(20 nodes) Tissue inhibitor of metalloproteinases-like, OB-fold network (Oryctolagus cuniculus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	LOC103348521	NTR domain-containing protein. (225 aa)
	PCOLCE	Procollagen C-endopeptidase enhancer. (437 aa)
	NTN4	Netrin 4. (697 aa)
	NTN5	Netrin 5. (580 aa)
	SFRP1	NTR domain-containing protein. (209 aa)
	SFRP5	Secreted frizzled related protein 5. (314 aa)
	WFIKKN2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (571 aa)
	C5	Complement C5. (1678 aa)
	TIMP2	Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (1218 aa)
	NTN3	Netrin 3. (393 aa)
	C4A	Uncharacterized protein. (1743 aa)
	C3	Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. (726 aa)
	TIMP3	Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity). (211 aa)
	LOC100346672	Uncharacterized protein. (1673 aa)
	FRZB	Frizzled related protein. (318 aa)
	TIMP1	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (256 aa)
	PCOLCE2	Procollagen C-endopeptidase enhancer 2. (417 aa)
	SFRP4	Secreted frizzled related protein 4. (346 aa)
	TIMP4	Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. (224 aa)
	SFRP2	Secreted frizzled related protein 2. (295 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C3	C5	ENSOCUP00000006634	ENSOCUP00000004927	Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.	Complement C5.	0.579
C4A	C5	ENSOCUP00000006093	ENSOCUP00000004927	Uncharacterized protein.	Complement C5.	0.533
C5	C3	ENSOCUP00000004927	ENSOCUP00000006634	Complement C5.	Complement C3 alpha chain; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.	0.579
C5	C4A	ENSOCUP00000004927	ENSOCUP00000006093	Complement C5.	Uncharacterized protein.	0.533
C5	LOC100346672	ENSOCUP00000004927	ENSOCUP00000008700	Complement C5.	Uncharacterized protein.	0.579
FRZB	SFRP1	ENSOCUP00000008935	ENSOCUP00000017413	Frizzled related protein.	NTR domain-containing protein.	0.750
FRZB	SFRP2	ENSOCUP00000008935	ENSOCUP00000014323	Frizzled related protein.	Secreted frizzled related protein 2.	0.421
LOC100346672	C5	ENSOCUP00000008700	ENSOCUP00000004927	Uncharacterized protein.	Complement C5.	0.579
SFRP1	FRZB	ENSOCUP00000017413	ENSOCUP00000008935	NTR domain-containing protein.	Frizzled related protein.	0.750
SFRP1	SFRP4	ENSOCUP00000017413	ENSOCUP00000013636	NTR domain-containing protein.	Secreted frizzled related protein 4.	0.815
SFRP2	FRZB	ENSOCUP00000014323	ENSOCUP00000008935	Secreted frizzled related protein 2.	Frizzled related protein.	0.421
SFRP2	SFRP4	ENSOCUP00000014323	ENSOCUP00000013636	Secreted frizzled related protein 2.	Secreted frizzled related protein 4.	0.492
SFRP4	SFRP1	ENSOCUP00000013636	ENSOCUP00000017413	Secreted frizzled related protein 4.	NTR domain-containing protein.	0.815
SFRP4	SFRP2	ENSOCUP00000013636	ENSOCUP00000014323	Secreted frizzled related protein 4.	Secreted frizzled related protein 2.	0.492
TIMP1	TIMP3	ENSOCUP00000009228	ENSOCUP00000007183	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity).	0.426
TIMP3	TIMP1	ENSOCUP00000007183	ENSOCUP00000009228	Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity).	Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).	0.426
TIMP3	TIMP4	ENSOCUP00000007183	ENSOCUP00000013706	Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity).	Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	0.477
TIMP4	TIMP3	ENSOCUP00000013706	ENSOCUP00000007183	Metalloproteinase inhibitor 4; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family.	Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli (By similarity).	0.477