(43 nodes) FERM domain network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (996 aa)
	FRMD6	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (632 aa)
	EPB41L1	Erythrocyte membrane protein band 4.1 like 1. (947 aa)
	EPB41L2	Erythrocyte membrane protein band 4.1 like 2. (1105 aa)
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1005 aa)
	EPB41L3	Erythrocyte membrane protein band 4.1 like 3. (1447 aa)
	EPB41L4A	Erythrocyte membrane protein band 4.1 like 4A. (691 aa)
	EZR	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (653 aa)
	PTPN21	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1178 aa)
	PTPN13	Tyrosine-protein phosphatase non-receptor type 13; Regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. (2478 aa)
	FRMD4A	FERM domain containing 4A. (1064 aa)
	RDX	Radixin. (643 aa)
	TYK2	Non-specific protein-tyrosine kinase. (1065 aa)
	ENSOCUP00000034544	FERM domain-containing protein. (508 aa)
	FRMD3	FERM domain containing 3. (583 aa)
	FRMPD1	FERM and PDZ domain containing 1. (1589 aa)
	FRMD8	FERM domain containing 8. (591 aa)
	PTK2	Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1041 aa)
	FARP1	FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1129 aa)
	PLEKHH2	Pleckstrin homology, MyTH4 and FERM domain containing H2. (1533 aa)
	MYO10	Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2067 aa)
	FRMPD4	FERM and PDZ domain containing 4. (1255 aa)
	FRMD7	FERM domain containing 7. (710 aa)
	MYO7B	Myosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2119 aa)
	MYO7A	Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2148 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	EPB41L4B	Erythrocyte membrane protein band 4.1 like 4B. (811 aa)
	PTPN14	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1180 aa)
	TLN2	Talin 2. (2536 aa)
	FRMPD2	FERM and PDZ domain containing 2. (1306 aa)
	TLN1	Talin 1. (2558 aa)
	FARP2	FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1013 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (731 aa)
	PTPN4	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
	MYLIP	Myosin regulatory light chain interacting protein. (425 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (860 aa)
	JAK1	Tyrosine-protein kinase. (1151 aa)
	NF2	Neurofibromin 2. (626 aa)
	KRIT1	Uncharacterized protein. (736 aa)
	FRMD4B	FERM domain containing 4B. (1063 aa)
	FRMD5	FERM domain containing 5. (570 aa)
	PLEKHH1	Pleckstrin homology, MyTH4 and FERM domain containing H1. (1364 aa)
	MSN	FERM domain-containing protein. (577 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOCUP00000034544	EPB41L1	ENSOCUP00000034544	ENSOCUP00000047298	FERM domain-containing protein.	Erythrocyte membrane protein band 4.1 like 1.	0.447
ENSOCUP00000034544	EZR	ENSOCUP00000034544	ENSOCUP00000040029	FERM domain-containing protein.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.794
ENSOCUP00000034544	MYO7A	ENSOCUP00000034544	ENSOCUP00000018448	FERM domain-containing protein.	Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.446
ENSOCUP00000034544	RDX	ENSOCUP00000034544	ENSOCUP00000037499	FERM domain-containing protein.	Radixin.	0.715
EPB41	EPB41L1	ENSOCUP00000005740	ENSOCUP00000047298	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 1.	0.453
EPB41	EPB41L2	ENSOCUP00000005740	ENSOCUP00000044119	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 2.	0.412
EPB41	EPB41L3	ENSOCUP00000005740	ENSOCUP00000042691	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 3.	0.493
EPB41	EPB41L5	ENSOCUP00000005740	ENSOCUP00000007247	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 5.	0.505
EPB41	EZR	ENSOCUP00000005740	ENSOCUP00000040029	Erythrocyte membrane protein band 4.1.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.596
EPB41	RDX	ENSOCUP00000005740	ENSOCUP00000037499	Erythrocyte membrane protein band 4.1.	Radixin.	0.566
EPB41L1	ENSOCUP00000034544	ENSOCUP00000047298	ENSOCUP00000034544	Erythrocyte membrane protein band 4.1 like 1.	FERM domain-containing protein.	0.447
EPB41L1	EPB41	ENSOCUP00000047298	ENSOCUP00000005740	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1.	0.453
EPB41L1	EPB41L2	ENSOCUP00000047298	ENSOCUP00000044119	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1 like 2.	0.597
EPB41L1	EPB41L3	ENSOCUP00000047298	ENSOCUP00000042691	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1 like 3.	0.558
EPB41L1	EPB41L5	ENSOCUP00000047298	ENSOCUP00000007247	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1 like 5.	0.408
EPB41L1	EZR	ENSOCUP00000047298	ENSOCUP00000040029	Erythrocyte membrane protein band 4.1 like 1.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.558
EPB41L1	MSN	ENSOCUP00000047298	ENSOCUP00000000131	Erythrocyte membrane protein band 4.1 like 1.	FERM domain-containing protein.	0.448
EPB41L1	MYO7A	ENSOCUP00000047298	ENSOCUP00000018448	Erythrocyte membrane protein band 4.1 like 1.	Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.509
EPB41L1	MYO7B	ENSOCUP00000047298	ENSOCUP00000018708	Erythrocyte membrane protein band 4.1 like 1.	Myosin VIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.419
EPB41L1	RDX	ENSOCUP00000047298	ENSOCUP00000037499	Erythrocyte membrane protein band 4.1 like 1.	Radixin.	0.537