STRINGSTRING
PDGFRA PDGFRA CRKL CRKL EDNRA EDNRA MTHFD1L MTHFD1L SETD2 SETD2 IRX5 IRX5 IRF6 IRF6 WDR19 WDR19 GRHL2 GRHL2 RAB23 RAB23 TGFB2 TGFB2 NIPBL NIPBL GLI3 GLI3 RDH10 RDH10 G1SV95_RABIT G1SV95_RABIT NODAL NODAL ALX3 ALX3 FREM1 FREM1 CEP55 CEP55 BMP4 BMP4 MMP16 MMP16 SMAD2 SMAD2 TGFB3 TGFB3 PRRX1 PRRX1 TP63 TP63 MED12 MED12 ENSOCUP00000045925 ENSOCUP00000045925 WNT9B WNT9B TMEM107 TMEM107 ENSOCUP00000044284 ENSOCUP00000044284 CPLANE2 CPLANE2 ENSOCUP00000042043 ENSOCUP00000042043 ENSOCUP00000041840 ENSOCUP00000041840 TULP3 TULP3 TFAP2A TFAP2A ENSOCUP00000037329 ENSOCUP00000037329 TGFBR1 TGFBR1 FOXN3 FOXN3 FGFR2 FGFR2 CTNNB1 CTNNB1 LOC103345451 LOC103345451 NDST1 NDST1 TGFBR2 TGFBR2 SMAD3 SMAD3 G1U373_RABIT G1U373_RABIT COLEC10 COLEC10 RIC1 RIC1 SIX2 SIX2 HOXA1 HOXA1 SLC39A1 SLC39A1 IFT140 IFT140 TIFAB TIFAB FGF4 FGF4 ZIC3 ZIC3 MEGF8 MEGF8 LOC100346323 LOC100346323 HOXA2 HOXA2 EXT1 EXT1 TBX1 TBX1 SIX1 SIX1 INSIG1 INSIG1 TBX15 TBX15 PAX5 PAX5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRAProtein kinase domain-containing protein. (773 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (979 aa)
SETD2Uncharacterized protein. (625 aa)
IRX5Iroquois homeobox 5. (439 aa)
IRF6Interferon regulatory factor 6. (564 aa)
WDR19WD repeat domain 19. (1342 aa)
GRHL2Grainyhead like transcription factor 2. (728 aa)
RAB23RAB23, member RAS oncogene family. (248 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NIPBLNipped-B protein. (2580 aa)
GLI3GLI family zinc finger 3. (1575 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
NODALNodal growth differentiation factor. (348 aa)
ALX3ALX homeobox 3. (343 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
CEP55Centrosomal protein 55. (463 aa)
BMP4Bone morphogenetic protein 4; Induces cartilage and bone formation. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). (409 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
PRRX1Paired related homeobox 1. (278 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
MED12Mediator complex subunit 12. (2142 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (431 aa)
TMEM107Transmembrane protein 107. (140 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (325 aa)
ENSOCUP00000042043Ig-like domain-containing protein. (212 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (614 aa)
TFAP2ATranscription factor AP-2 alpha. (732 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (486 aa)
FOXN3Forkhead box N3. (498 aa)
FGFR2Fibroblast growth factor receptor. (894 aa)
CTNNB1Catenin beta 1. (741 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (929 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
SMAD3SMAD family member 3. (230 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
COLEC10Collectin subfamily member 10. (277 aa)
RIC1RIC1 homolog, RAB6A GEF complex partner 1. (1423 aa)
SIX2SIX homeobox 2. (295 aa)
HOXA1Homeobox A1 isoform a (Predicted). (337 aa)
SLC39A1Solute carrier family 39 member 1. (327 aa)
IFT140Intraflagellar transport 140. (1460 aa)
TIFABUncharacterized protein. (288 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
ZIC3Zic family member 3. (467 aa)
MEGF8Uncharacterized protein. (439 aa)
LOC100346323Uncharacterized protein. (240 aa)
HOXA2Homeobox domain-containing protein. (374 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
TBX1Uncharacterized protein. (440 aa)
SIX1SIX homeobox 1. (284 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (292 aa)
TBX15T-box transcription factor 15. (602 aa)
PAX5Paired box 5. (371 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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