(136 nodes) External encapsulating structure network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	COL5A3	Collagen type V alpha 3 chain. (1848 aa)
	ADAMTS9	ADAM metallopeptidase with thrombospondin type 1 motif 9. (2187 aa)
	COL4A3	Collagen type IV alpha 3 chain. (1494 aa)
	COL6A2	Uncharacterized protein. (425 aa)
	TECTA	Tectorin alpha. (2153 aa)
	ADAMTS6	ADAM metallopeptidase with thrombospondin type 1 motif 6. (1116 aa)
	HPSE2	Heparanase 2 (inactive). (592 aa)
	SFSWAP	Splicing factor SWAP. (968 aa)
	MMP26	Matrix metallopeptidase 26. (265 aa)
	OLFML2B	Olfactomedin like 2B. (745 aa)
	THBS1	Thrombospondin 1. (1171 aa)
	FBN1	Fibrillin 1. (2831 aa)
	UCMA	Upper zone of growth plate and cartilage matrix associated. (138 aa)
	OTOA	Otoancorin. (1138 aa)
	SERPINE2	Serpin family E member 2; Belongs to the serpin family. (409 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	ABI3BP	ABI family member 3 binding protein. (1763 aa)
	LUM	Lumican. (338 aa)
	G1SPR7_RABIT	Uncharacterized protein. (297 aa)
	OPTC	Opticin. (303 aa)
	DCN	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
	CILP	Cartilage intermediate layer protein. (1183 aa)
	SOD3	Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen; Belongs to the Cu-Zn superoxide dismutase family. (393 aa)
	RWDD2B	RWD domain-containing protein. (319 aa)
	TECTB	Tectorin beta. (329 aa)
	RARRES2	Retinoic acid receptor responder 2. (224 aa)
	MATN1	Matrilin 1. (724 aa)
	FBN2	Fibrillin 2. (2912 aa)
	TIMP3	Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). (211 aa)
	BAG1	Uncharacterized protein. (354 aa)
	GFOD2	Glucose-fructose oxidoreductase domain containing 2. (385 aa)
	FMOD	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (453 aa)
	THBS4	Thrombospondin 4. (997 aa)
	LTBP1	Latent transforming growth factor beta binding protein 1. (1705 aa)
	CXorf58	Chromosome X open reading frame 58. (341 aa)
	LAMA4	Laminin subunit alpha 4. (1732 aa)
	PRELP	Proline and arginine rich end leucine rich repeat protein. (380 aa)
	FN1	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2427 aa)
	FREM1	FRAS1 related extracellular matrix 1. (2182 aa)
	PAPLN	Papilin, proteoglycan like sulfated glycoprotein. (1205 aa)
	RWDD2A	RWD domain-containing protein. (292 aa)
	P3H2	Prolyl 3-hydroxylase 2. (709 aa)
	COL8A2	Collagen type VIII alpha 2 chain. (705 aa)
	FBLN1	Fibulin 1. (457 aa)
	G1T142_RABIT	Uncharacterized protein. (378 aa)
	TGFB3	Transforming growth factor beta 3. (458 aa)
	FBN3	Fibrillin 3. (2647 aa)
	COCH	Cochlin. (551 aa)
	HSPA12B	Heat shock protein family A (Hsp70) member 12B. (794 aa)
	ZP2	Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. (743 aa)
	COL4A1	Collagen type IV alpha 1 chain. (1637 aa)
	EPYC	Epiphycan. (321 aa)
	KERA	Keratocan. (352 aa)
	HMCN1	Hemicentin 1. (5334 aa)
	CRYGN	Crystallin gamma N; Belongs to the beta/gamma-crystallin family. (178 aa)
	RBP3	Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1240 aa)
	GFOD1	Glucose-fructose oxidoreductase domain containing 1. (390 aa)
	LTBP2	Latent transforming growth factor beta binding protein 2. (1809 aa)
	EFEMP1	EGF containing fibulin extracellular matrix protein 1. (494 aa)
	USH2A	Uncharacterized protein. (1543 aa)
	MFAP4	Microfibril associated protein 4. (258 aa)
	COL12A1	Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (3112 aa)
	ZPLD1	Zona pellucida like domain containing 1. (424 aa)
	ZP3	Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (419 aa)
	TINAG	SMB domain-containing protein; Belongs to the peptidase C1 family. (474 aa)
	MYOC	Myocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (490 aa)
	SERPINE1	Serpin family E member 1; Belongs to the serpin family. (362 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
	COL15A1	Collagen type XV alpha 1 chain. (1352 aa)
	CLEC7A	C-type lectin domain containing 7A. (247 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
	MATN2	Matrilin 2. (1197 aa)
	DSPP	Uncharacterized protein. (657 aa)
	CRISP2	Cysteine rich secretory protein 2; Belongs to the CRISP family. (249 aa)
	G1TH10_RABIT	EMI domain-containing protein. (523 aa)
	SPOCK2	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
	ADAMTS10	ADAM metallopeptidase with thrombospondin type 1 motif 10. (1103 aa)
	COL26A1	Collagen type XXVI alpha 1 chain. (420 aa)
	PCSK6	Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (908 aa)
	ADNP2	ADNP homeobox 2. (1132 aa)
	LOC100349668	Uncharacterized protein. (512 aa)
	PGF	Placental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	G1TTW6_RABIT	Uncharacterized protein. (235 aa)
	PKHD1L1	PKHD1 like 1. (4226 aa)
	SDC1	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (401 aa)
	MMP11	Matrix metallopeptidase 11. (492 aa)
	G1TWE1_RABIT	Uncharacterized protein. (257 aa)
	ZP4	Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor; Belongs to the ZP domain family. ZPB subfamily. (540 aa)
	PXDN	Peroxidasin. (1411 aa)
	NCAN	Neurocan. (1177 aa)
	DEFB123	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
