29 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

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protein homology

Your Input:
	SMYD3	SET and MYND domain containing 3. (428 aa)
	GJB2	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (226 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (459 aa)
	RPS6KB1	Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...] (490 aa)
	USP8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1088 aa)
	GDNF	Glial cell derived neurotrophic factor. (159 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	SERPINF1	Serpin family F member 1; Belongs to the serpin family. (418 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ENSOCUP00000042867	Uncharacterized protein. (340 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	METTL21C	Methyltransferase like 21C. (331 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	FBXO32	F-box protein 32. (364 aa)
	GHRHR	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (524 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	TFAP4	Transcription factor AP-4. (585 aa)
	ENSOCUP00000027928	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (88 aa)
	ASS1	Uncharacterized protein. (251 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (466 aa)
	AXIN2	Axin 2. (816 aa)
	MSTN	Myostatin. (375 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1464 aa)
	DDIT4	DNA damage inducible transcript 4. (229 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	SRD5A1	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASS1	ENSOCUP00000042867	ENSOCUP00000027703	ENSOCUP00000042867	Uncharacterized protein.	Uncharacterized protein.	0.945
CASP9	DDIT4	ENSOCUP00000047129	ENSOCUP00000014411	Caspase 9; Belongs to the peptidase C14A family.	DNA damage inducible transcript 4.	0.429
CASP9	IGF1R	ENSOCUP00000047129	ENSOCUP00000012731	Caspase 9; Belongs to the peptidase C14A family.	Tyrosine-protein kinase receptor.	0.457
CASP9	JAK2	ENSOCUP00000047129	ENSOCUP00000014491	Caspase 9; Belongs to the peptidase C14A family.	Tyrosine-protein kinase.	0.594
DDIT4	CASP9	ENSOCUP00000014411	ENSOCUP00000047129	DNA damage inducible transcript 4.	Caspase 9; Belongs to the peptidase C14A family.	0.429
ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000037329	JAK2	ENSOCUP00000037329	ENSOCUP00000014491	TGFb_propeptide domain-containing protein.	Tyrosine-protein kinase.	0.410
ENSOCUP00000037329	LOC103345451	ENSOCUP00000037329	ENSOCUP00000031740	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.419
ENSOCUP00000042867	ASS1	ENSOCUP00000042867	ENSOCUP00000027703	Uncharacterized protein.	Uncharacterized protein.	0.945
ENSOCUP00000044284	ENSOCUP00000037329	ENSOCUP00000044284	ENSOCUP00000037329	TGFb_propeptide domain-containing protein.	TGFb_propeptide domain-containing protein.	0.412
ENSOCUP00000044284	JAK2	ENSOCUP00000044284	ENSOCUP00000014491	TGFb_propeptide domain-containing protein.	Tyrosine-protein kinase.	0.410
FBXO32	MSTN	ENSOCUP00000039319	ENSOCUP00000010893	F-box protein 32.	Myostatin.	0.710
GDNF	JAK2	ENSOCUP00000002636	ENSOCUP00000014491	Glial cell derived neurotrophic factor.	Tyrosine-protein kinase.	0.421
IGF1R	CASP9	ENSOCUP00000012731	ENSOCUP00000047129	Tyrosine-protein kinase receptor.	Caspase 9; Belongs to the peptidase C14A family.	0.457
IGF1R	JAK2	ENSOCUP00000012731	ENSOCUP00000014491	Tyrosine-protein kinase receptor.	Tyrosine-protein kinase.	0.513
IGF1R	MSTN	ENSOCUP00000012731	ENSOCUP00000010893	Tyrosine-protein kinase receptor.	Myostatin.	0.470
IGF1R	RPS6KB1	ENSOCUP00000012731	ENSOCUP00000003969	Tyrosine-protein kinase receptor.	Ribosomal protein S6 kinase beta-1; Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTO [...]	0.613
JAK2	CASP9	ENSOCUP00000014491	ENSOCUP00000047129	Tyrosine-protein kinase.	Caspase 9; Belongs to the peptidase C14A family.	0.594
JAK2	ENSOCUP00000037329	ENSOCUP00000014491	ENSOCUP00000037329	Tyrosine-protein kinase.	TGFb_propeptide domain-containing protein.	0.410
JAK2	ENSOCUP00000044284	ENSOCUP00000014491	ENSOCUP00000044284	Tyrosine-protein kinase.	TGFb_propeptide domain-containing protein.	0.410