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SSC4D SSC4D COL4A3 COL4A3 COL10A1 COL10A1 ADAMTS6 ADAMTS6 EMILIN2 EMILIN2 VCAN VCAN EGFLAM EGFLAM THBS1 THBS1 FBN1 FBN1 LAMB3 LAMB3 ICE2 ICE2 IL17A IL17A SERPINE2 SERPINE2 LAMB2 LAMB2 TGFB2 TGFB2 ABI3BP ABI3BP LUM LUM COL16A1 COL16A1 MMRN1 MMRN1 EMILIN1 EMILIN1 DCN DCN CILP CILP COL4A4 COL4A4 SOD3 SOD3 COL6A3 COL6A3 RARRES2 RARRES2 ECM2 ECM2 TIMP3 TIMP3 MATN4 MATN4 THBS4 THBS4 C11orf53 C11orf53 LAMA2 LAMA2 LAMA4 LAMA4 MEGF9 MEGF9 LAMA3 LAMA3 FN1 FN1 FOXP3 FOXP3 FREM1 FREM1 PAPLN PAPLN P3H2 P3H2 COL8A2 COL8A2 TGFB3 TGFB3 COCH COCH SPARC SPARC COL1A2 COL1A2 COL1A1 COL1A1 ZP2 ZP2 LAMC1 LAMC1 PTPRZ1 PTPRZ1 COL4A1 COL4A1 COL4A2 COL4A2 HMCN1 HMCN1 RBP3 RBP3 COL2A1 COL2A1 LAMB1 LAMB1 USH2A USH2A COL3A1 COL3A1 COL5A2 COL5A2 MFAP4 MFAP4 COL14A1 COL14A1 COL12A1 COL12A1 ZPLD1 ZPLD1 ZP3 ZP3 TINAG TINAG MYOC MYOC SERPINE1 SERPINE1 WNT2 WNT2 COL15A1 COL15A1 MATN2 MATN2 TNR TNR FRAS1 FRAS1 DSPP DSPP NTN1 NTN1 ADAMTS10 ADAMTS10 PCSK6 PCSK6 HSPG2 HSPG2 LOC100349668 LOC100349668 LAMA1 LAMA1 RELL2 RELL2 TNC TNC LOC100352491 LOC100352491 COL28A1 COL28A1 EYS EYS PXDN PXDN NCAN NCAN COL4A5 COL4A5 COL8A1 COL8A1 MATN3 MATN3 ACAN ACAN OTOL1 OTOL1 NTNG1 NTNG1 BCAN BCAN IMPG2 IMPG2 C6orf15 C6orf15 KAZALD1 KAZALD1 IMPG1 IMPG1 MS4A12 MS4A12 FBLN5 FBLN5 ENSOCUP00000029917 ENSOCUP00000029917 VIT VIT CD4 CD4 COL5A1 COL5A1 POSTN POSTN ENSOCUP00000032400 ENSOCUP00000032400 COL5A3 COL5A3 COL11A1 COL11A1 MMRN2 MMRN2 NID2 NID2 CHADL CHADL ENSOCUP00000038976 ENSOCUP00000038976 FBLN2 FBLN2 IFNG IFNG TGFBI TGFBI SMOC1 SMOC1 ENSOCUP00000040886 ENSOCUP00000040886 NID1 NID1 LOXL3 LOXL3 PVALB PVALB SPARCL1 SPARCL1 ENSOCUP00000044491 ENSOCUP00000044491 NTN4 NTN4 COL4A6 COL4A6 ENSOCUP00000044803 ENSOCUP00000044803 CCDC80 CCDC80 CASK CASK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SSC4DScavenger receptor cysteine rich family member with 4 domains. (750 aa)
COL4A3Collagen type IV alpha 3 chain. (1494 aa)
COL10A1C1q domain-containing protein. (664 aa)
ADAMTS6ADAM metallopeptidase with thrombospondin type 1 motif 6. (1116 aa)
EMILIN2Elastin microfibril interfacer 2. (1133 aa)
VCANVersican. (3473 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (728 aa)
THBS1Thrombospondin 1. (1171 aa)
FBN1Fibrillin 1. (2831 aa)
LAMB3Laminin subunit beta 3. (1157 aa)
ICE2Interactor of little elongation complex ELL subunit 2. (965 aa)
IL17AInterleukin 17A. (153 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
LAMB2Laminin subunit beta 2. (1802 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ABI3BPABI family member 3 binding protein. (1763 aa)
LUMLumican. (338 aa)
COL16A1Collagen type XVI alpha 1 chain. (1606 aa)
MMRN1Multimerin 1. (1211 aa)
EMILIN1Elastin microfibril interfacer 1. (982 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
CILPCartilage intermediate layer protein. (1183 aa)
COL4A4Collagen alpha-4(IV) chain; Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (1687 aa)
SOD3Extracellular superoxide dismutase [Cu-Zn]; Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen; Belongs to the Cu-Zn superoxide dismutase family. (393 aa)
COL6A3Uncharacterized protein. (562 aa)
RARRES2Retinoic acid receptor responder 2. (224 aa)
ECM2Extracellular matrix protein 2. (691 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). (211 aa)
MATN4Matrilin 4. (471 aa)
THBS4Thrombospondin 4. (997 aa)
C11orf53Chromosome 11 open reading frame 53. (279 aa)
LAMA2Laminin subunit alpha 2. (3126 aa)
LAMA4Laminin subunit alpha 4. (1732 aa)
MEGF9Multiple EGF like domains 9. (587 aa)
LAMA3Laminin subunit alpha 3. (3340 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2427 aa)
FOXP3Forkhead box P3. (455 aa)
FREM1FRAS1 related extracellular matrix 1. (2182 aa)
PAPLNPapilin, proteoglycan like sulfated glycoprotein. (1205 aa)
P3H2Prolyl 3-hydroxylase 2. (709 aa)
COL8A2Collagen type VIII alpha 2 chain. (705 aa)
TGFB3Transforming growth factor beta 3. (458 aa)
COCHCochlin. (551 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity); Belongs to the SPARC family. (315 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen); Belongs to the fibrillar collagen family. (1364 aa)
COL1A1Collagen alpha-1(I) chain. (1348 aa)
