(57 nodes) Regulation of stem cell differentiation network (Oryctolagus cuniculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	NKX2-5	NK2 homeobox 5. (326 aa)
	PDGFRA	Protein kinase domain-containing protein. (773 aa)
	METTL3	Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Belongs to the heparin-binding growth factors family. (155 aa)
	CDK12	Cyclin dependent kinase 12. (1492 aa)
	REST	RE1 silencing transcription factor. (930 aa)
	GATA4	GATA binding protein 4. (444 aa)
	SMYD5	SMYD family member 5. (421 aa)
	PWP1	PWP1 homolog, endonuclein. (499 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	ZFP36	ZFP36 ring finger protein. (338 aa)
	SP7	Sp7 transcription factor. (431 aa)
	SLC4A11	Solute carrier family 4 member 11. (882 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	MTCH2	Mitochondrial carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (303 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
	KDM4C	Lysine demethylase 4C. (1050 aa)
	EIF2AK2	Interferon-induced double-stranded RNA-activated protein kinase. (547 aa)
	TEAD2	TEA domain transcription factor 2. (405 aa)
	MTA2	Metastasis associated 1 family member 2. (668 aa)
	KDM3A	Lysine demethylase 3A. (1324 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	SOX17	HMG box domain-containing protein. (165 aa)
	TBX5	T-box transcription factor 5. (518 aa)
	TACSTD2	Tumor associated calcium signal transducer 2. (327 aa)
	TBX3	Uncharacterized protein. (242 aa)
	BBS12	Bardet-Biedl syndrome 12. (708 aa)
	CDK13	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (418 aa)
	NUDT21	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
	TCF15	Transcription factor 15. (199 aa)
	CHD3	Chromodomain helicase DNA binding protein 3. (1901 aa)
	G1TQQ3_RABIT	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (220 aa)
	G1TSJ3_RABIT	Uncharacterized protein. (176 aa)
	CHD4	Uncharacterized protein. (1940 aa)
	HES1	Hes family bHLH transcription factor 1. (279 aa)
	NFE2L2	Nuclear factor, erythroid 2 like 2. (677 aa)
	PTN	Pleiotrophin. (242 aa)
	RBM24	RNA binding motif protein 24. (192 aa)
	OCIAD1	OCIA domain containing 1. (285 aa)
	SOX6	SRY-box transcription factor 6. (855 aa)
	ENSOCUP00000032400	Uncharacterized protein. (531 aa)
	NSUN2	NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (1007 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (433 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (620 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (349 aa)
	HDAC2	Histone deacetylase 2. (581 aa)
	SOX5	SRY-box transcription factor 5. (779 aa)
	ESRRB	Estrogen related receptor beta. (454 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (769 aa)
	ENSOCUP00000042043	Ig-like domain-containing protein. (212 aa)
	PUS7	Pseudouridine synthase 7. (720 aa)
	DHX36	DEAH-box helicase 36. (1468 aa)
	GATAD2B	GATA zinc finger domain containing 2B. (620 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (844 aa)
	GATAD2A	GATA zinc finger domain containing 2A. (662 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (814 aa)
	N4BP2L1	Uncharacterized protein. (1168 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK6	EZH2	ENSOCUP00000039381	ENSOCUP00000041806	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.657
CDK6	STAT3	ENSOCUP00000039381	ENSOCUP00000009494	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Signal transducer and activator of transcription.	0.707
CHD3	CHD4	ENSOCUP00000018080	ENSOCUP00000020108	Chromodomain helicase DNA binding protein 3.	Uncharacterized protein.	0.986
CHD3	EZH2	ENSOCUP00000018080	ENSOCUP00000041806	Chromodomain helicase DNA binding protein 3.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.523
CHD3	GATAD2A	ENSOCUP00000018080	ENSOCUP00000046188	Chromodomain helicase DNA binding protein 3.	GATA zinc finger domain containing 2A.	0.993
CHD3	GATAD2B	ENSOCUP00000018080	ENSOCUP00000044543	Chromodomain helicase DNA binding protein 3.	GATA zinc finger domain containing 2B.	0.974
CHD3	HDAC2	ENSOCUP00000018080	ENSOCUP00000040151	Chromodomain helicase DNA binding protein 3.	Histone deacetylase 2.	0.994
CHD3	KAT5	ENSOCUP00000018080	ENSOCUP00000038189	Chromodomain helicase DNA binding protein 3.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.504
CHD3	MTA2	ENSOCUP00000018080	ENSOCUP00000007644	Chromodomain helicase DNA binding protein 3.	Metastasis associated 1 family member 2.	0.959
CHD3	REST	ENSOCUP00000018080	ENSOCUP00000001526	Chromodomain helicase DNA binding protein 3.	RE1 silencing transcription factor.	0.488
CHD4	CHD3	ENSOCUP00000020108	ENSOCUP00000018080	Uncharacterized protein.	Chromodomain helicase DNA binding protein 3.	0.986
CHD4	EZH2	ENSOCUP00000020108	ENSOCUP00000041806	Uncharacterized protein.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.873
CHD4	GATAD2A	ENSOCUP00000020108	ENSOCUP00000046188	Uncharacterized protein.	GATA zinc finger domain containing 2A.	0.989
CHD4	GATAD2B	ENSOCUP00000020108	ENSOCUP00000044543	Uncharacterized protein.	GATA zinc finger domain containing 2B.	0.990
CHD4	HDAC2	ENSOCUP00000020108	ENSOCUP00000040151	Uncharacterized protein.	Histone deacetylase 2.	0.998
CHD4	KAT5	ENSOCUP00000020108	ENSOCUP00000038189	Uncharacterized protein.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.454
CHD4	MTA2	ENSOCUP00000020108	ENSOCUP00000007644	Uncharacterized protein.	Metastasis associated 1 family member 2.	0.992
CHD4	REST	ENSOCUP00000020108	ENSOCUP00000001526	Uncharacterized protein.	RE1 silencing transcription factor.	0.537
EIF2AK2	NFE2L2	ENSOCUP00000006245	ENSOCUP00000026975	Interferon-induced double-stranded RNA-activated protein kinase.	Nuclear factor, erythroid 2 like 2.	0.920
EIF2AK2	STAT3	ENSOCUP00000006245	ENSOCUP00000009494	Interferon-induced double-stranded RNA-activated protein kinase.	Signal transducer and activator of transcription.	0.703