STRINGSTRING
C11orf65 C11orf65 LYPD1 LYPD1 ASTN2 ASTN2 PPM1F PPM1F COMMD1 COMMD1 CLTCL1 CLTCL1 BARD1 BARD1 ARF6 ARF6 REST REST NR1H3 NR1H3 CD36 CD36 FAM3D FAM3D TERF1 TERF1 PKDCC PKDCC RAB11FIP3 RAB11FIP3 BCL2L1 BCL2L1 DCLK3 DCLK3 ITGB1BP1 ITGB1BP1 HECTD1 HECTD1 PSMD9 PSMD9 RAB11FIP1 RAB11FIP1 NDUFAF2 NDUFAF2 PTPN11 PTPN11 AP2M1 AP2M1 DERL2 DERL2 RAB23 RAB23 INHBB INHBB UBE2J1 UBE2J1 JAGN1 JAGN1 MAP1A MAP1A GDI2 GDI2 TMBIM1 TMBIM1 ERP29 ERP29 CTNNA1 CTNNA1 LRRK2 LRRK2 TMEM59 TMEM59 MTNR1B MTNR1B CABP1 CABP1 G1SV95_RABIT G1SV95_RABIT LZTS2 LZTS2 NF1 NF1 ACVR1C ACVR1C FBXO4 FBXO4 TMEM98 TMEM98 TP53INP2 TP53INP2 SYT4 SYT4 KLF7 KLF7 ILRUN ILRUN PKIG PKIG LZTFL1 LZTFL1 VPS35 VPS35 CCN3 CCN3 NUMB NUMB WWP2 WWP2 TTBK2 TTBK2 SERGEF SERGEF LATS1 LATS1 SRCIN1 SRCIN1 LATS2 LATS2 PID1 PID1 ACTN2 ACTN2 ANGPT1 ANGPT1 ANKRD13A ANKRD13A ENSOCUP00000045925 ENSOCUP00000045925 PPP3CA PPP3CA DAB2 DAB2 ENSOCUP00000044284 ENSOCUP00000044284 ENSOCUP00000043938 ENSOCUP00000043938 CLTC CLTC ENSOCUP00000042868 ENSOCUP00000042868 SNX3 SNX3 ENSOCUP00000041840 ENSOCUP00000041840 SVIP SVIP CORO2B CORO2B PARK7 PARK7 ENSOCUP00000039179 ENSOCUP00000039179 HADH HADH RHBDF2 RHBDF2 RAB11FIP5 RAB11FIP5 FRMD4A FRMD4A ENSOCUP00000037329 ENSOCUP00000037329 PPP2R5A PPP2R5A IL12A IL12A POLR1A POLR1A RHOQ RHOQ GSK3B GSK3B SIN3A SIN3A SUMO1 SUMO1 UBE2G2 UBE2G2 ADTRP ADTRP RIPOR2 RIPOR2 LOC103345451 LOC103345451 CLDN18 CLDN18 OPRM1 OPRM1 INPP5K INPP5K ENSOCUP00000031187 ENSOCUP00000031187 DCLK1 DCLK1 ENSOCUP00000030650 ENSOCUP00000030650 UBXN2B UBXN2B ENSOCUP00000029917 ENSOCUP00000029917 GHRL GHRL GOPC GOPC ABHD17B ABHD17B MACROH2A1 MACROH2A1 NDFIP1 NDFIP1 U3KN82_RABIT U3KN82_RABIT SIAH3 SIAH3 TRIM29 TRIM29 RHBDF1 RHBDF1 MAGED1 MAGED1 G1U8W6_RABIT G1U8W6_RABIT ERLEC1 ERLEC1 DRD3 DRD3 G1U7N5_RABIT G1U7N5_RABIT SAPCD2 SAPCD2 G1U4L1_RABIT G1U4L1_RABIT TAX1BP3 TAX1BP3 DERL3 DERL3 SNX33 SNX33 OS9 OS9 LEPROT LEPROT MFHAS1 MFHAS1 CDK5 CDK5 MTNR1A MTNR1A VSNL1 VSNL1 MRAP2 MRAP2 G1TZT2_RABIT G1TZT2_RABIT ROCK2 ROCK2 PARK2 PARK2 DMTN DMTN MRAP MRAP ADIPOQ ADIPOQ INS INS F2R F2R G1TSW1_RABIT G1TSW1_RABIT CHGA CHGA RANGAP1 RANGAP1 PKIA PKIA FERMT1 FERMT1 BTF3 BTF3 KCNB1 KCNB1 APOD APOD G1TG12_RABIT G1TG12_RABIT CDT1 CDT1 FLCN FLCN GDI1 GDI1 HMGCR HMGCR ABI3 ABI3 IL12B IL12B DPH3 DPH3 TRIM40 TRIM40 BAG4 BAG4 SNX12 SNX12 FOXO1 FOXO1 YOD1 YOD1 ABCC8 ABCC8 OTUD7B OTUD7B CHP1 CHP1 INSIG1 INSIG1 NDFIP2 NDFIP2 NSFL1C NSFL1C UCP2 UCP2 MDFIC MDFIC RSAD2 RSAD2 BAG3 BAG3 DRD2 DRD2 SIRT4 SIRT4 FKBP1B FKBP1B SYTL4 SYTL4 ABHD17C ABHD17C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C11orf65Chromosome 11 open reading frame 65. (312 aa)
LYPD1LY6/PLAUR domain containing 1. (141 aa)
ASTN2Astrotactin 2. (1224 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (446 aa)
COMMD1Copper metabolism domain containing 1. (188 aa)
CLTCL1Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1632 aa)
BARD1BRCA1 associated RING domain 1. (751 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
RESTRE1 silencing transcription factor. (930 aa)
NR1H3Liver X receptor alpha. (447 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
FAM3DFamily with sequence similarity 3 member D. (223 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (435 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (372 aa)
RAB11FIP3RAB11 family interacting protein 3. (455 aa)
BCL2L1Bcl-X. (233 aa)
DCLK3Doublecortin like kinase 3. (631 aa)
ITGB1BP1PID domain-containing protein. (200 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
PSMD9PDZ domain-containing protein. (283 aa)
RAB11FIP1FIP-RBD domain-containing protein. (910 aa)
NDUFAF2NADH:ubiquinone oxidoreductase complex assembly factor 2. (169 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
AP2M1AP-2 complex subunit mu; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but i [...] (435 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
