node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACVR1B | ACVR1C | ENSOCUP00000015408 | ENSOCUP00000007947 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.977 |
ACVR1B | NODAL | ENSOCUP00000015408 | ENSOCUP00000007498 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Nodal growth differentiation factor. | 0.971 |
ACVR1B | SMURF2 | ENSOCUP00000015408 | ENSOCUP00000010996 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase. | 0.665 |
ACVR1C | ACVR1B | ENSOCUP00000007947 | ENSOCUP00000015408 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.977 |
ACVR1C | NODAL | ENSOCUP00000007947 | ENSOCUP00000007498 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | Nodal growth differentiation factor. | 0.959 |
ACVR1C | SMURF2 | ENSOCUP00000007947 | ENSOCUP00000010996 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | E3 ubiquitin-protein ligase. | 0.620 |
GJA1 | SMURF2 | ENSOCUP00000019547 | ENSOCUP00000010996 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] | E3 ubiquitin-protein ligase. | 0.434 |
GJA1 | TIMP1 | ENSOCUP00000019547 | ENSOCUP00000009228 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | 0.509 |
NODAL | ACVR1B | ENSOCUP00000007498 | ENSOCUP00000015408 | Nodal growth differentiation factor. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.971 |
NODAL | ACVR1C | ENSOCUP00000007498 | ENSOCUP00000007947 | Nodal growth differentiation factor. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.959 |
SMURF2 | ACVR1B | ENSOCUP00000010996 | ENSOCUP00000015408 | E3 ubiquitin-protein ligase. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.665 |
SMURF2 | ACVR1C | ENSOCUP00000010996 | ENSOCUP00000007947 | E3 ubiquitin-protein ligase. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. | 0.620 |
SMURF2 | GJA1 | ENSOCUP00000010996 | ENSOCUP00000019547 | E3 ubiquitin-protein ligase. | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] | 0.434 |
TIMP1 | GJA1 | ENSOCUP00000009228 | ENSOCUP00000019547 | Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] | 0.509 |