STRINGSTRING
CCL24 CCL24 WNT5A WNT5A ACTR3B ACTR3B IRF8 IRF8 SLC26A6 SLC26A6 G1SDU7_RABIT G1SDU7_RABIT LOC100348776 LOC100348776 PDE12 PDE12 CCL20 CCL20 TP53 TP53 NOS2 NOS2 TLR4 TLR4 CCL5 CCL5 STXBP3 STXBP3 MRC1 MRC1 ACTR3 ACTR3 RPS6KB1 RPS6KB1 CX3CL1 CX3CL1 LOC100349257 LOC100349257 AQP4 AQP4 VIM VIM CLDN1 CLDN1 EPRS1 EPRS1 VPS26B VPS26B LOC100349255 LOC100349255 CCL1 CCL1 WAS WAS CCL22 CCL22 IL12B IL12B JAK2 JAK2 GBP1 GBP1 KIF5B KIF5B TLR3 TLR3 CCL2 CCL2 SYNCRIP SYNCRIP STXBP1 STXBP1 G1TN23_RABIT G1TN23_RABIT ZYX ZYX CCL14 CCL14 CCL17 CCL17 G1TSM7_RABIT G1TSM7_RABIT CCL21 CCL21 RPL13A RPL13A AIF1 AIF1 CDC42EP2 CDC42EP2 LOC100346209 LOC100346209 G1U940_RABIT G1U940_RABIT CDC42-2 CDC42-2 ENSOCUP00000027326 ENSOCUP00000027326 ASS1 ASS1 LOC100349005 LOC100349005 RAB7B RAB7B CIITA CIITA ENSOCUP00000029790 ENSOCUP00000029790 ENSOCUP00000030953 ENSOCUP00000030953 NMI NMI STXBP4 STXBP4 ENSOCUP00000031750 ENSOCUP00000031750 ENSOCUP00000034123 ENSOCUP00000034123 VAMP3 VAMP3 ENSOCUP00000035670 ENSOCUP00000035670 CCL4 CCL4 LOC100346467 LOC100346467 ACTR2 ACTR2 CCL19 CCL19 STAT1 STAT1 STX8 STX8 ENSOCUP00000039931 ENSOCUP00000039931 ENSOCUP00000040691 ENSOCUP00000040691 CCL25 CCL25 STX4 STX4 GSN GSN ENSOCUP00000042867 ENSOCUP00000042867 ACOD1 ACOD1 MYO1C MYO1C DAPK1 DAPK1 CDC42 CDC42 IRF1 IRF1 ENSOCUP00000049280 ENSOCUP00000049280 ADAMTS13 ADAMTS13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCL24SCY domain-containing protein. (113 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (418 aa)
IRF8Interferon regulatory factor 8. (455 aa)
SLC26A6Solute carrier family 26 member 6. (739 aa)
G1SDU7_RABITC-C motif chemokine. (104 aa)
LOC100348776C-C motif chemokine. (93 aa)
PDE12Phosphodiesterase 12. (610 aa)
CCL20C-C motif chemokine. (96 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
NOS2Nitric oxide synthase, inducible; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S- nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in i [...] (1146 aa)
TLR4TIR domain-containing protein; Belongs to the Toll-like receptor family. (839 aa)
CCL5C-C motif chemokine. (91 aa)
STXBP3Syntaxin binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (556 aa)
MRC1Mannose receptor C-type 1. (1455 aa)
ACTR3Uncharacterized protein; Belongs to the actin family. (418 aa)
RPS6KB1Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] (490 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
LOC100349257GB1/RHD3-type G domain-containing protein. (624 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
VIMVimentin; Belongs to the intermediate filament family. (466 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1447 aa)
VPS26BVPS26, retromer complex component B. (645 aa)
LOC100349255SCY domain-containing protein. (114 aa)
CCL1C-C motif chemokine. (190 aa)
WASWASP actin nucleation promoting factor. (527 aa)
CCL22C-C motif chemokine. (93 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
GBP1Guanylate binding protein 1. (591 aa)
KIF5BKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (921 aa)
TLR3TIR domain-containing protein; Belongs to the Toll-like receptor family. (867 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (125 aa)
SYNCRIPUncharacterized protein. (623 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (590 aa)
G1TN23_RABITSCY domain-containing protein. (116 aa)
ZYXZyxin. (572 aa)
CCL14C-C motif chemokine ligand 14. (94 aa)
CCL17SCY domain-containing protein. (106 aa)
G1TSM7_RABITUncharacterized protein. (65 aa)
CCL21C-C motif chemokine ligand 21. (131 aa)
RPL13AUncharacterized protein. (135 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CDC42EP2CDC42 effector protein 2. (215 aa)
LOC100346209GB1/RHD3-type G domain-containing protein. (645 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
CDC42-2Uncharacterized protein. (222 aa)
ENSOCUP00000027326Uncharacterized protein. (300 aa)
ASS1Uncharacterized protein. (251 aa)
LOC100349005GB1/RHD3-type G domain-containing protein. (852 aa)
RAB7BUncharacterized protein. (280 aa)
CIITAClass II major histocompatibility complex transactivator. (1175 aa)
ENSOCUP00000029790Uncharacterized protein. (160 aa)
ENSOCUP00000030953IRF tryptophan pentad repeat domain-containing protein. (200 aa)
NMIN-myc and STAT interactor. (367 aa)
STXBP4Syntaxin binding protein 4. (555 aa)
ENSOCUP00000031750Uncharacterized protein. (60 aa)
ENSOCUP00000034123Uncharacterized protein. (421 aa)
VAMP3Vesicle associated membrane protein 3. (128 aa)
ENSOCUP00000035670IG domain-containing protein. (123 aa)
CCL4C-C motif chemokine 4. (96 aa)
LOC100346467GB1/RHD3-type G domain-containing protein. (638 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (425 aa)
CCL19C-C motif chemokine. (109 aa)
STAT1Signal transducer and activator of transcription. (879 aa)
STX8t-SNARE coiled-coil homology domain-containing protein. (125 aa)
ENSOCUP00000039931GB1/RHD3-type G domain-containing protein. (98 aa)
ENSOCUP00000040691Uncharacterized protein. (65 aa)
CCL25SCY domain-containing protein. (159 aa)
STX4t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (298 aa)
GSNGelsolin. (828 aa)
ENSOCUP00000042867Uncharacterized protein. (340 aa)
ACOD1Aconitate decarboxylase 1. (499 aa)
MYO1CMyosin IC; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1000 aa)
DAPK1Death associated protein kinase 1. (1493 aa)
CDC42Uncharacterized protein. (191 aa)
IRF1Interferon regulatory factor. (336 aa)
ENSOCUP00000049280SCY domain-containing protein. (136 aa)
ADAMTS13ACR domain-containing protein. (428 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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