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GDF6 GDF6 G1SV95_RABIT G1SV95_RABIT RBPMS RBPMS NODAL NODAL SNW1 SNW1 CDH5 CDH5 INHBA INHBA BMP3 BMP3 KIAA0319 KIAA0319 GPC3 GPC3 NUP93 NUP93 GATA4 GATA4 ACVR1 ACVR1 SULF1 SULF1 BMP10 BMP10 BMP2 BMP2 ADAM17 ADAM17 GDF5 GDF5 BMP4 BMP4 SMAD2 SMAD2 ING2 ING2 CDKN2B CDKN2B MSTN MSTN CITED2 CITED2 ILK ILK ITGA8 ITGA8 ENSOCUP00000045925 ENSOCUP00000045925 DAB2 DAB2 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000041840 ENSOCUP00000041840 RNF111 RNF111 NEO1 NEO1 ENSOCUP00000037329 ENSOCUP00000037329 BMPR2 BMPR2 ENSOCUP00000036387 ENSOCUP00000036387 ENSOCUP00000036340 ENSOCUP00000036340 NOTCH2 NOTCH2 TGFBR1 TGFBR1 ZNF423 ZNF423 LOC103345451 LOC103345451 C4H20orf27 C4H20orf27 GDF2 GDF2 GDF3 GDF3 HFE HFE HSP90AB1 HSP90AB1 SCUBE3 SCUBE3 TGFBR3 TGFBR3 SDCBP SDCBP ACVR2A ACVR2A GIPC2 GIPC2 JAK2 JAK2 BMPR1A BMPR1A TWSG1 TWSG1 FLCN FLCN PARP1 PARP1 ACVR1B ACVR1B ZEB2 ZEB2 SOX11 SOX11 ACVRL1 ACVRL1 FERMT1 FERMT1 LOC100341360 LOC100341360 GDF7 GDF7 KCP KCP BMP5 BMP5 SLC2A10 SLC2A10 BMP15 BMP15 LOC100101568 LOC100101568 PELO PELO HES1 HES1 BMP7 BMP7 G1TYB9_RABIT G1TYB9_RABIT GDF11 GDF11 MYOCD MYOCD UBE2O UBE2O NUMA1 NUMA1 RNF165 RNF165 CITED1 CITED1 TBX20 TBX20 TGFBR2 TGFBR2 INHA INHA TGFB3 TGFB3 EP300 EP300 BMP6 BMP6 THBS1 THBS1 CCN1 CCN1 SMAD4 SMAD4 GDF10 GDF10 CREBBP CREBBP KDR KDR INHBB INHBB TGFB2 TGFB2 FBXL15 FBXL15 ENG ENG KIAA1324L KIAA1324L INHBC INHBC INHBE INHBE BMP8B BMP8B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF6Growth differentiation factor 6. (427 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
RBPMSRNA binding protein, mRNA processing factor. (219 aa)
NODALNodal growth differentiation factor. (348 aa)
SNW1SNW domain containing 1. (536 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (974 aa)
INHBAInhibin subunit beta A. (424 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
KIAA0319KIAA0319. (1139 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
NUP93Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
GATA4GATA binding protein 4. (444 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SULF1Sulfatase 1. (846 aa)
BMP10Bone morphogenetic protein 10. (428 aa)
BMP2Bone morphogenetic protein 2; Induces cartilage and bone formation. Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3- EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. (271 aa)
ADAM17ADAM metallopeptidase domain 17. (827 aa)
GDF5Growth differentiation factor 5 preproprotein (Predicted). (500 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ING2Inhibitor of growth protein. (283 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
MSTNMyostatin. (375 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (249 aa)
ILKIntegrin linked kinase. (510 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1100 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
DAB2DAB adaptor protein 2. (769 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
RNF111Ring finger protein 111. (993 aa)
NEO1Neogenin 1. (1424 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1060 aa)
ENSOCUP00000036387DIX domain-containing protein. (575 aa)
ENSOCUP00000036340EGF-like domain-containing protein. (81 aa)
NOTCH2Notch receptor 2. (2481 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
ZNF423Zinc finger protein 423. (1421 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
C4H20orf27Uncharacterized protein. (386 aa)
GDF2Growth differentiation factor 2. (434 aa)
GDF3Growth differentiation factor 3. (365 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (356 aa)
HSP90AB1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (726 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (1027 aa)
TGFBR3Transforming growth factor beta receptor 3. (851 aa)
SDCBPSyndecan binding protein. (312 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (556 aa)
GIPC2GIPC PDZ domain containing family member 2. (259 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
FLCNFolliculin. (579 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (474 aa)
ZEB2Zinc finger E-box binding homeobox 2. (1188 aa)
SOX11Transcription factor SOX. (446 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (327 aa)
FERMT1Fermitin family member 1. (694 aa)
LOC100341360TGF_BETA_2 domain-containing protein. (566 aa)
GDF7Growth differentiation factor 7. (546 aa)
KCPKielin cysteine rich BMP regulator. (1203 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (483 aa)
BMP15TGF_BETA_2 domain-containing protein. (393 aa)
LOC100101568Left-right determination factor. (368 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
BMP7TGF_BETA_2 domain-containing protein. (170 aa)
G1TYB9_RABITTGF_BETA_2 domain-containing protein. (358 aa)
GDF11Growth differentiation factor 11. (395 aa)
MYOCDMyocardin. (989 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1446 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2116 aa)
RNF165Ring finger protein 165. (364 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (360 aa)
TBX20T-box transcription factor 20. (460 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
EP300E1A binding protein p300. (2418 aa)
BMP6Bone morphogenetic protein 6. (411 aa)
THBS1Thrombospondin 1. (1171 aa)
CCN1Cellular communication network factor 1. (386 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
CREBBPCREB binding protein. (2403 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
INHBBInhibin subunit beta B. (302 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
ENGEndoglin. (758 aa)
KIAA1324LKIAA1324 like. (1020 aa)
INHBCInhibin subunit beta C. (351 aa)
INHBEInhibin subunit beta E. (352 aa)
BMP8BTGF_BETA_2 domain-containing protein. (374 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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