(14 nodes) Cellular response to fluid shear stress network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KLF4	Uncharacterized protein. (145 aa)
	ENSOCUP00000042867	Uncharacterized protein. (340 aa)
	LOC100357982	BZIP domain-containing protein. (301 aa)
	ASS1	Uncharacterized protein. (251 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (677 aa)
	HAS2	Uncharacterized protein. (556 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (604 aa)
	MAPK7	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (493 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	MTSS1	MTSS I-BAR domain containing 1. (892 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (994 aa)
	XBP1	X-box binding protein 1. (208 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASS1	ENSOCUP00000042867	ENSOCUP00000027703	ENSOCUP00000042867	Uncharacterized protein.	Uncharacterized protein.	0.945
ASS1	PTK2B	ENSOCUP00000027703	ENSOCUP00000018603	Uncharacterized protein.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.577
ENSOCUP00000042867	ASS1	ENSOCUP00000042867	ENSOCUP00000027703	Uncharacterized protein.	Uncharacterized protein.	0.945
HAS2	PTGS2	ENSOCUP00000022472	ENSOCUP00000014415	Uncharacterized protein.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.580
KLF4	MEF2C	ENSOCUP00000005117	ENSOCUP00000047636	Uncharacterized protein.	Myocyte enhancer factor 2C.	0.488
MAPK7	MEF2C	ENSOCUP00000013022	ENSOCUP00000047636	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Myocyte enhancer factor 2C.	0.717
MAPK7	NFE2L2	ENSOCUP00000013022	ENSOCUP00000026975	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Nuclear factor, erythroid 2 like 2.	0.914
MEF2C	KLF4	ENSOCUP00000047636	ENSOCUP00000005117	Myocyte enhancer factor 2C.	Uncharacterized protein.	0.488
MEF2C	MAPK7	ENSOCUP00000047636	ENSOCUP00000013022	Myocyte enhancer factor 2C.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.717
MEF2C	PTK2B	ENSOCUP00000047636	ENSOCUP00000018603	Myocyte enhancer factor 2C.	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.621
NFE2L2	MAPK7	ENSOCUP00000026975	ENSOCUP00000013022	Nuclear factor, erythroid 2 like 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.914
NFE2L2	PTGS2	ENSOCUP00000026975	ENSOCUP00000014415	Nuclear factor, erythroid 2 like 2.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.645
NFE2L2	XBP1	ENSOCUP00000026975	ENSOCUP00000005988	Nuclear factor, erythroid 2 like 2.	X-box binding protein 1.	0.441
PTGS2	HAS2	ENSOCUP00000014415	ENSOCUP00000022472	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	Uncharacterized protein.	0.580
PTGS2	NFE2L2	ENSOCUP00000014415	ENSOCUP00000026975	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	Nuclear factor, erythroid 2 like 2.	0.645
PTK2B	ASS1	ENSOCUP00000018603	ENSOCUP00000027703	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Uncharacterized protein.	0.577
PTK2B	MEF2C	ENSOCUP00000018603	ENSOCUP00000047636	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Myocyte enhancer factor 2C.	0.621
XBP1	NFE2L2	ENSOCUP00000005988	ENSOCUP00000026975	X-box binding protein 1.	Nuclear factor, erythroid 2 like 2.	0.441