	COL8A1	Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). (744 aa)
	CLC	Galectin. (142 aa)
	FAM126B	Family with sequence similarity 126 member B. (586 aa)
	ASPN	Asporin. (373 aa)
	CBY3	Uncharacterized protein. (147 aa)
	ACAN	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2167 aa)
	G1U6X1_RABIT	Uncharacterized protein. (204 aa)
	ALG11	ALG11 alpha-1,2-mannosyltransferase. (649 aa)
	BGN	Biglycan; May be involved in collagen fiber assembly. (394 aa)
	C6orf15	Chromosome 6 open reading frame 15. (312 aa)
	FBLN5	Fibulin 5. (453 aa)
	ENSOCUP00000028737	Uncharacterized protein. (227 aa)
	F3	Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (397 aa)
	ENSOCUP00000029917	Uncharacterized protein. (169 aa)
	ENSOCUP00000030022	PLAC domain-containing protein. (120 aa)
	TGFBR3L	Transforming growth factor beta receptor 3 like. (313 aa)
	ENSOCUP00000031387	Uncharacterized protein. (326 aa)
	POSTN	Periostin. (845 aa)
	C2orf80	Chromosome 2 open reading frame 80. (217 aa)
	ENSOCUP00000032400	Uncharacterized protein. (531 aa)
	ENSOCUP00000032880	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (183 aa)
	MMRN2	Multimerin 2. (925 aa)
	GPLD1	Glycosylphosphatidylinositol specific phospholipase D1. (852 aa)
	CRISP3	Cysteine rich secretory protein 3; Belongs to the CRISP family. (254 aa)
	ENSOCUP00000035577	Uncharacterized protein. (517 aa)
	OLFML2A	Olfactomedin like 2A. (691 aa)
	ENSOCUP00000037812	Uncharacterized protein. (1162 aa)
	ENSOCUP00000038426	Uncharacterized protein. (831 aa)
	ENSOCUP00000038657	Uncharacterized protein. (296 aa)
	FBLN2	Fibulin 2. (1286 aa)
	ENSOCUP00000039914	PLAC domain-containing protein. (118 aa)
	SMOC1	SPARC related modular calcium binding 1. (445 aa)
	ENSOCUP00000040886	Uncharacterized protein. (420 aa)
	C4H12orf75	Uncharacterized protein. (51 aa)
	ZP1	Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida (By similarity); Belongs to the ZP domain family. ZPB subfamily. (638 aa)
	LOXL3	Lysyl oxidase like 3. (935 aa)
	LOX	Lysyl oxidase. (419 aa)
	TGM2	Transglutaminase 2. (845 aa)
	ENSOCUP00000045611	Uncharacterized protein. (121 aa)
	BICC1	BicC family RNA binding protein 1. (982 aa)
	ANOS1	Uncharacterized protein. (342 aa)
	LOC100339138	Galectin. (142 aa)
	CASK	Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (1000 aa)
	ENSOCUP00000047752	Uncharacterized protein. (135 aa)
	CCBE1	Collagen and calcium binding EGF domains 1. (405 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAN	ADAMTS9	ENSOCUP00000024918	ENSOCUP00000000097	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	ADAM metallopeptidase with thrombospondin type 1 motif 9.	0.707
ACAN	ASPN	ENSOCUP00000024918	ENSOCUP00000024373	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Asporin.	0.717
ACAN	BGN	ENSOCUP00000024918	ENSOCUP00000026470	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Biglycan; May be involved in collagen fiber assembly.	0.948
ACAN	CILP	ENSOCUP00000024918	ENSOCUP00000006310	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Cartilage intermediate layer protein.	0.549
ACAN	DCN	ENSOCUP00000024918	ENSOCUP00000006027	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.	0.951
ACAN	ENSOCUP00000040886	ENSOCUP00000024918	ENSOCUP00000040886	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Uncharacterized protein.	0.813
ACAN	EPYC	ENSOCUP00000024918	ENSOCUP00000011519	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Epiphycan.	0.547
ACAN	FBLN1	ENSOCUP00000024918	ENSOCUP00000009587	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibulin 1.	0.839
ACAN	FBLN2	ENSOCUP00000024918	ENSOCUP00000039245	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibulin 2.	0.742
ACAN	FBN1	ENSOCUP00000024918	ENSOCUP00000003367	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibrillin 1.	0.497
ACAN	FMOD	ENSOCUP00000024918	ENSOCUP00000007954	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.	0.947
ACAN	FN1	ENSOCUP00000024918	ENSOCUP00000008718	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	0.929
ACAN	KERA	ENSOCUP00000024918	ENSOCUP00000011522	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Keratocan.	0.771
ACAN	LUM	ENSOCUP00000024918	ENSOCUP00000004852	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Lumican.	0.893
ACAN	MATN1	ENSOCUP00000024918	ENSOCUP00000007050	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrilin 1.	0.545
ACAN	MATN2	ENSOCUP00000024918	ENSOCUP00000014938	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Matrilin 2.	0.403
ACAN	NCAN	ENSOCUP00000024918	ENSOCUP00000022977	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Neurocan.	0.438
ACAN	POSTN	ENSOCUP00000024918	ENSOCUP00000031481	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Periostin.	0.455
ACAN	PRELP	ENSOCUP00000024918	ENSOCUP00000008358	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Proline and arginine rich end leucine rich repeat protein.	0.764
ACAN	PXDN	ENSOCUP00000024918	ENSOCUP00000022906	Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.	Peroxidasin.	0.682