RAB23RAB23, member RAS oncogene family. (248 aa)
INHBBInhibin subunit beta B. (302 aa)
UBE2J1Ubiquitin conjugating enzyme E2 J1. (318 aa)
JAGN1Jagunal homolog 1. (183 aa)
MAP1AUncharacterized protein. (2793 aa)
GDI2Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (445 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (308 aa)
ERP29Endoplasmic reticulum resident protein 29; Does not seem to be a disulfide isomerase. (261 aa)
CTNNA1Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] (993 aa)
LRRK2Leucine rich repeat kinase 2. (2499 aa)
TMEM59Transmembrane protein 59. (389 aa)
MTNR1BMelatonin receptor 1B; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CABP1Uncharacterized protein. (227 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (667 aa)
NF1Neurofibromin 1. (2841 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
FBXO4F-box protein 4. (387 aa)
TMEM98Transmembrane protein 98. (226 aa)
TP53INP2Uncharacterized protein. (124 aa)
SYT4Synaptotagmin 4. (425 aa)
KLF7Kruppel like factor 7. (302 aa)
ILRUNPNT domain-containing protein. (468 aa)
PKIGUncharacterized protein. (131 aa)
LZTFL1Leucine zipper transcription factor like 1. (299 aa)
VPS35Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting. (796 aa)
CCN3Cellular communication network factor 3. (357 aa)
NUMBNUMB endocytic adaptor protein. (604 aa)
WWP2E3 ubiquitin-protein ligase. (868 aa)
TTBK2Tau tubulin kinase 2. (1242 aa)
SERGEFSecretion regulating guanine nucleotide exchange factor. (439 aa)
LATS1Large tumor suppressor kinase 1. (1124 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1339 aa)
LATS2Large tumor suppressor kinase 2. (1142 aa)
PID1PID domain-containing protein. (509 aa)
ACTN2Actinin alpha 2. (893 aa)
ANGPT1Angiopoietin 1. (551 aa)
ANKRD13AAnkyrin repeat domain 13A. (659 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
PPP3CASerine/threonine-protein phosphatase. (695 aa)
DAB2DAB adaptor protein 2. (769 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
ENSOCUP00000043938Uncharacterized protein. (50 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1682 aa)
ENSOCUP00000042868RBR-type E3 ubiquitin transferase. (139 aa)
SNX3PX domain-containing protein. (131 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
SVIPUncharacterized protein. (231 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (453 aa)
PARK7Parkinsonism associated deglycase. (231 aa)
ENSOCUP00000039179DPH-type MB domain-containing protein. (113 aa)
HADHHydroxyacyl-CoA dehydrogenase. (424 aa)
RHBDF2Rhomboid 5 homolog 2. (849 aa)
RAB11FIP5Uncharacterized protein. (1311 aa)
FRMD4AFERM domain containing 4A. (1064 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (495 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
POLR1ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1713 aa)
RHOQUncharacterized protein. (356 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
SIN3ASIN3 transcription regulator family member A. (1241 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
UBE2G2Ubiquitin conjugating enzyme E2 G2; Belongs to the ubiquitin-conjugating enzyme family. (198 aa)
ADTRPAndrogen dependent TFPI regulating protein. (256 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1110 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (419 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (532 aa)
ENSOCUP00000031187TRF domain-containing protein. (274 aa)
DCLK1Doublecortin like kinase 1. (740 aa)
ENSOCUP00000030650Rad60-SLD domain-containing protein. (173 aa)
UBXN2BUBX domain protein 2B. (391 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
GHRLUncharacterized protein. (234 aa)
GOPCPDZ domain-containing protein. (462 aa)
ABHD17BAbhydrolase domain containing 17B. (332 aa)
MACROH2A1H2A histone family member Y; Belongs to the histone H2A family. (418 aa)
