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PSEN1 PSEN1 HFE HFE PAWR PAWR SLC7A2 SLC7A2 KCNK9 KCNK9 CACNA1D CACNA1D ENSOCUP00000031621 ENSOCUP00000031621 LOC100359182 LOC100359182 CD36 CD36 ATP1B2 ATP1B2 SLC12A5 SLC12A5 KCNJ5 KCNJ5 KCNJ3 KCNJ3 SLC19A1 SLC19A1 SLC12A2 SLC12A2 ENSOCUP00000030127 ENSOCUP00000030127 KCNJ15 KCNJ15 SLC6A1 SLC6A1 SLC1A1 SLC1A1 SLC1A3 SLC1A3 LRRC8A LRRC8A SLC3A2 SLC3A2 TRPV5 TRPV5 SLC46A1 SLC46A1 KCNJ8 KCNJ8 ARL6IP5 ARL6IP5 SCNN1B SCNN1B FAM155B FAM155B SLC39A14 SLC39A14 KCNJ14 KCNJ14 SLC16A2 SLC16A2 SLC15A2 SLC15A2 SLC6A6 SLC6A6 SLC24A2 SLC24A2 SLC6A5 SLC6A5 SLC1A2 SLC1A2 SLC39A6 SLC39A6 ATP1B3 ATP1B3 SLC12A6 SLC12A6 SLC12A4 SLC12A4 TRPV6 TRPV6 KCNJ13 KCNJ13 KCNJ16 KCNJ16 ATP1A4 ATP1A4 SLC7A11 SLC7A11 SLC9A1 SLC9A1 IRK2 IRK2 FOLR2 FOLR2 CACNA2D1 CACNA2D1 FAM155A FAM155A SLC9A9 SLC9A9 KCNJ9 KCNJ9 SLC36A1 SLC36A1 SLC39A5 SLC39A5 SLC6A20 SLC6A20 ENSOCUP00000032183 ENSOCUP00000032183 GFAP GFAP TSPO2 TSPO2 CLN8 CLN8 KCNE2 KCNE2 ATP1A1 ATP1A1 SLC15A4 SLC15A4 SLC27A5 SLC27A5 ATP1A2 ATP1A2 SLC8A1 SLC8A1 STEAP2 STEAP2 SLC5A6 SLC5A6 LRRC8E LRRC8E SLC12A3 SLC12A3 SLC39A10 SLC39A10 U3KNC9_RABIT U3KNC9_RABIT SLC2A1 SLC2A1 CNGA3 CNGA3 SLC9C1 SLC9C1 SLC9A5 SLC9A5 KCNJ4 KCNJ4 KCNJ2 KCNJ2 SLC7A3 SLC7A3 LRRC8C LRRC8C G1T017_RABIT G1T017_RABIT LRP2 LRP2 KCNJ10 KCNJ10 SLC15A1 SLC15A1 TRPV3 TRPV3 TRPV1 TRPV1 SLC9A6 SLC9A6 SLC1A6 SLC1A6 KCNJ1 KCNJ1 STEAP3 STEAP3 HCN4 HCN4 SLC12A8 SLC12A8 SCNN1A SCNN1A KCNH2 KCNH2 G1TNN7_RABIT G1TNN7_RABIT SLC39A8 SLC39A8 SLC9A7 SLC9A7 TRPV4 TRPV4 G1SLQ5_RABIT G1SLQ5_RABIT CACNA1F CACNA1F TRPV2 TRPV2 SLC9A4 SLC9A4 SLC7A1 SLC7A1 SLC9A3 SLC9A3 SLC8A3 SLC8A3 ATP1A3 ATP1A3 SLC7A8 SLC7A8 SLC6A9 SLC6A9 SLC2A10 SLC2A10 SLC5A1 SLC5A1 SLC15A3 SLC15A3 SLC24A4 SLC24A4 SLC9C2 SLC9C2 SLC6A14 SLC6A14
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (557 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (356 aa)
PAWRPro-apoptotic WT1 regulator. (339 aa)
SLC7A2Solute carrier family 7 member 2. (757 aa)
KCNK9Potassium two pore domain channel subfamily K member 9; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (477 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2141 aa)
ENSOCUP00000031621Uncharacterized protein. (1225 aa)
LOC100359182Amino acid transporter. (665 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta-2; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known (By similarity). (290 aa)
SLC12A5Solute carrier family 12 member 5. (1015 aa)
KCNJ5Potassium voltage-gated channel subfamily J member 5. (463 aa)
KCNJ3Potassium voltage-gated channel subfamily J member 3. (501 aa)
SLC19A1Solute carrier family 19 member 1. (557 aa)
SLC12A2Solute carrier family 12 member 2. (1127 aa)
ENSOCUP00000030127Uncharacterized protein. (265 aa)
KCNJ15Potassium voltage-gated channel subfamily J member 15. (415 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (254 aa)
SLC1A1Excitatory amino acid transporter 3; Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine (By similarity). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspar [...] (524 aa)
SLC1A3Amino acid transporter. (542 aa)
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (769 aa)
SLC3A24F2 cell-surface antigen heavy chain; Component of several heterodimeric amino acid transporter complexes. The precise substrate specificity depends on the other subunit in the heterodimer (By similarity). The heterodimer with SLC3A2 functions as sodium-independent, high-affinity transporter that mediates uptake of large neutral amino acids such as phenylalanine, tyrosine, L-DOPA, leucine, histidine, methionine and tryptophan. The complexes with SLC7A6 and SLC7A7 mediate uptake of dibasic amino acids. The complexes function as amino acid exchangers. Required for targeting of SLC7A5 and [...] (571 aa)
TRPV5Transient receptor potential cation channel subfamily V member 5; Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric con [...] (730 aa)
SLC46A1MFS domain-containing protein. (473 aa)
KCNJ8Inward rectifier potassium channel 6.1. (424 aa)
ARL6IP5PRA1 family protein. (188 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception; Belongs to the amiloride-sensit [...] (641 aa)
FAM155BFamily with sequence similarity 155 member B. (466 aa)
SLC39A14Solute carrier family 39 member 14. (611 aa)
KCNJ14Potassium voltage-gated channel subfamily J member 14. (434 aa)
SLC16A2Solute carrier family 16 member 2. (539 aa)
SLC15A2Solute carrier family 15 member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Can also transport the aminocephalosporin antibiotic cefadroxil ; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (729 aa)
SLC6A6Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (675 aa)
SLC24A2Solute carrier family 24 member 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (665 aa)
SLC6A5Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (797 aa)
SLC1A2Amino acid transporter. (579 aa)
SLC39A6Solute carrier family 39 member 6. (730 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta-3; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity); Belongs to the X(+)/potassium ATPases subunit beta family. (274 aa)
SLC12A6Solute carrier family 12 member 6. (1197 aa)
SLC12A4Solute carrier family 12 member 4; Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia; Belongs to the SLC12A transporter family. (1085 aa)
