STRINGSTRING
FBLN1 FBLN1 COL8A2 COL8A2 P3H2 P3H2 MFAP1 MFAP1 FBN2 FBN2 MATN1 MATN1 RARRES2 RARRES2 COL6A3 COL6A3 PAPLN PAPLN FREM1 FREM1 FOXP3 FOXP3 HMCN1 HMCN1 NID2 NID2 ENSOCUP00000035577 ENSOCUP00000035577 CRISP3 CRISP3 GPLD1 GPLD1 MMRN2 MMRN2 COL11A1 COL11A1 COL5A3 COL5A3 ENSOCUP00000032400 ENSOCUP00000032400 COL4A3 COL4A3 ADAMTS9 ADAMTS9 POSTN POSTN COL5A1 COL5A1 CD4 CD4 VIT VIT TGFBR3L TGFBR3L ENSOCUP00000030022 ENSOCUP00000030022 ENSOCUP00000029917 ENSOCUP00000029917 F3 F3 FBLN5 FBLN5 MS4A12 MS4A12 FN1 FN1 LAMA3 LAMA3 MEGF9 MEGF9 PRELP PRELP IMPG1 IMPG1 KAZALD1 KAZALD1 ENSOCUP00000027326 ENSOCUP00000027326 C6orf15 C6orf15 BGN BGN IMPG2 IMPG2 BCAN BCAN NTNG1 NTNG1 OTOL1 OTOL1 ACAN ACAN MATN3 MATN3 ASPN ASPN FAM126B FAM126B COL8A1 COL8A1 COL4A5 COL4A5 THBS2 THBS2 NCAN NCAN COL10A1 COL10A1 OLFML2A OLFML2A ENSOCUP00000037812 ENSOCUP00000037812 ENSOCUP00000038426 ENSOCUP00000038426 CHADL CHADL ENSOCUP00000038976 ENSOCUP00000038976 LAMA4 LAMA4 LTBP1 LTBP1 LAMA2 LAMA2 LOXL1 LOXL1 FBLN2 FBLN2 IFNG IFNG ENSOCUP00000039914 ENSOCUP00000039914 TGFBI TGFBI ENSOCUP00000040310 ENSOCUP00000040310 SMOC1 SMOC1 ENSOCUP00000040886 ENSOCUP00000040886 SSC4D SSC4D NID1 NID1 ZP1 ZP1 LOXL3 LOXL3 PVALB PVALB SPARCL1 SPARCL1 LOX LOX ENSOCUP00000044491 ENSOCUP00000044491 NTN4 NTN4 TGM2 TGM2 COL4A6 COL4A6 ENSOCUP00000044803 ENSOCUP00000044803 CCDC80 CCDC80 ENSOCUP00000045611 ENSOCUP00000045611 ANOS1 ANOS1 CASK CASK ZNF853 ZNF853 CCBE1 CCBE1 ADAMTS13 ADAMTS13 COL6A2 COL6A2 SOD3 SOD3 COL4A4 COL4A4 CILP CILP DCN DCN EMILIN1 EMILIN1 OPTC OPTC MMRN1 MMRN1 G1SPR7_RABIT G1SPR7_RABIT COL16A1 COL16A1 LUM LUM ABI3BP ABI3BP TGFB2 TGFB2 LAMB2 LAMB2 SERPINE2 SERPINE2 IL17A IL17A ICE2 ICE2 UCMA UCMA LAMB3 LAMB3 FBN1 FBN1 THBS1 THBS1 OLFML2B OLFML2B MMP26 MMP26 EGFLAM EGFLAM ADAMTS5 ADAMTS5 C11orf53 C11orf53 THBS4 THBS4 FMOD FMOD MATN4 MATN4 GFOD2 GFOD2 TIMP3 TIMP3 ECM2 ECM2 VCAN VCAN EMILIN2 EMILIN2 COL6A6 COL6A6 MFAP5 MFAP5 HPSE2 HPSE2 ADAMTS6 ADAMTS6 PXDN PXDN EYS EYS AMZ1 AMZ1 COL28A1 COL28A1 LOC100352491 LOC100352491 ZP4 ZP4 DGCR6L DGCR6L TNC TNC MMP11 MMP11 RELL2 RELL2 LAMA1 LAMA1 LOC100349668 LOC100349668 HSPG2 HSPG2 PCSK6 PCSK6 COL26A1 COL26A1 ADAMTS10 ADAMTS10 ZNF316 ZNF316 SPOCK2 SPOCK2 NTN1 NTN1 G1TH10_RABIT G1TH10_RABIT CRISP2 CRISP2 DSPP DSPP FRAS1 FRAS1 TNR TNR MATN2 MATN2 SHH SHH ADAMTS1 ADAMTS1 COL15A1 COL15A1 WNT2 WNT2 SERPINE1 SERPINE1 MYOC MYOC TINAG TINAG ZP3 ZP3 ZPLD1 ZPLD1 COL12A1 COL12A1 COL14A1 COL14A1 MFAP4 MFAP4 COL5A2 COL5A2 COL3A1 COL3A1 AMZ2 AMZ2 USH2A USH2A LAMB1 LAMB1 EFEMP1 EFEMP1 LTBP2 LTBP2 GFOD1 GFOD1 COL2A1 COL2A1 RBP3 RBP3 ADAMTS4 ADAMTS4 KERA KERA EPYC EPYC COL4A2 COL4A2 COL4A1 COL4A1 PTPRZ1 PTPRZ1 LAMC1 LAMC1 ZP2 ZP2 COL1A1 COL1A1 COL1A2 COL1A2 SPARC SPARC COCH COCH FBN3 FBN3 TGFB3 TGFB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FBLN1Fibulin 1. (457 aa)
COL8A2Collagen type VIII alpha 2 chain. (705 aa)
P3H2Prolyl 3-hydroxylase 2. (709 aa)
MFAP1Microfibrillar-associated protein 1 (Predicted). (439 aa)
FBN2Fibrillin 2. (2912 aa)
MATN1Matrilin 1. (724 aa)
RARRES2Retinoic acid receptor responder 2. (224 aa)
COL6A3Uncharacterized protein. (562 aa)
PAPLNPapilin, proteoglycan like sulfated glycoprotein. (1205 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
FOXP3Forkhead box P3. (455 aa)
HMCN1Hemicentin 1. (5334 aa)
NID2Nidogen 2. (1388 aa)
ENSOCUP00000035577Uncharacterized protein. (517 aa)
CRISP3Cysteine rich secretory protein 3; Belongs to the CRISP family. (254 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (852 aa)
MMRN2Multimerin 2. (925 aa)
COL11A1Collagen type XI alpha 1 chain. (1857 aa)
COL5A3Collagen type V alpha 3 chain. (1848 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
COL4A3Collagen type IV alpha 3 chain. (1494 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (2187 aa)
POSTNPeriostin. (845 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (383 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
VITVitrin. (693 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (313 aa)