ZP2Processed zona pellucida sperm-binding protein 2; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor. Belongs to the ZP domain family. ZPA subfamily. (743 aa)
LAMC1Laminin subunit gamma 1. (998 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2272 aa)
COL4A1Collagen type IV alpha 1 chain. (1637 aa)
COL4A2Collagen type IV alpha 2 chain. (1564 aa)
HMCN1Hemicentin 1. (5334 aa)
RBP3Retinol-binding protein 3; IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. (1240 aa)
COL2A1Fibrillar collagen NC1 domain-containing protein. (1487 aa)
LAMB1Laminin subunit beta 1. (1736 aa)
USH2AUncharacterized protein. (1543 aa)
COL3A1Collagen type III alpha 1 chain. (1462 aa)
COL5A2Collagen type V alpha 2 chain. (1502 aa)
MFAP4Microfibril associated protein 4. (258 aa)
COL14A1Collagen type XIV alpha 1 chain. (1796 aa)
COL12A1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (3112 aa)
ZPLD1Zona pellucida like domain containing 1. (424 aa)
ZP3Processed zona pellucida sperm-binding protein 3; Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation. (419 aa)
TINAGSMB domain-containing protein; Belongs to the peptidase C1 family. (474 aa)
MYOCMyocilin, C-terminal fragment; Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. [...] (490 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (362 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). (360 aa)
COL15A1Collagen type XV alpha 1 chain. (1352 aa)
MATN2Matrilin 2. (1197 aa)
TNRTenascin R. (1359 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (3911 aa)
DSPPUncharacterized protein. (657 aa)
NTN1Netrin 1. (533 aa)
ADAMTS10ADAM metallopeptidase with thrombospondin type 1 motif 10. (1103 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (908 aa)
HSPG2Heparan sulfate proteoglycan 2. (4207 aa)
LOC100349668Uncharacterized protein. (512 aa)
LAMA1Laminin subunit alpha 1. (3030 aa)
RELL2RELT like 2. (303 aa)
TNCTenascin C. (2384 aa)
LOC100352491C1q domain-containing protein. (191 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1146 aa)
EYSUncharacterized protein. (2456 aa)
PXDNPeroxidasin. (1411 aa)
NCANNeurocan. (1177 aa)
COL4A5Collagen type IV alpha 5 chain. (1691 aa)
COL8A1Collagen alpha-1(VIII) chain; Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis (By similarity). (744 aa)
MATN3Matrilin 3. (451 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2167 aa)
OTOL1Otolin 1. (482 aa)
NTNG1Netrin G1. (539 aa)
BCANBrevican. (736 aa)
IMPG2Interphotoreceptor matrix proteoglycan 2. (1215 aa)
C6orf15Chromosome 6 open reading frame 15. (312 aa)
KAZALD1Kazal type serine peptidase inhibitor domain 1. (336 aa)
IMPG1Interphotoreceptor matrix proteoglycan 1. (793 aa)
MS4A12Membrane spanning 4-domains A12. (264 aa)
FBLN5Fibulin 5. (453 aa)
ENSOCUP00000029917Uncharacterized protein. (169 aa)
VITVitrin. (693 aa)
CD4T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...] (536 aa)
COL5A1Fibrillar collagen NC1 domain-containing protein. (383 aa)
POSTNPeriostin. (845 aa)
ENSOCUP00000032400Uncharacterized protein. (531 aa)
COL5A3Collagen type V alpha 3 chain. (1848 aa)
COL11A1Collagen type XI alpha 1 chain. (1857 aa)
MMRN2Multimerin 2. (925 aa)
NID2Nidogen 2. (1388 aa)
CHADLChondroadherin like. (807 aa)
ENSOCUP00000038976LAM_G_DOMAIN domain-containing protein. (152 aa)
FBLN2Fibulin 2. (1286 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
TGFBITransforming growth factor-beta-induced protein ig-h3; Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions (By similarity). (701 aa)
SMOC1SPARC related modular calcium binding 1. (445 aa)
ENSOCUP00000040886Uncharacterized protein. (420 aa)
NID1Uncharacterized protein. (1000 aa)
LOXL3Lysyl oxidase like 3. (935 aa)
PVALBParvalbumin alpha; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions; Belongs to the parvalbumin family. (195 aa)
SPARCL1SPARC like 1. (670 aa)
ENSOCUP00000044491Uncharacterized protein. (594 aa)
NTN4Netrin 4. (697 aa)
COL4A6Collagen type IV alpha 6 chain. (1780 aa)
ENSOCUP00000044803Uncharacterized protein. (811 aa)
CCDC80Coiled-coil domain containing 80. (964 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (1000 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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