STRINGSTRING
INHBA INHBA WWOX WWOX GDNF GDNF CSF2 CSF2 TNF TNF UNC5B UNC5B CX3CL1 CX3CL1 CTNNA1 CTNNA1 SRPX SRPX FGF10 FGF10 NF1 NF1 EYA1 EYA1 SGK3 SGK3 RIPK1 RIPK1 MCL1 MCL1 SNAI2 SNAI2 COL2A1 COL2A1 MAPK7 MAPK7 HTRA2 HTRA2 PPP2R1A PPP2R1A ZC3HC1 ZC3HC1 STRADB STRADB EYA4 EYA4 GFRAL GFRAL IL1B IL1B AGAP2 AGAP2 GATA1 GATA1 BCL2 BCL2 MAP2K5 MAP2K5 IL7 IL7 PPP2R1B PPP2R1B FGFR1 FGFR1 EYA2 EYA2 EYA3 EYA3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
INHBAInhibin subunit beta A. (424 aa)
WWOXWW domain containing oxidoreductase. (414 aa)
GDNFGlial cell derived neurotrophic factor. (159 aa)
CSF2Uncharacterized protein. (144 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (234 aa)
UNC5BUnc-5 netrin receptor B. (946 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (404 aa)
CTNNA1Catenin alpha-1; Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and [...] (993 aa)
SRPXSushi repeat containing protein X-linked. (412 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
NF1Neurofibromin 1. (2841 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (622 aa)
SGK3Non-specific serine/threonine protein kinase. (508 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (670 aa)
MCL1MCL1 apoptosis regulator, BCL2 family member. (352 aa)
SNAI2Uncharacterized protein. (268 aa)
COL2A1Fibrillar collagen NC1 domain-containing protein. (1487 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (818 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
PPP2R1AProtein phosphatase 2 scaffold subunit Aalpha. (542 aa)
ZC3HC1Zinc finger C3HC-type containing 1. (501 aa)
STRADBSTE20 related adaptor beta. (418 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
GFRALGDNF family receptor alpha like. (555 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells; Belongs to the IL-1 family. (234 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (836 aa)
GATA1GATA binding protein 1. (413 aa)
BCL2BH4_2 domain-containing protein. (389 aa)
MAP2K5Mitogen-activated protein kinase kinase 5. (551 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (175 aa)
PPP2R1BProtein phosphatase 2 scaffold subunit Abeta. (714 aa)
FGFR1Fibroblast growth factor receptor. (823 aa)
EYA2Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (596 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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