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IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (198 aa) | ||||
GH1 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa) | ||||
LOC100353137 | Uncharacterized protein. (195 aa) | ||||
CNTF | Ciliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (199 aa) | ||||
EPO | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (195 aa) | ||||
CTF1 | Cardiotrophin 1. (190 aa) | ||||
THPO | Thrombopoietin. (348 aa) | ||||
IL23A | Interleukin 23 subunit alpha. (191 aa) | ||||
IL15 | Interleukin-15; Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA (By similarity). In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, which results in kinase SYK activation (By similarity). (162 aa) | ||||
CSF3 | Colony stimulating factor 3. (204 aa) | ||||
IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (153 aa) | ||||
LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa) | ||||
OSM | Uncharacterized protein. (333 aa) | ||||
LOC100358223 | Uncharacterized protein. (195 aa) | ||||
IL19 | Interleukin 19. (233 aa) | ||||
IL20 | Interleukin 20. (187 aa) | ||||
IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (154 aa) | ||||
G1T9X6_RABIT | Uncharacterized protein. (188 aa) | ||||
LOC100355669 | Uncharacterized protein. (190 aa) | ||||
IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (241 aa) | ||||
LOC100354654 | Uncharacterized protein. (189 aa) | ||||
LOC100357194 | Uncharacterized protein. (189 aa) | ||||
IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (304 aa) | ||||
IFNB1 | Interferon beta 1. (180 aa) | ||||
IL-15L | Interleukin 15-like protein. (136 aa) | ||||
IFNK | Interferon kappa. (198 aa) | ||||
G1U0P1_RABIT | Uncharacterized protein. (209 aa) | ||||
G1U5P7_RABIT | Uncharacterized protein. (204 aa) | ||||
IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (144 aa) | ||||
CSF1 | Colony stimulating factor 1. (535 aa) | ||||
IFNE | Interferon epsilon. (212 aa) | ||||
KITLG | Kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (276 aa) | ||||
ENSOCUP00000033859 | Uncharacterized protein. (176 aa) | ||||
CLCF1 | Cardiotrophin like cytokine factor 1. (301 aa) | ||||
IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (233 aa) | ||||
LOC100357452 | Uncharacterized protein. (190 aa) | ||||
LOC100354910 | Uncharacterized protein. (187 aa) | ||||
LOC100356937 | Uncharacterized protein. (195 aa) | ||||
LIF | LIF interleukin 6 family cytokine. (203 aa) | ||||
IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa) | ||||
CSF2 | Uncharacterized protein. (144 aa) | ||||
LOC100353390-2 | Uncharacterized protein. (190 aa) | ||||
LOC100355421 | Uncharacterized protein. (195 aa) | ||||
LOC100354397 | Uncharacterized protein. (195 aa) | ||||
LOC100353390 | Uncharacterized protein. (189 aa) | ||||
IL22 | Interleukin 22. (187 aa) | ||||
PRL | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation. (262 aa) | ||||
IL26 | Interleukin 26. (180 aa) | ||||
IL13 | Interleukin 13. (138 aa) |