ENSOCUP00000030022PLAC domain-containing protein. (120 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (397 aa)
FBLN5Fibulin 5. (453 aa)
MS4A12Membrane spanning 4-domains A12. (264 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2427 aa)
LAMA3Laminin subunit alpha 3. (3340 aa)
MEGF9Multiple EGF like domains 9. (587 aa)
PRELPProline and arginine rich end leucine rich repeat protein. (380 aa)
IMPG1Interphotoreceptor matrix proteoglycan 1. (793 aa)
KAZALD1Kazal type serine peptidase inhibitor domain 1. (336 aa)
ENSOCUP00000027326Uncharacterized protein. (300 aa)
C6orf15Chromosome 6 open reading frame 15. (312 aa)
BGNBiglycan; May be involved in collagen fiber assembly. (394 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1215 aa)
BCANBrevican. (736 aa)
NTNG1Netrin G1. (539 aa)
OTOL1Otolin 1. (482 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2167 aa)
MATN3Matrilin 3. (451 aa)
ASPNAsporin. (373 aa)
FAM126BFamily with sequence similarity 126 member B. (586 aa)
COL8A1Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). (744 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
THBS2Thrombospondin 2. (1170 aa)
NCANNeurocan. (1177 aa)
COL10A1C1q domain-containing protein. (664 aa)
OLFML2AOlfactomedin like 2A. (691 aa)
ENSOCUP00000037812Uncharacterized protein. (1162 aa)
ENSOCUP00000038426Uncharacterized protein. (831 aa)
CHADLChondroadherin like. (807 aa)
ENSOCUP00000038976LAM_G_DOMAIN domain-containing protein. (152 aa)
LAMA4Laminin subunit alpha 4. (1732 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1705 aa)
LAMA2Laminin subunit alpha 2. (3126 aa)
LOXL1Lysyl oxidase like 1. (535 aa)
FBLN2Fibulin 2. (1286 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
ENSOCUP00000039914PLAC domain-containing protein. (118 aa)
TGFBITransforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions (By similarity). (701 aa)
ENSOCUP00000040310Uncharacterized protein. (411 aa)
SMOC1SPARC related modular calcium binding 1. (445 aa)
ENSOCUP00000040886Uncharacterized protein. (420 aa)
SSC4DScavenger receptor cysteine rich family member with 4 domains. (750 aa)
NID1Uncharacterized protein. (1000 aa)
ZP1Processed zona pellucida sperm-binding protein 1; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP1 ensures the structural integrity of the zona pellucida (By similarity); Belongs to the ZP domain family. ZPB subfamily. (638 aa)
LOXL3Lysyl oxidase like 3. (935 aa)
PVALBParvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family. (195 aa)
SPARCL1SPARC like 1. (670 aa)
LOXLysyl oxidase. (419 aa)
ENSOCUP00000044491Uncharacterized protein. (594 aa)
NTN4Netrin 4. (697 aa)
TGM2Transglutaminase 2. (845 aa)
COL4A6Collagen type IV alpha 6 chain. (1780 aa)
ENSOCUP00000044803Uncharacterized protein. (811 aa)
CCDC80Coiled-coil domain containing 80. (964 aa)
ENSOCUP00000045611Uncharacterized protein. (121 aa)
ANOS1Uncharacterized protein. (342 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (1000 aa)
ZNF853Zinc finger protein 853. (510 aa)
CCBE1Collagen and calcium binding EGF domains 1. (405 aa)
ADAMTS13ACR domain-containing protein. (428 aa)
COL6A2Uncharacterized protein. (425 aa)
SOD3Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen; Belongs to the Cu-Zn superoxide dismutase family. (393 aa)
COL4A4Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1687 aa)
CILPCartilage intermediate layer protein. (1183 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
EMILIN1Elastin microfibril interfacer 1. (982 aa)
OPTCOpticin. (303 aa)
MMRN1Multimerin 1. (1211 aa)
G1SPR7_RABITUncharacterized protein. (297 aa)
COL16A1Collagen type XVI alpha 1 chain. (1606 aa)
LUMLumican. (338 aa)
ABI3BPABI family member 3 binding protein. (1763 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
IL17AInterleukin 17A. (153 aa)
ICE2Interactor of little elongation complex ELL subunit 2. (965 aa)
UCMAUpper zone of growth plate and cartilage matrix associated. (138 aa)
