node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSOCUP00000037329 | ENSOCUP00000044284 | ENSOCUP00000037329 | ENSOCUP00000044284 | TGFb_propeptide domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.412 |
ENSOCUP00000037329 | IL4 | ENSOCUP00000037329 | ENSOCUP00000025135 | TGFb_propeptide domain-containing protein. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.704 |
ENSOCUP00000037329 | IL6 | ENSOCUP00000037329 | ENSOCUP00000017266 | TGFb_propeptide domain-containing protein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.818 |
ENSOCUP00000037329 | JAK2 | ENSOCUP00000037329 | ENSOCUP00000014491 | TGFb_propeptide domain-containing protein. | Tyrosine-protein kinase. | 0.410 |
ENSOCUP00000037329 | LEP | ENSOCUP00000037329 | ENSOCUP00000008782 | TGFb_propeptide domain-containing protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.408 |
ENSOCUP00000037329 | LOC103345451 | ENSOCUP00000037329 | ENSOCUP00000031740 | TGFb_propeptide domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.419 |
ENSOCUP00000044284 | ENSOCUP00000037329 | ENSOCUP00000044284 | ENSOCUP00000037329 | TGFb_propeptide domain-containing protein. | TGFb_propeptide domain-containing protein. | 0.412 |
ENSOCUP00000044284 | IL4 | ENSOCUP00000044284 | ENSOCUP00000025135 | TGFb_propeptide domain-containing protein. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.704 |
ENSOCUP00000044284 | IL6 | ENSOCUP00000044284 | ENSOCUP00000017266 | TGFb_propeptide domain-containing protein. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.818 |
ENSOCUP00000044284 | JAK2 | ENSOCUP00000044284 | ENSOCUP00000014491 | TGFb_propeptide domain-containing protein. | Tyrosine-protein kinase. | 0.410 |
ENSOCUP00000044284 | LEP | ENSOCUP00000044284 | ENSOCUP00000008782 | TGFb_propeptide domain-containing protein. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.408 |
ERBB4 | JAK2 | ENSOCUP00000035750 | ENSOCUP00000014491 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.495 |
ERBB4 | PTK2B | ENSOCUP00000035750 | ENSOCUP00000018603 | Receptor protein-tyrosine kinase. | Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. | 0.497 |
G1SV95_RABIT | IL6 | ENSOCUP00000007334 | ENSOCUP00000017266 | Transforming growth factor beta; Belongs to the TGF-beta family. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.407 |
G1U0P1_RABIT | JAK2 | ENSOCUP00000022922 | ENSOCUP00000014491 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.488 |
G1U0P1_RABIT | TYK2 | ENSOCUP00000022922 | ENSOCUP00000036146 | Uncharacterized protein. | Non-specific protein-tyrosine kinase. | 0.571 |
IL10RA | IL23A | ENSOCUP00000027490 | ENSOCUP00000006251 | Interleukin 10 receptor subunit alpha. | Interleukin 23 subunit alpha. | 0.664 |
IL10RA | IL26 | ENSOCUP00000027490 | ENSOCUP00000000432 | Interleukin 10 receptor subunit alpha. | Interleukin 26. | 0.441 |
IL10RA | IL4 | ENSOCUP00000027490 | ENSOCUP00000025135 | Interleukin 10 receptor subunit alpha. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.825 |
IL10RA | IL6 | ENSOCUP00000027490 | ENSOCUP00000017266 | Interleukin 10 receptor subunit alpha. | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] | 0.898 |