TRPV6ANK_REP_REGION domain-containing protein; Belongs to the transient receptor (TC 1.A.4) family. (699 aa)
KCNJ13Potassium voltage-gated channel subfamily J member 13. (360 aa)
KCNJ16Potassium voltage-gated channel subfamily J member 16. (419 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
SLC7A11Solute carrier family 7 member 11. (502 aa)
SLC9A1Sodium/hydrogen exchanger 1; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
IRK2Uncharacterized protein. (398 aa)
FOLR2Folate_rec domain-containing protein. (305 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1; The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation- contraction coupling. (1061 aa)
FAM155AFamily with sequence similarity 155 member A. (296 aa)
SLC9A9Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (644 aa)
KCNJ9Potassium voltage-gated channel subfamily J member 9. (283 aa)
SLC36A1Aa_trans domain-containing protein. (501 aa)
SLC39A5Solute carrier family 39 member 5. (549 aa)
SLC6A20Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (592 aa)
ENSOCUP00000032183Uncharacterized protein. (349 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (515 aa)
TSPO2Translocator protein 2. (205 aa)
CLN8CLN8 transmembrane ER and ERGIC protein. (288 aa)
KCNE2Potassium voltage-gated channel subfamily E member 2; Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-t [...] (123 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha-1; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity). May contribute to blood-heart barrier properties of endocardial endothelium and may control cardiac performance via endothelial Na(+)/H(+) exchange. (956 aa)
SLC15A4Solute carrier family 15 member 4. (399 aa)
SLC27A5Solute carrier family 27 member 5. (680 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1019 aa)
SLC8A1J domain-containing protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
STEAP2Uncharacterized protein. (470 aa)
SLC5A6Sodium-dependent multivitamin transporter; Transports pantothenate, biotin and lipoate in the presence of sodium; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (680 aa)
LRRC8ELeucine rich repeat containing 8 VRAC subunit E. (827 aa)
SLC12A3Uncharacterized protein. (1027 aa)
SLC39A10Solute carrier family 39 member 10. (832 aa)
U3KNC9_RABITUncharacterized protein. (382 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. (512 aa)
CNGA3Cyclic nucleotide gated channel subunit alpha 3. (691 aa)
SLC9C1Solute carrier family 9 member C1. (1151 aa)
SLC9A5Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (895 aa)
KCNJ4Potassium voltage-gated channel subfamily J member 4. (442 aa)
KCNJ2Inward rectifier potassium channel 2; Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be bl [...] (427 aa)
SLC7A3Solute carrier family 7 member 3. (594 aa)
LRRC8CLeucine rich repeat containing 8 VRAC subunit C. (803 aa)
G1T017_RABITAmino acid transporter. (234 aa)
LRP2Uncharacterized protein. (2726 aa)
KCNJ10Potassium voltage-gated channel subfamily J member 10. (564 aa)
SLC15A1Solute carrier family 15 member 1; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products. (700 aa)
TRPV3Transient receptor potential cation channel subfamily V member 3. (768 aa)
TRPV1Transient receptor potential cation channel subfamily V member 1; Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Ac [...] (842 aa)
SLC9A6Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (701 aa)
SLC1A6Amino acid transporter. (564 aa)
KCNJ1Potassium voltage-gated channel subfamily J member 1. (391 aa)
STEAP3STEAP3 metalloreductase. (498 aa)
HCN4Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4; Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. (913 aa)
SLC12A8Solute carrier family 12 member 8. (710 aa)
SCNN1AAmiloride-sensitive sodium channel subunit alpha; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. (491 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity). (1108 aa)
G1TNN7_RABITUncharacterized protein. (571 aa)
SLC39A8Solute carrier family 39 member 8. (437 aa)
SLC9A7Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (726 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (679 aa)
G1SLQ5_RABITAA_permease_C domain-containing protein. (635 aa)
CACNA1FCalcium voltage-gated channel subunit alpha1 F. (1734 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2. (817 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (803 aa)
SLC7A1Solute carrier family 7 member 1. (646 aa)
SLC9A3Sodium/hydrogen exchanger 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. (813 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (958 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (964 aa)
SLC7A8Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] (535 aa)
SLC6A9Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (652 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (483 aa)
SLC5A1Sodium/glucose cotransporter 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. (662 aa)
SLC15A3Solute carrier family 15 member 3. (575 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (613 aa)
SLC9C2Solute carrier family 9 member C2 (putative). (1113 aa)
SLC6A14Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (637 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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