STRINGSTRING
IL26 IL26 PRL PRL PIBF1 PIBF1 IL23A IL23A G1SV95_RABIT G1SV95_RABIT LEP LEP MGAT5 MGAT5 IL7R IL7R CYP1B1 CYP1B1 JAK2 JAK2 IL6 IL6 ENSOCUP00000045925 ENSOCUP00000045925 PTK2B PTK2B F2R F2R HES1 HES1 TSLP TSLP G1U0P1_RABIT G1U0P1_RABIT AGAP2 AGAP2 IL4 IL4 IL23R IL23R IL10RA IL10RA CRLF3 CRLF3 LOC103345451 LOC103345451 KIT KIT ERBB4 ERBB4 TYK2 TYK2 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000044284 ENSOCUP00000044284
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL26Interleukin 26. (180 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (262 aa)
PIBF1Progesterone immunomodulatory binding factor 1. (757 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
MGAT5Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase. (741 aa)
IL7RInterleukin 7 receptor. (458 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (542 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (460 aa)
HES1Hes family bHLH transcription factor 1. (279 aa)
TSLPUncharacterized protein. (149 aa)
G1U0P1_RABITUncharacterized protein. (209 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (836 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
IL23RInterleukin 23 receptor. (622 aa)
IL10RAInterleukin 10 receptor subunit alpha. (540 aa)
CRLF3Cytokine receptor like factor 3. (440 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (970 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
TYK2Non-specific protein-tyrosine kinase. (1065 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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