the peptidase C14A family.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.588
CASP10	TNFRSF1A	ENSOCUP00000020313	ENSOCUP00000045661	Caspase-10; Belongs to the peptidase C14A family.	TNF receptor superfamily member 1A.	0.581
CASP2	BAK1	ENSOCUP00000001859	ENSOCUP00000026421	Caspase 2; Belongs to the peptidase C14A family.	BCL2 antagonist/killer 1.	0.414
CASP2	CASP10	ENSOCUP00000001859	ENSOCUP00000020313	Caspase 2; Belongs to the peptidase C14A family.	Caspase-10; Belongs to the peptidase C14A family.	0.635
CASP2	G1SSE7_RABIT	ENSOCUP00000001859	ENSOCUP00000006164	Caspase 2; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.497
CASP2	IL1B	ENSOCUP00000001859	ENSOCUP00000021869	Caspase 2; Belongs to the peptidase C14A family.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.506
CASP2	TNFRSF1A	ENSOCUP00000001859	ENSOCUP00000045661	Caspase 2; Belongs to the peptidase C14A family.	TNF receptor superfamily member 1A.	0.472
CD40	IL1B	ENSOCUP00000034264	ENSOCUP00000021869	Uncharacterized protein.	Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family.	0.794