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N4BP2L1 N4BP2L1 CCNE1 CCNE1 FGF2 FGF2 KDM1A KDM1A KDR KDR NR2E1 NR2E1 THPO THPO PDCD2 PDCD2 G1SV95_RABIT G1SV95_RABIT FGF10 FGF10 WNT10B WNT10B PTPRC PTPRC PRRX1 PRRX1 TBX3 TBX3 G1TBJ9_RABIT G1TBJ9_RABIT VEGFC VEGFC HOXA3 HOXA3 SOX11 SOX11 FGF4 FGF4 OSR2 OSR2 GJA1 GJA1 G1U373_RABIT G1U373_RABIT ATXN1L ATXN1L WNT1 WNT1 SHOX2 SHOX2 FERMT2 FERMT2 CITED1 CITED1 KAT7 KAT7 LOC103345451 LOC103345451 ENSOCUP00000032400 ENSOCUP00000032400 KITLG KITLG ENSOCUP00000036570 ENSOCUP00000036570 ENSOCUP00000037329 ENSOCUP00000037329 ENSOCUP00000037873 ENSOCUP00000037873 WNT5A WNT5A TIAL1 TIAL1 ENSOCUP00000041840 ENSOCUP00000041840 ENSOCUP00000044284 ENSOCUP00000044284 HNRNPU HNRNPU ENSOCUP00000045925 ENSOCUP00000045925 TP63 TP63
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
N4BP2L1Uncharacterized protein. (1168 aa)
CCNE1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (436 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (848 aa)
KDRUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
NR2E1Uncharacterized protein. (475 aa)
THPOThrombopoietin. (348 aa)
PDCD2Programmed cell death 2. (344 aa)
G1SV95_RABITTransforming growth factor beta; Belongs to the TGF-beta family. (387 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1310 aa)
PRRX1Paired related homeobox 1. (278 aa)
TBX3Uncharacterized protein. (242 aa)
G1TBJ9_RABITUncharacterized protein. (276 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (418 aa)
HOXA3Homeobox domain-containing protein. (440 aa)
SOX11Transcription factor SOX. (446 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
GJA1Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (356 aa)
G1U373_RABITSRCR domain-containing protein; Belongs to the heparin-binding growth factors family. (200 aa)
ATXN1LAtaxin 1 like. (667 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
SHOX2Short stature homeobox 2. (211 aa)
FERMT2Fermitin family member 2. (696 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (360 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (614 aa)
LOC103345451TGFb_propeptide domain-containing protein. (203 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
ENSOCUP00000036570CYCLIN domain-containing protein; Belongs to the cyclin family. (339 aa)
ENSOCUP00000037329TGFb_propeptide domain-containing protein. (263 aa)
ENSOCUP00000037873Uncharacterized protein. (411 aa)
WNT5AProtein Wnt-5a; Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta- catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur. Inhibits tumor formation. Stimulates cell migration. Decrease [...] (380 aa)
TIAL1TIA1 cytotoxic granule associated RNA binding protein like 1. (382 aa)
ENSOCUP00000041840TGFb_propeptide domain-containing protein. (219 aa)
ENSOCUP00000044284TGFb_propeptide domain-containing protein. (260 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (844 aa)
ENSOCUP00000045925TGFb_propeptide domain-containing protein. (272 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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