(24 nodes) FERM conserved site network (Oryctolagus cuniculus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTPN21	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1178 aa)
	MSN	FERM domain-containing protein. (577 aa)
	FRMD5	FERM domain containing 5. (570 aa)
	FRMD4B	FERM domain containing 4B. (1063 aa)
	NF2	Neurofibromin 2. (626 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (860 aa)
	PTPN4	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (926 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (731 aa)
	TLN1	Talin 1. (2558 aa)
	TLN2	Talin 2. (2536 aa)
	PTPN14	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. (1180 aa)
	EPB41L4B	Erythrocyte membrane protein band 4.1 like 4B. (811 aa)
	FRMD7	FERM domain containing 7. (710 aa)
	FARP1	FERM, ARH/RhoGEF and pleckstrin domain protein 1. (1129 aa)
	FRMD3	FERM domain containing 3. (583 aa)
	ENSOCUP00000034544	FERM domain-containing protein. (508 aa)
	RDX	Radixin. (643 aa)
	FRMD4A	FERM domain containing 4A. (1064 aa)
	EZR	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). (653 aa)
	EPB41L4A	Erythrocyte membrane protein band 4.1 like 4A. (691 aa)
	EPB41L3	Erythrocyte membrane protein band 4.1 like 3. (1447 aa)
	PTPN3	Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (1005 aa)
	EPB41L2	Erythrocyte membrane protein band 4.1 like 2. (1105 aa)
	EPB41L1	Erythrocyte membrane protein band 4.1 like 1. (947 aa)

Your Current Organism:

Oryctolagus cuniculus

NCBI taxonomy Id: 9986
Other names: European rabbit, Japanese white rabbit, Lepus cuniculus, New Zealand rabbit, O. cuniculus, domestic rabbit, rabbit, rabbits

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSOCUP00000034544	EPB41L1	ENSOCUP00000034544	ENSOCUP00000047298	FERM domain-containing protein.	Erythrocyte membrane protein band 4.1 like 1.	0.447
ENSOCUP00000034544	EZR	ENSOCUP00000034544	ENSOCUP00000040029	FERM domain-containing protein.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.794
ENSOCUP00000034544	RDX	ENSOCUP00000034544	ENSOCUP00000037499	FERM domain-containing protein.	Radixin.	0.715
EPB41	EPB41L1	ENSOCUP00000005740	ENSOCUP00000047298	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 1.	0.453
EPB41	EPB41L2	ENSOCUP00000005740	ENSOCUP00000044119	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 2.	0.412
EPB41	EPB41L3	ENSOCUP00000005740	ENSOCUP00000042691	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 3.	0.493
EPB41	EPB41L5	ENSOCUP00000005740	ENSOCUP00000007247	Erythrocyte membrane protein band 4.1.	Erythrocyte membrane protein band 4.1 like 5.	0.505
EPB41	EZR	ENSOCUP00000005740	ENSOCUP00000040029	Erythrocyte membrane protein band 4.1.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.596
EPB41	RDX	ENSOCUP00000005740	ENSOCUP00000037499	Erythrocyte membrane protein band 4.1.	Radixin.	0.566
EPB41L1	ENSOCUP00000034544	ENSOCUP00000047298	ENSOCUP00000034544	Erythrocyte membrane protein band 4.1 like 1.	FERM domain-containing protein.	0.447
EPB41L1	EPB41	ENSOCUP00000047298	ENSOCUP00000005740	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1.	0.453
EPB41L1	EPB41L2	ENSOCUP00000047298	ENSOCUP00000044119	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1 like 2.	0.597
EPB41L1	EPB41L3	ENSOCUP00000047298	ENSOCUP00000042691	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1 like 3.	0.558
EPB41L1	EPB41L5	ENSOCUP00000047298	ENSOCUP00000007247	Erythrocyte membrane protein band 4.1 like 1.	Erythrocyte membrane protein band 4.1 like 5.	0.408
EPB41L1	EZR	ENSOCUP00000047298	ENSOCUP00000040029	Erythrocyte membrane protein band 4.1 like 1.	Ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane (By similarity). In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity).	0.558
EPB41L1	MSN	ENSOCUP00000047298	ENSOCUP00000000131	Erythrocyte membrane protein band 4.1 like 1.	FERM domain-containing protein.	0.448
EPB41L1	RDX	ENSOCUP00000047298	ENSOCUP00000037499	Erythrocyte membrane protein band 4.1 like 1.	Radixin.	0.537
EPB41L2	EPB41	ENSOCUP00000044119	ENSOCUP00000005740	Erythrocyte membrane protein band 4.1 like 2.	Erythrocyte membrane protein band 4.1.	0.412
EPB41L2	EPB41L1	ENSOCUP00000044119	ENSOCUP00000047298	Erythrocyte membrane protein band 4.1 like 2.	Erythrocyte membrane protein band 4.1 like 1.	0.597
EPB41L2	EPB41L3	ENSOCUP00000044119	ENSOCUP00000042691	Erythrocyte membrane protein band 4.1 like 2.	Erythrocyte membrane protein band 4.1 like 3.	0.639