(25 nodes) Death domain network (Oryctolagus cuniculus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	UNC5A	Unc-5 netrin receptor A. (819 aa)
	DTHD1	Death domain containing 1. (906 aa)
	IRAK2	Interleukin 1 receptor associated kinase 2. (592 aa)
	ANKDD1B	Ankyrin repeat and death domain containing 1B. (467 aa)
	ANK3	Ankyrin 3. (4364 aa)
	UNC5B	Unc-5 netrin receptor B. (946 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	UNC5CL	Unc-5 family C-terminal like. (518 aa)
	THOC1	THO complex 1. (657 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (670 aa)
	IRAK3	Interleukin 1 receptor associated kinase 3. (593 aa)
	G1TFT8_RABIT	Death domain-containing protein. (222 aa)
	TNFRSF25	TNF receptor superfamily member 25. (416 aa)
	TRADD	TNFRSF1A associated via death domain. (447 aa)
	NFKB1	Nuclear factor kappa B subunit 1. (968 aa)
	UNC5C	Unc-5 netrin receptor C. (931 aa)
	UNC5D	Unc-5 netrin receptor D. (958 aa)
	FAS	Uncharacterized protein. (484 aa)
	MYD88	Uncharacterized protein. (476 aa)
	ANK2	Ankyrin 2. (3805 aa)
	TNFRSF21	TNF receptor superfamily member 21. (655 aa)
	ANKDD1A	Ankyrin repeat and death domain containing 1A. (509 aa)
	EDARADD	EDAR associated death domain. (243 aa)
	TNFRSF1A	TNF receptor superfamily member 1A. (472 aa)
	DAPK1	Death associated protein kinase 1. (1493 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANK2	ANK3	ENSOCUP00000035379	ENSOCUP00000003069	Ankyrin 2.	Ankyrin 3.	0.912
ANK3	ANK2	ENSOCUP00000003069	ENSOCUP00000035379	Ankyrin 3.	Ankyrin 2.	0.912
DAPK1	UNC5B	ENSOCUP00000047216	ENSOCUP00000006006	Death associated protein kinase 1.	Unc-5 netrin receptor B.	0.581
FAS	RIPK1	ENSOCUP00000033980	ENSOCUP00000010138	Uncharacterized protein.	Receptor interacting serine/threonine kinase 1.	0.831
FAS	TNFRSF1A	ENSOCUP00000033980	ENSOCUP00000045661	Uncharacterized protein.	TNF receptor superfamily member 1A.	0.973
FAS	TNFRSF25	ENSOCUP00000033980	ENSOCUP00000017536	Uncharacterized protein.	TNF receptor superfamily member 25.	0.439
FAS	TRADD	ENSOCUP00000033980	ENSOCUP00000018718	Uncharacterized protein.	TNFRSF1A associated via death domain.	0.982
IRAK2	IRAK3	ENSOCUP00000002445	ENSOCUP00000012468	Interleukin 1 receptor associated kinase 2.	Interleukin 1 receptor associated kinase 3.	0.920
IRAK2	MYD88	ENSOCUP00000002445	ENSOCUP00000034296	Interleukin 1 receptor associated kinase 2.	Uncharacterized protein.	0.998
IRAK2	NFKB1	ENSOCUP00000002445	ENSOCUP00000023734	Interleukin 1 receptor associated kinase 2.	Nuclear factor kappa B subunit 1.	0.518
IRAK2	RIPK1	ENSOCUP00000002445	ENSOCUP00000010138	Interleukin 1 receptor associated kinase 2.	Receptor interacting serine/threonine kinase 1.	0.482
IRAK2	TNFRSF1A	ENSOCUP00000002445	ENSOCUP00000045661	Interleukin 1 receptor associated kinase 2.	TNF receptor superfamily member 1A.	0.454
IRAK2	TRADD	ENSOCUP00000002445	ENSOCUP00000018718	Interleukin 1 receptor associated kinase 2.	TNFRSF1A associated via death domain.	0.443
IRAK3	IRAK2	ENSOCUP00000012468	ENSOCUP00000002445	Interleukin 1 receptor associated kinase 3.	Interleukin 1 receptor associated kinase 2.	0.920
IRAK3	MYD88	ENSOCUP00000012468	ENSOCUP00000034296	Interleukin 1 receptor associated kinase 3.	Uncharacterized protein.	0.854
IRAK3	NFKB1	ENSOCUP00000012468	ENSOCUP00000023734	Interleukin 1 receptor associated kinase 3.	Nuclear factor kappa B subunit 1.	0.400
MYD88	IRAK2	ENSOCUP00000034296	ENSOCUP00000002445	Uncharacterized protein.	Interleukin 1 receptor associated kinase 2.	0.998
MYD88	IRAK3	ENSOCUP00000034296	ENSOCUP00000012468	Uncharacterized protein.	Interleukin 1 receptor associated kinase 3.	0.854
MYD88	NFKB1	ENSOCUP00000034296	ENSOCUP00000023734	Uncharacterized protein.	Nuclear factor kappa B subunit 1.	0.802
MYD88	RIPK1	ENSOCUP00000034296	ENSOCUP00000010138	Uncharacterized protein.	Receptor interacting serine/threonine kinase 1.	0.745