STRINGSTRING
ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000041840 ENSOCUP00000041840 HIF1A HIF1A JUN JUN FOSL1 FOSL1 ENSOCUP00000037329 ENSOCUP00000037329 TGFB2 TGFB2 WT1 WT1 SMAD6 SMAD6 TNF TNF NGFR NGFR EGR1 EGR1 G1SV95_RABIT G1SV95_RABIT GNL3 GNL3 STAT3 STAT3 BMP4 BMP4 LOC103345451 LOC103345451 SMARCA4 SMARCA4 SMAD1 SMAD1 KLF5 KLF5 MRTFB MRTFB BMPR1A BMPR1A GATA3 GATA3 APLN APLN SREBF2 SREBF2 FOS FOS MRTFA MRTFA MYOCD MYOCD ETS1 ETS1 G1U940_RABIT G1U940_RABIT MKL1 MKL1 SMAD3 SMAD3 PDGFB PDGFB TEAD1 TEAD1 TP53 TP53 PRL PRL SRF SRF ATOH8 ATOH8 SMAD4 SMAD4 ENSOCUP00000045925 ENSOCUP00000045925
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
HIF1AUncharacterized protein. (851 aa)
JUNBZIP domain-containing protein; Belongs to the bZIP family. (352 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (335 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
WT1WT1 transcription factor. (302 aa)
SMAD6MH2 domain-containing protein. (220 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
NGFRNerve growth factor receptor. (407 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (700 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
GNL3G protein nucleolar 3. (545 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1653 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
KLF5Uncharacterized protein. (457 aa)
MRTFBMyocardin related transcription factor B. (1103 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GATA3GATA binding protein 3. (444 aa)
APLNApelin. (77 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1137 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MRTFAMyocardin related transcription factor A. (649 aa)
MYOCDMyocardin. (989 aa)
ETS1Uncharacterized protein. (533 aa)
G1U940_RABITCellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (178 aa)
MKL1Uncharacterized protein. (84 aa)
SMAD3SMAD family member 3. (230 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (272 aa)
TEAD1TEA domain transcription factor 1. (493 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (391 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (262 aa)
SRFSerum response factor. (685 aa)
ATOH8Atonal bHLH transcription factor 8. (369 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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