54 items (Oryctolagus cuniculus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ANO6	Anoctamin. (1003 aa)
	WNT5A	Protein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
	PLA2G7	Platelet-activating factor acetylhydrolase. (423 aa)
	CCL20	C-C motif chemokine. (96 aa)
	CCL27	Uncharacterized protein. (257 aa)
	S100A14	S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
	CCL5	C-C motif chemokine. (91 aa)
	DOCK8	Dedicator of cytokinesis 8; Belongs to the DOCK family. (2102 aa)
	CCR1	Chemokine receptor; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	TMEM102	Transmembrane protein 102. (510 aa)
	PYCARD	PYD and CARD domain containing. (196 aa)
	LGMN	Legumain. (435 aa)
	G1SV95_RABIT	Transforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
	ABL2	Tyrosine-protein kinase. (1146 aa)
	DEFB124	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (71 aa)
	ADAM17	ADAM metallopeptidase domain 17. (827 aa)
	APP	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...] (769 aa)
	LOC100349255	SCY domain-containing protein. (114 aa)
	CCL1	C-C motif chemokine. (190 aa)
	NEDD9	Neural precursor cell expressed, developmentally down-regulated 9. (828 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (362 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	CD99L2	CD99 molecule like 2. (267 aa)
	STK39	Serine/threonine kinase 39. (544 aa)
	CORO1A	Coronin; Belongs to the WD repeat coronin family. (441 aa)
	TNFSF18	TNF superfamily member 18. (217 aa)
	AGER	Advanced glycosylation end-product specific receptor. (401 aa)
	CCR7	C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
	CXCL13	C-X-C motif chemokine ligand 13. (105 aa)
	CXCL17	C-X-C motif chemokine ligand 17. (122 aa)
	CCL21	C-C motif chemokine ligand 21. (131 aa)
	AIF1	Allograft inflammatory factor 1. (147 aa)
	ITGA4	Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1031 aa)
	CCR6	C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
	SLAMF1	Signaling lymphocytic activation molecule family member 1. (340 aa)
	JAM2	Junctional adhesion molecule 2. (297 aa)
	G1U9D6_RABIT	Uncharacterized protein. (105 aa)
	MADCAM1	Uncharacterized protein. (344 aa)
	LOC103345451	TGFb_propeptide domain-containing protein. (203 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (873 aa)
	CREB3	cAMP responsive element binding protein 3. (377 aa)
	WNK1	WNK lysine deficient protein kinase 1. (2853 aa)
	MOSPD2	Motile sperm domain containing 2. (556 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
	ENSOCUP00000037329	TGFb_propeptide domain-containing protein. (263 aa)
	ADAM10	ADAM metallopeptidase domain 10. (748 aa)
	ABL1	Tyrosine-protein kinase. (1118 aa)
	ENSOCUP00000041840	TGFb_propeptide domain-containing protein. (219 aa)
	ENSOCUP00000044284	TGFb_propeptide domain-containing protein. (260 aa)
	ADAM8	ADAM metallopeptidase domain 8. (978 aa)
	ENSOCUP00000045925	TGFb_propeptide domain-containing protein. (272 aa)
	TNFSF14	TNF superfamily member 14. (241 aa)
	SELENOK	Uncharacterized protein. (93 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ABL2	ENSOCUP00000038489	ENSOCUP00000007546	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
ABL2	ABL1	ENSOCUP00000007546	ENSOCUP00000038489	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.907
ADAM10	ADAM17	ENSOCUP00000037667	ENSOCUP00000009023	ADAM metallopeptidase domain 10.	ADAM metallopeptidase domain 17.	0.943
ADAM10	APP	ENSOCUP00000037667	ENSOCUP00000009130	ADAM metallopeptidase domain 10.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.890
ADAM17	ADAM10	ENSOCUP00000009023	ENSOCUP00000037667	ADAM metallopeptidase domain 17.	ADAM metallopeptidase domain 10.	0.943
ADAM17	APP	ENSOCUP00000009023	ENSOCUP00000009130	ADAM metallopeptidase domain 17.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.748
AGER	APP	ENSOCUP00000017209	ENSOCUP00000009130	Advanced glycosylation end-product specific receptor.	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	0.646
AIF1	CCR1	ENSOCUP00000021741	ENSOCUP00000003170	Allograft inflammatory factor 1.	Chemokine receptor; Belongs to the G-protein coupled receptor 1 family.	0.405
AIF1	PYCARD	ENSOCUP00000021741	ENSOCUP00000003881	Allograft inflammatory factor 1.	PYD and CARD domain containing.	0.489
APP	ADAM10	ENSOCUP00000009130	ENSOCUP00000037667	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	ADAM metallopeptidase domain 10.	0.890
APP	ADAM17	ENSOCUP00000009130	ENSOCUP00000009023	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	ADAM metallopeptidase domain 17.	0.748
APP	AGER	ENSOCUP00000009130	ENSOCUP00000017209	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	Advanced glycosylation end-product specific receptor.	0.646
APP	ENSOCUP00000037329	ENSOCUP00000009130	ENSOCUP00000037329	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	TGFb_propeptide domain-containing protein.	0.407
APP	ENSOCUP00000044284	ENSOCUP00000009130	ENSOCUP00000044284	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	TGFb_propeptide domain-containing protein.	0.407
APP	LOC103345451	ENSOCUP00000009130	ENSOCUP00000031740	Gamma-secretase C-terminal fragment 57; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis-inducing pathways such as those medi [...]	TGFb_propeptide domain-containing protein.	0.407
CCL1	CCL20	ENSOCUP00000011541	ENSOCUP00000000754	C-C motif chemokine.	C-C motif chemokine.	0.748
CCL1	CCL21	ENSOCUP00000011541	ENSOCUP00000020728	C-C motif chemokine.	C-C motif chemokine ligand 21.	0.646
CCL1	CCL27	ENSOCUP00000011541	ENSOCUP00000001060	C-C motif chemokine.	Uncharacterized protein.	0.784
CCL1	CCL5	ENSOCUP00000011541	ENSOCUP00000002470	C-C motif chemokine.	C-C motif chemokine.	0.841
CCL1	CCR1	ENSOCUP00000011541	ENSOCUP00000003170	C-C motif chemokine.	Chemokine receptor; Belongs to the G-protein coupled receptor 1 family.	0.943