STRINGSTRING
IFNG IFNG GH1 GH1 LOC100353137 LOC100353137 CNTF CNTF EPO EPO CTF1 CTF1 THPO THPO IL23A IL23A IL15 IL15 CSF3 CSF3 IL2 IL2 LEP LEP OSM OSM LOC100358223 LOC100358223 IL19 IL19 IL20 IL20 IL21 IL21 G1T9X6_RABIT G1T9X6_RABIT LOC100355669 LOC100355669 IL6 IL6 LOC100354654 LOC100354654 LOC100357194 LOC100357194 IL10 IL10 IFNB1 IFNB1 IL-15L IL-15L IFNK IFNK G1U0P1_RABIT G1U0P1_RABIT G1U5P7_RABIT G1U5P7_RABIT IL4 IL4 CSF1 CSF1 IFNE IFNE KITLG KITLG ENSOCUP00000033859 ENSOCUP00000033859 CLCF1 CLCF1 IL12A IL12A LOC100357452 LOC100357452 LOC100354910 LOC100354910 LOC100356937 LOC100356937 LIF LIF IL5 IL5 CSF2 CSF2 LOC100353390-2 LOC100353390-2 LOC100355421 LOC100355421 LOC100354397 LOC100354397 LOC100353390 LOC100353390 IL22 IL22 PRL PRL IL26 IL26 IL13 IL13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa)
LOC100353137Uncharacterized protein. (195 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (199 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa)
CTF1Cardiotrophin 1. (190 aa)
THPOThrombopoietin. (348 aa)
IL23AInterleukin 23 subunit alpha. (191 aa)
IL15Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa)
CSF3Colony stimulating factor 3. (204 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
OSMUncharacterized protein. (333 aa)
LOC100358223Uncharacterized protein. (195 aa)
IL19Interleukin 19. (233 aa)
IL20Interleukin 20. (187 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (154 aa)
G1T9X6_RABITUncharacterized protein. (188 aa)
LOC100355669Uncharacterized protein. (190 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa)
LOC100354654Uncharacterized protein. (189 aa)
LOC100357194Uncharacterized protein. (189 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa)
IFNB1Interferon beta 1. (180 aa)
IL-15LInterleukin 15-like protein. (136 aa)
IFNKInterferon kappa. (198 aa)
G1U0P1_RABITUncharacterized protein. (209 aa)
G1U5P7_RABITUncharacterized protein. (204 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa)
CSF1Colony stimulating factor 1. (535 aa)
IFNEInterferon epsilon. (212 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa)
ENSOCUP00000033859Uncharacterized protein. (176 aa)
CLCF1Cardiotrophin like cytokine factor 1. (301 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa)
LOC100357452Uncharacterized protein. (190 aa)
LOC100354910Uncharacterized protein. (187 aa)
LOC100356937Uncharacterized protein. (195 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
CSF2Uncharacterized protein. (144 aa)
LOC100353390-2Uncharacterized protein. (190 aa)
LOC100355421Uncharacterized protein. (195 aa)
LOC100354397Uncharacterized protein. (195 aa)
LOC100353390Uncharacterized protein. (189 aa)
IL22Interleukin 22. (187 aa)
PRLProlactin; Prolactin acts primarily on the mammary gland by promoting lactation. (262 aa)
IL26Interleukin 26. (180 aa)
IL13Interleukin 13. (138 aa)
Your Current Organism:
Oryctolagus cuniculus
NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits
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