LAMB3Laminin subunit beta 3. (1157 aa)
FBN1Fibrillin 1. (2831 aa)
THBS1Thrombospondin 1. (1171 aa)
OLFML2BOlfactomedin like 2B. (745 aa)
MMP26Matrix metallopeptidase 26. (265 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (728 aa)
ADAMTS5ADAM metallopeptidase with thrombospondin type 1 motif 5. (931 aa)
C11orf53Chromosome 11 open reading frame 53. (279 aa)
THBS4Thrombospondin 4. (997 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (453 aa)
MATN4Matrilin 4. (471 aa)
GFOD2Glucose-fructose oxidoreductase domain containing 2. (385 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). (211 aa)
ECM2Extracellular matrix protein 2. (691 aa)
VCANVersican. (3473 aa)
EMILIN2Elastin microfibril interfacer 2. (1133 aa)
COL6A6Collagen type VI alpha 6 chain. (2248 aa)
MFAP5Microfibril associated protein 5. (171 aa)
HPSE2Heparanase 2 (inactive). (592 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1116 aa)
PXDNPeroxidasin. (1411 aa)
EYSUncharacterized protein. (2456 aa)
AMZ1Archaelysin family metallopeptidase 1. (462 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1146 aa)
LOC100352491C1q domain-containing protein. (191 aa)
ZP4Processed zona pellucida sperm-binding protein 4; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor; Belongs to the ZP domain family. ZPB subfamily. (540 aa)
DGCR6LUncharacterized protein. (193 aa)
TNCTenascin C. (2384 aa)
MMP11Matrix metallopeptidase 11. (492 aa)
RELL2RELT like 2. (303 aa)
LAMA1Laminin subunit alpha 1. (3030 aa)
LOC100349668Uncharacterized protein. (512 aa)
HSPG2Heparan sulfate proteoglycan 2. (4207 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (908 aa)
COL26A1Collagen type XXVI alpha 1 chain. (420 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10. (1103 aa)
ZNF316Zinc finger protein 316. (1088 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
NTN1Netrin 1. (533 aa)
G1TH10_RABITEMI domain-containing protein. (523 aa)
CRISP2Cysteine rich secretory protein 2; Belongs to the CRISP family. (249 aa)
DSPPUncharacterized protein. (657 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (3911 aa)
TNRTenascin R. (1359 aa)
MATN2Matrilin 2. (1197 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (451 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (887 aa)
COL15A1Collagen type XV alpha 1 chain. (1352 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (362 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (490 aa)
TINAGSMB domain-containing protein; Belongs to the peptidase C1 family. (474 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (419 aa)
ZPLD1Zona pellucida like domain containing 1. (424 aa)
COL12A1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (3112 aa)
COL14A1Collagen type XIV alpha 1 chain. (1796 aa)
MFAP4Microfibril associated protein 4. (258 aa)
COL5A2Collagen type V alpha 2 chain. (1502 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
AMZ2Archaelysin family metallopeptidase 2. (360 aa)
USH2AUncharacterized protein. (1543 aa)
LAMB1Laminin subunit beta 1. (1736 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (494 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1809 aa)
GFOD1Glucose-fructose oxidoreductase domain containing 1. (390 aa)
COL2A1Fibrillar collagen NC1 domain-containing protein. (1487 aa)
RBP3Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1240 aa)
ADAMTS4ADAM metallopeptidase with thrombospondin type 1 motif 4. (851 aa)
KERAKeratocan. (352 aa)
EPYCEpiphycan. (321 aa)
COL4A2Collagen type IV alpha 2 chain. (1564 aa)
COL4A1Collagen type IV alpha 1 chain. (1637 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2272 aa)
LAMC1Laminin subunit gamma 1. (998 aa)
ZP2Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. (743 aa)
COL1A1Collagen alpha-1(I) chain. (1348 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (315 aa)
COCHCochlin. (551 aa)
FBN3Fibrillin 3. (2647 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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