NDFIP1Nedd4 family interacting protein 1. (226 aa)
U3KN82_RABITRab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (254 aa)
SIAH3E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (266 aa)
TRIM29Tripartite motif containing 29. (599 aa)
RHBDF1Rhomboid 5 homolog 1. (914 aa)
MAGED1MAGE family member D1. (823 aa)
G1U8W6_RABITRab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (428 aa)
ERLEC1Endoplasmic reticulum lectin 1. (508 aa)
DRD3Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (399 aa)
G1U7N5_RABITPID domain-containing protein. (200 aa)
SAPCD2Suppressor APC domain containing 2. (344 aa)
G1U4L1_RABITUncharacterized protein. (195 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
DERL3Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (234 aa)
SNX33Sorting nexin 33. (536 aa)
OS9OS9 endoplasmic reticulum lectin. (507 aa)
LEPROTLeptin receptor overlapping transcript. (147 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1052 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
MTNR1AMelatonin receptor 1A; Belongs to the G-protein coupled receptor 1 family. (312 aa)
VSNL1Visinin like 1. (191 aa)
MRAP2Melanocortin 2 receptor accessory protein 2. (209 aa)
G1TZT2_RABITMHD domain-containing protein; Belongs to the adaptor complexes medium subunit family. (416 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1131 aa)
PARK2E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (394 aa)
DMTNDematin actin binding protein. (424 aa)
MRAPMelanocortin 2 receptor accessory protein. (149 aa)
ADIPOQC1q domain-containing protein. (244 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (164 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (460 aa)
G1TSW1_RABITUbiquitin-like domain-containing protein. (62 aa)
CHGAUncharacterized protein. (289 aa)
RANGAP1Ran GTPase activating protein 1. (630 aa)
PKIAcAMP-dependent protein kinase inhibitor alpha; Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains; Belongs to the PKI family. (76 aa)
FERMT1Fermitin family member 1. (694 aa)
BTF3Transcription factor BTF3; Belongs to the NAC-beta family. (162 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms [...] (858 aa)
APODApolipoprotein D; APOD occurs in the macromolecular complex with lecithin- transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts; Belongs to the calycin superfamily. Lipocalin family. (233 aa)
G1TG12_RABITSmall ubiquitin-related modifier. (87 aa)
CDT1Chromatin licensing and DNA replication factor 1. (365 aa)
FLCNFolliculin. (579 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (426 aa)
HMGCR3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. (826 aa)
ABI3ABI family member 3. (366 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (324 aa)
DPH3Diphthamide biosynthesis 3. (82 aa)
TRIM40Tripartite motif containing 40. (229 aa)
BAG4BCL2 associated athanogene 4. (459 aa)
SNX12Sorting nexin 12. (257 aa)
FOXO1Fork-head domain-containing protein. (613 aa)
YOD1YOD1 deubiquitinase. (348 aa)
ABCC8Uncharacterized protein. (1086 aa)
OTUD7BOTU deubiquitinase 7B. (843 aa)
CHP1Calcineurin like EF-hand protein 1. (194 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (292 aa)
NDFIP2Nedd4 family interacting protein 2. (316 aa)
NSFL1CNSFL1 cofactor. (373 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
MDFICMyoD family inhibitor domain containing protein (Predicted). (247 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (396 aa)
BAG3BCL2 associated athanogene 3. (805 aa)
DRD2Dopamine receptor D2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (331 aa)
FKBP1BPeptidyl-prolyl cis-trans isomerase FKBP1B; Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). (96 aa)
SYTL4Synaptotagmin like 4. (671 aa)
ABHD17CUncharacterized protein. (94 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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