STRINGSTRING
SYT2-2 SYT2-2 EEF2K EEF2K G1SW49_RABIT G1SW49_RABIT SYT4 SYT4 CPNE9 CPNE9 MCOLN1 MCOLN1 PPIF PPIF PLCG2 PLCG2 HPCA HPCA NCSTN NCSTN SMPD1 SMPD1 GUCA1A GUCA1A ADGRV1 ADGRV1 CPNE3 CPNE3 SYT7 SYT7 ALOX15 ALOX15 CPNE5 CPNE5 WNT5A WNT5A CPNE2 CPNE2 PRKAA1 PRKAA1 PKD2 PKD2 ADCY8 ADCY8 ITPKA ITPKA HPCAL1 HPCAL1 ACER1 ACER1 MEF2A MEF2A RASGRP2 RASGRP2 SYT6 SYT6 ADD1 ADD1 FOS FOS CARF CARF DMTN DMTN ECT2 ECT2 SYT2 SYT2 RYR1 RYR1 IQGAP1 IQGAP1 U3KNC9_RABIT U3KNC9_RABIT SLC25A24 SLC25A24 SYT9 SYT9 SYT12 SYT12 NFS1 NFS1 CHP2 CHP2 ENSOCUP00000030584 ENSOCUP00000030584 RASAL1 RASAL1 CRHBP CRHBP BRAF BRAF ENSOCUP00000031759 ENSOCUP00000031759 SYT17 SYT17 GPLD1 GPLD1 CPNE8 CPNE8 CAPN3 CAPN3 ITPKB ITPKB JUN JUN SYT11 SYT11 DPEP1 DPEP1 FOSB FOSB NLGN1 NLGN1 RYR3 RYR3 CLIC4 CLIC4 MEF2C MEF2C LOC100344835 LOC100344835 CPNE4 CPNE4 LOC100351528 LOC100351528 SYT10 SYT10 PRKAA2 PRKAA2 INHBB INHBB SYT13 SYT13 LGMN LGMN CPNE6 CPNE6 ITPKC ITPKC SCN5A SCN5A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SYT2-2Uncharacterized protein. (81 aa)
EEF2KEukaryotic elongation factor 2 kinase. (725 aa)
G1SW49_RABITUncharacterized protein. (304 aa)
SYT4Synaptotagmin 4. (425 aa)
CPNE9Copine family member 9. (516 aa)
MCOLN1Mucolipin 1. (578 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (142 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1267 aa)
HPCAHippocalcin. (193 aa)
NCSTNNicastrin. (667 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (627 aa)
GUCA1AUncharacterized protein. (275 aa)
ADGRV1Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6298 aa)
CPNE3Copine 3. (534 aa)
SYT7Synaptotagmin 7. (523 aa)
ALOX15Arachidonate 15-lipoxygenase; Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12- HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the o [...] (674 aa)
CPNE5Copine 5. (610 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
CPNE2Copine 2. (644 aa)
PRKAA1Non-specific serine/threonine protein kinase. (656 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (994 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (443 aa)
HPCAL1Hippocalcin like 1. (193 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (253 aa)
MEF2AMyocyte enhancer factor 2A. (511 aa)
RASGRP2Uncharacterized protein. (296 aa)
SYT6Synaptotagmin 6. (426 aa)
ADD1Adducin 1. (622 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
CARFCalcium responsive transcription factor. (725 aa)
DMTNDematin actin binding protein. (424 aa)
ECT2Epithelial cell transforming 2. (952 aa)
SYT2Synaptotagmin 2. (286 aa)
RYR1Ryanodine receptor 1; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high- level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm (By similarity). Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. [...] (4598 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1727 aa)
U3KNC9_RABITUncharacterized protein. (382 aa)
SLC25A24Calcium-binding mitochondrial carrier protein SCaMC-1; Calcium-dependent mitochondrial solute carrier. Mediates the reversible, electroneutral exchange of Mg-ATP or Mg-ADP against phosphate ions, catalyzing the net uptake or efflux of adenine nucleotides across the mitochondrial inner membrane. Nucleotide transport is inactive when cytosolic calcium levels are low, and is activated by an increase in cytosolic calcium levels. May play a role in protecting cells against oxidative stress-induced cell death, probably by promoting the formation of calcium-phosphate precipitates in the mitoc [...] (455 aa)
SYT9Synaptotagmin 9. (538 aa)
SYT12Synaptotagmin 12. (488 aa)
NFS1C2 domain-containing protein. (997 aa)
CHP2Calcineurin like EF-hand protein 2. (229 aa)
ENSOCUP00000030584Uncharacterized protein. (513 aa)
RASAL1RAS protein activator like 1. (1200 aa)
CRHBPCorticotropin releasing hormone binding protein. (382 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (767 aa)
ENSOCUP00000031759Guanylate cyclase domain-containing protein. (312 aa)
SYT17Synaptotagmin 17. (474 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (852 aa)
CPNE8Copine 8. (594 aa)
CAPN3Uncharacterized protein; Belongs to the peptidase C2 family. (820 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (924 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
SYT11Synaptotagmin 11. (440 aa)
DPEP1Dipeptidase 1; Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (524 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (289 aa)
NLGN1Neuroligin 1. (823 aa)
RYR3Ryanodine receptor 3; Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca(2+) release by other calcium channels. Calcium channel that mediates Ca(2+)-induced Ca(2+) release from the endoplasmic reticulum in non-muscle cells. Plays a role in cellular calcium signaling. Contributes to cellular calcium ion homeostasis. Isoform 2 lacks a predicted transmembrane segment and does not form functional calcium channels by itself; however, it can form tetramers [...] (4876 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (322 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LOC100344835Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (474 aa)
CPNE4Copine 4. (576 aa)
LOC100351528Uncharacterized protein. (423 aa)
SYT10Synaptotagmin 10. (481 aa)
PRKAA2Non-specific serine/threonine protein kinase. (537 aa)
INHBBInhibin subunit beta B. (302 aa)
SYT13Synaptotagmin 13. (425 aa)
LGMNLegumain. (435 aa)
CPNE6Copine 6. (557 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (636 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1847 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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